Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus
Abstract Background and aim The Coronavirus Disease 2019 (COVID-19) pandemic has disproportionately affected individuals with Type 2 Diabetes Mellitus (T2DM), making them more susceptible to viral infections. Additionally, COVID-19 and the associated lockdown restrictions have influenced metabolic r...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-025-03529-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823863422833393664 |
|---|---|
| author | Motahare Shabestari Forouzan Salari Reyhaneh Azizi Akram Ghadiri-Anari Nasim Namiranian |
| author_facet | Motahare Shabestari Forouzan Salari Reyhaneh Azizi Akram Ghadiri-Anari Nasim Namiranian |
| author_sort | Motahare Shabestari |
| collection | DOAJ |
| description | Abstract Background and aim The Coronavirus Disease 2019 (COVID-19) pandemic has disproportionately affected individuals with Type 2 Diabetes Mellitus (T2DM), making them more susceptible to viral infections. Additionally, COVID-19 and the associated lockdown restrictions have influenced metabolic regulatory mechanisms in this population. This study aims to evaluate the impact of COVID-19 infection and lockdown measures on physiological parameters in individuals with T2DM. Methods This retrospective cohort study included 118 individuals with a prior diagnosis of T2DM. Medical records were reviewed for laboratory tests conducted within three months before the onset of the COVID-19 pandemic in Iran. Fifty-nine patients with confirmed COVID-19 infection during the first three months of the pandemic underwent follow-up laboratory tests six months post-diagnosis. An age- and gender-matched group of 59 noninfected individuals underwent follow-up tests six months after the pandemic’s onset. Clinical and laboratory parameters were analyzed and compared within each group. Results In the COVID-19 positive group, significant reductions were observed in triglycerides (TG) (P = 0.001), total cholesterol (TC) (P = 0.028), body mass index (BMI) (P = 0.034), atherogenic index of plasma (AIP) (P = 0.027), triglyceride-glucose (TyG) index (P = 0.001), and triglyceride-glucose-BMI (TyG-BMI) index (P < 0.001) during the six months following infection compared to pre-pandemic levels. Other variables remained unchanged. In the COVID-19 negative group, significant reductions were noted in TC (P = 0.001) and low-density lipoprotein cholesterol (LDL-C) (P = 0.01). Conclusion T2DM patients with mild to moderate COVID-19 infection exhibited improvements in TC, TG, BMI, and insulin-related indices. Lockdown restrictions were associated with decreased TC and LDL-C levels in T2DM patients without a history of COVID-19 infection. |
| format | Article |
| id | doaj-art-62a34d51ed444142b7094e2c533fe11a |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-62a34d51ed444142b7094e2c533fe11a2025-02-09T12:09:38ZengBMCBMC Pulmonary Medicine1471-24662025-02-012511710.1186/s12890-025-03529-9Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitusMotahare Shabestari0Forouzan Salari1Reyhaneh Azizi2Akram Ghadiri-Anari3Nasim Namiranian4Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical SciencesShahid Sadoughi University of Medical SciencesDiabetic Research Center, Shahid Sadoughi University of Medical SciencesDiabetic Research Center, Shahid Sadoughi University of Medical SciencesDiabetic Research Center, Shahid Sadoughi University of Medical SciencesAbstract Background and aim The Coronavirus Disease 2019 (COVID-19) pandemic has disproportionately affected individuals with Type 2 Diabetes Mellitus (T2DM), making them more susceptible to viral infections. Additionally, COVID-19 and the associated lockdown restrictions have influenced metabolic regulatory mechanisms in this population. This study aims to evaluate the impact of COVID-19 infection and lockdown measures on physiological parameters in individuals with T2DM. Methods This retrospective cohort study included 118 individuals with a prior diagnosis of T2DM. Medical records were reviewed for laboratory tests conducted within three months before the onset of the COVID-19 pandemic in Iran. Fifty-nine patients with confirmed COVID-19 infection during the first three months of the pandemic underwent follow-up laboratory tests six months post-diagnosis. An age- and gender-matched group of 59 noninfected individuals underwent follow-up tests six months after the pandemic’s onset. Clinical and laboratory parameters were analyzed and compared within each group. Results In the COVID-19 positive group, significant reductions were observed in triglycerides (TG) (P = 0.001), total cholesterol (TC) (P = 0.028), body mass index (BMI) (P = 0.034), atherogenic index of plasma (AIP) (P = 0.027), triglyceride-glucose (TyG) index (P = 0.001), and triglyceride-glucose-BMI (TyG-BMI) index (P < 0.001) during the six months following infection compared to pre-pandemic levels. Other variables remained unchanged. In the COVID-19 negative group, significant reductions were noted in TC (P = 0.001) and low-density lipoprotein cholesterol (LDL-C) (P = 0.01). Conclusion T2DM patients with mild to moderate COVID-19 infection exhibited improvements in TC, TG, BMI, and insulin-related indices. Lockdown restrictions were associated with decreased TC and LDL-C levels in T2DM patients without a history of COVID-19 infection.https://doi.org/10.1186/s12890-025-03529-9Type 2 diabetesCOVID-19Metabolic profileCohort study |
| spellingShingle | Motahare Shabestari Forouzan Salari Reyhaneh Azizi Akram Ghadiri-Anari Nasim Namiranian Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus BMC Pulmonary Medicine Type 2 diabetes COVID-19 Metabolic profile Cohort study |
| title | Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus |
| title_full | Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus |
| title_fullStr | Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus |
| title_short | Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus |
| title_sort | impact of covid 19 on metabolic parameters in patients with type 2 diabetes mellitus |
| topic | Type 2 diabetes COVID-19 Metabolic profile Cohort study |
| url | https://doi.org/10.1186/s12890-025-03529-9 |
| work_keys_str_mv | AT motahareshabestari impactofcovid19onmetabolicparametersinpatientswithtype2diabetesmellitus AT forouzansalari impactofcovid19onmetabolicparametersinpatientswithtype2diabetesmellitus AT reyhanehazizi impactofcovid19onmetabolicparametersinpatientswithtype2diabetesmellitus AT akramghadirianari impactofcovid19onmetabolicparametersinpatientswithtype2diabetesmellitus AT nasimnamiranian impactofcovid19onmetabolicparametersinpatientswithtype2diabetesmellitus |