MitoSeg: Mitochondria segmentation tool
Recent studies suggest a potential link between the physical structure of mitochondria and neurodegenerative diseases. With advances in Electron Microscopy techniques, it has become possible to visualize the boundary and cristae structures of mitochondria in detail. Segmenting mitochondria from micr...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | SoftwareX |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352711025000482 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859398326353920 |
|---|---|
| author | Faris Serdar Taşel Efe Çi̇ftci̇ |
| author_facet | Faris Serdar Taşel Efe Çi̇ftci̇ |
| author_sort | Faris Serdar Taşel |
| collection | DOAJ |
| description | Recent studies suggest a potential link between the physical structure of mitochondria and neurodegenerative diseases. With advances in Electron Microscopy techniques, it has become possible to visualize the boundary and cristae structures of mitochondria in detail. Segmenting mitochondria from microscopy images remains challenging due to image quality and complex morphology of mitochondria, including cristae and the other subcellular structures. It is crucial to automatically segment mitochondria from images exhibiting different mitochondrial boundary and crista characteristics to investigate the relationship between mitochondria and diseases. In this paper, we present a software solution for mitochondrial segmentation using an automatic validation scheme based on the general physical properties of mitochondria, highlighting boundaries in electron microscopy tomography images and generating corresponding 3D meshes. These capabilities help researchers conduct further investigations into mitochondrial morphology and explore its role in the mechanisms of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-607e433915eb4a968b7c3bd36b1d9cbb |
| institution | Kabale University |
| issn | 2352-7110 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SoftwareX |
| spelling | doaj-art-607e433915eb4a968b7c3bd36b1d9cbb2025-02-11T04:35:07ZengElsevierSoftwareX2352-71102025-05-0130102081MitoSeg: Mitochondria segmentation toolFaris Serdar Taşel0Efe Çi̇ftci̇1Department of Computer Engineering, Çankaya University, Ankara, Turkey; Corresponding author.Computer Programming Program, Çankaya University, Ankara, TurkeyRecent studies suggest a potential link between the physical structure of mitochondria and neurodegenerative diseases. With advances in Electron Microscopy techniques, it has become possible to visualize the boundary and cristae structures of mitochondria in detail. Segmenting mitochondria from microscopy images remains challenging due to image quality and complex morphology of mitochondria, including cristae and the other subcellular structures. It is crucial to automatically segment mitochondria from images exhibiting different mitochondrial boundary and crista characteristics to investigate the relationship between mitochondria and diseases. In this paper, we present a software solution for mitochondrial segmentation using an automatic validation scheme based on the general physical properties of mitochondria, highlighting boundaries in electron microscopy tomography images and generating corresponding 3D meshes. These capabilities help researchers conduct further investigations into mitochondrial morphology and explore its role in the mechanisms of neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S2352711025000482Electron tomographyMitochondrionSegmentation |
| spellingShingle | Faris Serdar Taşel Efe Çi̇ftci̇ MitoSeg: Mitochondria segmentation tool SoftwareX Electron tomography Mitochondrion Segmentation |
| title | MitoSeg: Mitochondria segmentation tool |
| title_full | MitoSeg: Mitochondria segmentation tool |
| title_fullStr | MitoSeg: Mitochondria segmentation tool |
| title_full_unstemmed | MitoSeg: Mitochondria segmentation tool |
| title_short | MitoSeg: Mitochondria segmentation tool |
| title_sort | mitoseg mitochondria segmentation tool |
| topic | Electron tomography Mitochondrion Segmentation |
| url | http://www.sciencedirect.com/science/article/pii/S2352711025000482 |
| work_keys_str_mv | AT farisserdartasel mitosegmitochondriasegmentationtool AT efeciftci mitosegmitochondriasegmentationtool |