Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis
Background and Aims: Pancreatic cysts (PCs) are increasingly detected through abdominal imaging, prompting exploration of alternatives such as endoscopic ultrasound–guided PC ablation due to the risks and costs associated with surgery. This study conducts a systematic review and meta-analysis of end...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Gastro Hep Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572324001912 |
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| author | Ahmed Al Qady Kapil Dev Nayar Fatima Elmustafa Mohamed Salih Joseph Emran Amir Beirat Sasmith Menakuru Dana Harris Dan J. Echols Baoan Ji John M. DeWitt Zhen Wang Fernando F. Stancampiano Yan Bi |
| author_facet | Ahmed Al Qady Kapil Dev Nayar Fatima Elmustafa Mohamed Salih Joseph Emran Amir Beirat Sasmith Menakuru Dana Harris Dan J. Echols Baoan Ji John M. DeWitt Zhen Wang Fernando F. Stancampiano Yan Bi |
| author_sort | Ahmed Al Qady |
| collection | DOAJ |
| description | Background and Aims: Pancreatic cysts (PCs) are increasingly detected through abdominal imaging, prompting exploration of alternatives such as endoscopic ultrasound–guided PC ablation due to the risks and costs associated with surgery. This study conducts a systematic review and meta-analysis of endoscopic ultrasound–guided PC ablation’s short-term efficacy and complications for PC management. Methods: A systematic review and meta-analysis were carried out on PubMed, Ovid, Cochrane, and TRIP electronic databases. The primary outcome was cyst resolution (partial and complete) and persistence on imaging 12 months after ablation. The secondary outcome was procedure-related adverse events. Results: Eight studies were eligible for analysis. Complete cyst resolution on imaging 12 months after endoscopic ultrasound ablation was 50% [95% CI 36‒63, I2 = 85.31%]. Partial cyst resolution was 27% [95% CI 15‒41, I2 = 87.07%], and cyst persistence was 17% [95% CI 11‒24, I2 = 62.11%]. The rate of complete resolution varied depending on the treatment agent (for ethanol 29% [95% CI 10‒53]; lauromacrogol 51% [95% Cl 36‒67]; ethanol and paclitaxel 63% [95% CI 48‒76]; paclitaxel and gemcitabine 67% [95% CI 45‒83]; and ethanol, paclitaxel, and gemcitabine 61% [95% CI 39‒80]). Postprocedure adverse events included abdominal pain in 4% [95% CI 0‒11], pancreatitis in 3% [95% CI 1‒5], and fever in 1% [95% CI 0‒3] of all patients. Conclusion: The treatment of pancreatic cysts with endoscopic ultrasound ablation results in acceptable levels of complete resolution, and low incidence of severe adverse events. The effectiveness of this treatment is further enhanced when chemoablative agents are employed. |
| format | Article |
| id | doaj-art-6314c5de91b246f6b1980d20d3f0e1ed |
| institution | Kabale University |
| issn | 2772-5723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj-art-6314c5de91b246f6b1980d20d3f0e1ed2025-02-06T05:13:04ZengElsevierGastro Hep Advances2772-57232025-01-0144100595Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-AnalysisAhmed Al Qady0Kapil Dev Nayar1Fatima Elmustafa2Mohamed Salih3Joseph Emran4Amir Beirat5Sasmith Menakuru6Dana Harris7Dan J. Echols8Baoan Ji9John M. DeWitt10Zhen Wang11Fernando F. Stancampiano12Yan Bi13Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida; Department of Medicine, Indiana University School of Medicine, Muncie, Indiana; Correspondence: Address correspondence to: Ahmed Al Qady, MD, Division of Gastroenterology, Hepatology and Nutrition, University of Florida, 1329 SW 16th ST STE 5251, Gainesville, Florida 32608.Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FloridaDepartment of Medicine, Ascension Macomb-Oakland Hospital, Warren, MichiganDepartment of Internal Medicine, Cairo University Faculty of Medicine, Cairo, EgyptDepartment of Medicine, Indiana University School of Medicine, Muncie, IndianaDepartment of Medicine, Indiana University School of Medicine, Muncie, IndianaDepartment of Medicine, Indiana University School of Medicine, Muncie, IndianaDepartment of Medicine, Mayo Clinic, Jacksonville, FloridaDepartment of Medicine, Mayo Clinic, Jacksonville, FloridaDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FloridaDepartment of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IndianaDepartment of Health Care Delivery Research, Mayo Clinic, Rochester, MinnesotaDepartment of Medicine, Mayo Clinic, Jacksonville, FloridaDivision of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FloridaBackground and Aims: Pancreatic cysts (PCs) are increasingly detected through abdominal imaging, prompting exploration of alternatives such as endoscopic ultrasound–guided PC ablation due to the risks and costs associated with surgery. This study conducts a systematic review and meta-analysis of endoscopic ultrasound–guided PC ablation’s short-term efficacy and complications for PC management. Methods: A systematic review and meta-analysis were carried out on PubMed, Ovid, Cochrane, and TRIP electronic databases. The primary outcome was cyst resolution (partial and complete) and persistence on imaging 12 months after ablation. The secondary outcome was procedure-related adverse events. Results: Eight studies were eligible for analysis. Complete cyst resolution on imaging 12 months after endoscopic ultrasound ablation was 50% [95% CI 36‒63, I2 = 85.31%]. Partial cyst resolution was 27% [95% CI 15‒41, I2 = 87.07%], and cyst persistence was 17% [95% CI 11‒24, I2 = 62.11%]. The rate of complete resolution varied depending on the treatment agent (for ethanol 29% [95% CI 10‒53]; lauromacrogol 51% [95% Cl 36‒67]; ethanol and paclitaxel 63% [95% CI 48‒76]; paclitaxel and gemcitabine 67% [95% CI 45‒83]; and ethanol, paclitaxel, and gemcitabine 61% [95% CI 39‒80]). Postprocedure adverse events included abdominal pain in 4% [95% CI 0‒11], pancreatitis in 3% [95% CI 1‒5], and fever in 1% [95% CI 0‒3] of all patients. Conclusion: The treatment of pancreatic cysts with endoscopic ultrasound ablation results in acceptable levels of complete resolution, and low incidence of severe adverse events. The effectiveness of this treatment is further enhanced when chemoablative agents are employed.http://www.sciencedirect.com/science/article/pii/S2772572324001912Pancreatic CystsEndoscopic UltrasoundCyst Ablation |
| spellingShingle | Ahmed Al Qady Kapil Dev Nayar Fatima Elmustafa Mohamed Salih Joseph Emran Amir Beirat Sasmith Menakuru Dana Harris Dan J. Echols Baoan Ji John M. DeWitt Zhen Wang Fernando F. Stancampiano Yan Bi Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis Gastro Hep Advances Pancreatic Cysts Endoscopic Ultrasound Cyst Ablation |
| title | Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis |
| title_full | Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis |
| title_fullStr | Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis |
| title_short | Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis |
| title_sort | short term outcomes of endoscopic ultrasound guided pancreatic cyst ablation a systematic review and meta analysis |
| topic | Pancreatic Cysts Endoscopic Ultrasound Cyst Ablation |
| url | http://www.sciencedirect.com/science/article/pii/S2772572324001912 |
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