Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites
Taxifolin (TAX), as a natural flavonoid, has been widely focused on due to its strong anti-oxidation, anti-inflammation, anti-virus, and even anti-tumor activity. However, the effect of TAX on semen quality was unknown. The purpose of this study was to analyze the beneficial influences of adding fee...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1020628/full |
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| author | Yexun Zhou Yexun Zhou Liang Chen Hui Han Hui Han Bohui Xiong Ruqing Zhong Yue Jiang Lei Liu Haiqing Sun Jiajian Tan Xiaowei Cheng Martine Schroyen Yang Gao Yong Zhao Hongfu Zhang |
| author_facet | Yexun Zhou Yexun Zhou Liang Chen Hui Han Hui Han Bohui Xiong Ruqing Zhong Yue Jiang Lei Liu Haiqing Sun Jiajian Tan Xiaowei Cheng Martine Schroyen Yang Gao Yong Zhao Hongfu Zhang |
| author_sort | Yexun Zhou |
| collection | DOAJ |
| description | Taxifolin (TAX), as a natural flavonoid, has been widely focused on due to its strong anti-oxidation, anti-inflammation, anti-virus, and even anti-tumor activity. However, the effect of TAX on semen quality was unknown. The purpose of this study was to analyze the beneficial influences of adding feed additive TAX to boar semen in terms of its quality and potential mechanisms. We discovered that TAX increased sperm motility significantly in Duroc boars by the elevation of the protein levels such as ZAG, PKA, CatSper, and p-ERK for sperm quality. TAX increased the blood concentration of testosterone derivatives, antioxidants such as melatonin and betaine, unsaturated fatty acids such as DHA, and beneficial amino acids such as proline. Conversely, TAX decreased 10 different kinds of bile acids in the plasma. Moreover, TAX increased “beneficial” microbes such as Intestinimonas, Coprococcus, Butyrivibrio, and Clostridium_XlVa at the Genus level. However, TAX reduced the “harmful” intestinal bacteria such as Prevotella, Howardella, Mogibacterium, and Enterococcus. There was a very close correlation between fecal microbes, plasma metabolites, and semen parameters by the spearman correlation analysis. Therefore, the data suggest that TAX increases the semen quality of Duroc boars by benefiting the gut microbes and blood metabolites. It is supposed that TAX could be used as a kind of feed additive to increase the semen quality of boars to enhance production performance. |
| format | Article |
| id | doaj-art-6085b92972694b27ab42da7d9989f059 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-6085b92972694b27ab42da7d9989f0592025-02-07T10:05:26ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-10-011310.3389/fmicb.2022.10206281020628Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolitesYexun Zhou0Yexun Zhou1Liang Chen2Hui Han3Hui Han4Bohui Xiong5Ruqing Zhong6Yue Jiang7Lei Liu8Haiqing Sun9Jiajian Tan10Xiaowei Cheng11Martine Schroyen12Yang Gao13Yong Zhao14Hongfu Zhang15State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaPrecision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux, BelgiumState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaPrecision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux, BelgiumState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaYangXiang Joint Stock Company, Guigang, ChinaYangXiang Joint Stock Company, Guigang, ChinaYinuo Biopharmaceutical Co., Ltd, Harbin, ChinaPrecision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux, BelgiumCollege of Life Science, Baicheng Normal University, Baicheng, Jilin, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaTaxifolin (TAX), as a natural flavonoid, has been widely focused on due to its strong anti-oxidation, anti-inflammation, anti-virus, and even anti-tumor activity. However, the effect of TAX on semen quality was unknown. The purpose of this study was to analyze the beneficial influences of adding feed additive TAX to boar semen in terms of its quality and potential mechanisms. We discovered that TAX increased sperm motility significantly in Duroc boars by the elevation of the protein levels such as ZAG, PKA, CatSper, and p-ERK for sperm quality. TAX increased the blood concentration of testosterone derivatives, antioxidants such as melatonin and betaine, unsaturated fatty acids such as DHA, and beneficial amino acids such as proline. Conversely, TAX decreased 10 different kinds of bile acids in the plasma. Moreover, TAX increased “beneficial” microbes such as Intestinimonas, Coprococcus, Butyrivibrio, and Clostridium_XlVa at the Genus level. However, TAX reduced the “harmful” intestinal bacteria such as Prevotella, Howardella, Mogibacterium, and Enterococcus. There was a very close correlation between fecal microbes, plasma metabolites, and semen parameters by the spearman correlation analysis. Therefore, the data suggest that TAX increases the semen quality of Duroc boars by benefiting the gut microbes and blood metabolites. It is supposed that TAX could be used as a kind of feed additive to increase the semen quality of boars to enhance production performance.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1020628/fullTaxifolinsemen qualityblood metabolitegut microbiotaboar |
| spellingShingle | Yexun Zhou Yexun Zhou Liang Chen Hui Han Hui Han Bohui Xiong Ruqing Zhong Yue Jiang Lei Liu Haiqing Sun Jiajian Tan Xiaowei Cheng Martine Schroyen Yang Gao Yong Zhao Hongfu Zhang Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites Frontiers in Microbiology Taxifolin semen quality blood metabolite gut microbiota boar |
| title | Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites |
| title_full | Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites |
| title_fullStr | Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites |
| title_full_unstemmed | Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites |
| title_short | Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites |
| title_sort | taxifolin increased semen quality of duroc boars by improving gut microbes and blood metabolites |
| topic | Taxifolin semen quality blood metabolite gut microbiota boar |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1020628/full |
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