Solubility and thermodynamic analysis of amlodipine besylate in mixtures of propylene glycol and 1-propanol from 293.2 to 323.2 K
The solubility characteristics of amlodipine besylate (ADB) in various propylene glycol and 1-propanol mixtures were quantitatively determined using a spectrophotometric approach, post equilibration via the established shake-flask technique. This solubility quantification was extended across a spect...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Chemical Thermodynamics and Thermal Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667312625000112 |
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| Summary: | The solubility characteristics of amlodipine besylate (ADB) in various propylene glycol and 1-propanol mixtures were quantitatively determined using a spectrophotometric approach, post equilibration via the established shake-flask technique. This solubility quantification was extended across a spectrum of five distinct temperatures, ranging from 293.2 K to 313.2 K, in conjunction with eleven discrete mass fractions. It was observed that the solubility of ADB exhibited an enhancement concomitant with an increase in the propylene glycol mass fraction, culminating in a maximal solubility value at 313.2 K for a propylene glycol mass fraction of 0.8. The solubility data of ADB was subjected to correlation analysis using a variety of linear cosolvency models, yielding mean percentage deviations spanning from 1.0 % to 24.8 %. In the realm of thermodynamics, the apparent parameters, namely enthalpy, entropy, and Gibbs free energy, pertinent to the dissolution processes of ADB were computed. The derived enthalpy-entropy relationship for ADB demonstrated a non-linear behavior. Specifically, the plot of enthalpy against Gibbs energy revealed positive slopes in the ranges of w1=0.0 to w1=0.1, w1=0.2 to w1=0.3, w1=0.4 to w1=0.5, w1=0.6 to w1=0.7, and w1=0.8 to w1=1.0 in these mixtures, but transitioning to negative slopes between w1=0.1 and w1=0.2, w1=0.3 to w1=0.4, w1=0.5 to w1=0.6, and w1=0.7 to w1=0.8. |
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| ISSN: | 2667-3126 |