Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan
Abstract Previous studies have shown that aspirin is effective as a prophylactic agent against venous thromboembolism (VTE) following proximal femoral fractures (PFF). In Japan, there is a lack of evidence regarding its efficacy and safety in this context. Consequently, aspirin is not covered by ins...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88493-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862480920641536 |
|---|---|
| author | Takao Ohmori Kazukiyo Toda Takuya Taoka Takeshi Ishihara Yasuo Ito |
| author_facet | Takao Ohmori Kazukiyo Toda Takuya Taoka Takeshi Ishihara Yasuo Ito |
| author_sort | Takao Ohmori |
| collection | DOAJ |
| description | Abstract Previous studies have shown that aspirin is effective as a prophylactic agent against venous thromboembolism (VTE) following proximal femoral fractures (PFF). In Japan, there is a lack of evidence regarding its efficacy and safety in this context. Consequently, aspirin is not covered by insurance for the prevention of venous thrombosis. This study aimed to investigate whether continued aspirin use in patients with PFF, who were already taking aspirin for cerebrovascular disease prevention before injury is effective as a prophylaxis for deep vein thrombosis (DVT). We retrospectively analyzed PFF patients (≥ 65 years) who underwent postoperative duplex ultrasonography from January 2010 to December 2023.The study compared patients taking aspirin alone (aspirin group) and those not taking antiplatelet agents or anticoagulants (control group), matched by propensity scores. We enrolled 1064 patients while 161 (15%) were in the aspirin group. After matching, 128 patients were analyzed. DVT incidence was not statistically significant between the aspirin (54) and control groups (60) (OR: 0.81; 95%CI: 0.49- 1.36; p = 0.44). Proximal DVT incidence was also similar (OR: 2; 95%CI: 0.50–7.00; p = 0.33). Additionally, since use of other postoperative antithrombotic prophylaxis (78%) is thought to have a significant impact on the incidence of DVT, a subgroup analysis was conducted to evaluate the effect of aspirin in patients who did not receive postoperative antithrombotic prophylaxis. Similarly, there was no statistically significant difference in either DVT (OR: 1.38; 95% CI: 0.55–3.42; p = 0.49) or proximal DVT (OR: 2.00; 95% CI: 0.37–10.92; p = 0.42). This study demonstrates that aspirin is not effective for preventing VTE in patients with PFF in Japan. |
| format | Article |
| id | doaj-art-6148878f48df4780996fc103bd71b456 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6148878f48df4780996fc103bd71b4562025-02-09T12:31:31ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-88493-4Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in JapanTakao Ohmori0Kazukiyo Toda1Takuya Taoka2Takeshi Ishihara3Yasuo Ito4Department of Orthopaedic Surgery, Japanese Red Cross Kobe HospitalDepartment of Orthopaedic Surgery, Japanese Red Cross Kobe HospitalDepartment of Orthopaedic Surgery, Japanese Red Cross Kobe HospitalDepartment of Orthopaedic Surgery, Japanese Red Cross Kobe HospitalDepartment of Orthopaedic Surgery, Japanese Red Cross Kobe HospitalAbstract Previous studies have shown that aspirin is effective as a prophylactic agent against venous thromboembolism (VTE) following proximal femoral fractures (PFF). In Japan, there is a lack of evidence regarding its efficacy and safety in this context. Consequently, aspirin is not covered by insurance for the prevention of venous thrombosis. This study aimed to investigate whether continued aspirin use in patients with PFF, who were already taking aspirin for cerebrovascular disease prevention before injury is effective as a prophylaxis for deep vein thrombosis (DVT). We retrospectively analyzed PFF patients (≥ 65 years) who underwent postoperative duplex ultrasonography from January 2010 to December 2023.The study compared patients taking aspirin alone (aspirin group) and those not taking antiplatelet agents or anticoagulants (control group), matched by propensity scores. We enrolled 1064 patients while 161 (15%) were in the aspirin group. After matching, 128 patients were analyzed. DVT incidence was not statistically significant between the aspirin (54) and control groups (60) (OR: 0.81; 95%CI: 0.49- 1.36; p = 0.44). Proximal DVT incidence was also similar (OR: 2; 95%CI: 0.50–7.00; p = 0.33). Additionally, since use of other postoperative antithrombotic prophylaxis (78%) is thought to have a significant impact on the incidence of DVT, a subgroup analysis was conducted to evaluate the effect of aspirin in patients who did not receive postoperative antithrombotic prophylaxis. Similarly, there was no statistically significant difference in either DVT (OR: 1.38; 95% CI: 0.55–3.42; p = 0.49) or proximal DVT (OR: 2.00; 95% CI: 0.37–10.92; p = 0.42). This study demonstrates that aspirin is not effective for preventing VTE in patients with PFF in Japan.https://doi.org/10.1038/s41598-025-88493-4Proximal femoral fracturesDeep vein thrombosisAspirinProphylaxisSurgery |
| spellingShingle | Takao Ohmori Kazukiyo Toda Takuya Taoka Takeshi Ishihara Yasuo Ito Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan Scientific Reports Proximal femoral fractures Deep vein thrombosis Aspirin Prophylaxis Surgery |
| title | Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan |
| title_full | Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan |
| title_fullStr | Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan |
| title_full_unstemmed | Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan |
| title_short | Effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in Japan |
| title_sort | effectiveness of aspirin in preventing deep vein thrombosis following proximal femoral fracture surgery in japan |
| topic | Proximal femoral fractures Deep vein thrombosis Aspirin Prophylaxis Surgery |
| url | https://doi.org/10.1038/s41598-025-88493-4 |
| work_keys_str_mv | AT takaoohmori effectivenessofaspirininpreventingdeepveinthrombosisfollowingproximalfemoralfracturesurgeryinjapan AT kazukiyotoda effectivenessofaspirininpreventingdeepveinthrombosisfollowingproximalfemoralfracturesurgeryinjapan AT takuyataoka effectivenessofaspirininpreventingdeepveinthrombosisfollowingproximalfemoralfracturesurgeryinjapan AT takeshiishihara effectivenessofaspirininpreventingdeepveinthrombosisfollowingproximalfemoralfracturesurgeryinjapan AT yasuoito effectivenessofaspirininpreventingdeepveinthrombosisfollowingproximalfemoralfracturesurgeryinjapan |