Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI
Abstract The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves as an independent risk predictor for cardiovascular outcomes. The coronary angiography-derived index of microcirculatory resistance (AMR) is computed to evaluate coronary microcirculatio...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-89269-6 |
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| author | Guoyu Wang Cen Xu Jian Wang Zhimei Teng Xiang Sha Kai Xu Ruzhu Wang Li Zhu |
| author_facet | Guoyu Wang Cen Xu Jian Wang Zhimei Teng Xiang Sha Kai Xu Ruzhu Wang Li Zhu |
| author_sort | Guoyu Wang |
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| description | Abstract The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves as an independent risk predictor for cardiovascular outcomes. The coronary angiography-derived index of microcirculatory resistance (AMR) is computed to evaluate coronary microcirculation. However, the association between the TyG index and the AMR in patients with type 2 diabetes mellitus (T2DM) and ST-segment elevation myocardial infarction (STEMI) remains unclear. We consecutively recruited 168 patients with T2DM and STEMI who underwent primary percutaneous coronary intervention (pPCI) at Taizhou People’s Hospital from January 2022 to December 2023. Patients were classified into low AMR group (AMR < 2.5) and high AMR group (AMR ≥ 2.5). The TyG index was calculated using the formula: ln [plasma triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. The study enrolled 81 patients in the low AMR group and 87 in the high AMR group, with the TyG index being significantly higher in the high AMR group. Multivariable logistic regression analysis revealed a significant association between the TyG index and high AMR after adjusting for confounding variables (odds ratio: 2.449, 95% confidence interval: 1.421–4.220, and p = 0.001). The area under the curve for the TyG index predicting high AMR was 0.650 (95% confidence interval: 0.57–0.73, p < 0.001), with a cut-off value of 9.57. Our findings indicate that the TyG index is significantly associated with AMR in T2DM patients with STEMI undergoing pPCI, suggesting it may serve as a valuable predictor of high AMR in this population. |
| format | Article |
| id | doaj-art-6334ea69b8584d67b5207c3141207f05 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
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| series | Scientific Reports |
| spelling | doaj-art-6334ea69b8584d67b5207c3141207f052025-02-09T12:35:58ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-89269-6Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCIGuoyu Wang0Cen Xu1Jian Wang2Zhimei Teng3Xiang Sha4Kai Xu5Ruzhu Wang6Li Zhu7Department of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Reproductive Medicine, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Nosocomial Infection Management, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityAbstract The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves as an independent risk predictor for cardiovascular outcomes. The coronary angiography-derived index of microcirculatory resistance (AMR) is computed to evaluate coronary microcirculation. However, the association between the TyG index and the AMR in patients with type 2 diabetes mellitus (T2DM) and ST-segment elevation myocardial infarction (STEMI) remains unclear. We consecutively recruited 168 patients with T2DM and STEMI who underwent primary percutaneous coronary intervention (pPCI) at Taizhou People’s Hospital from January 2022 to December 2023. Patients were classified into low AMR group (AMR < 2.5) and high AMR group (AMR ≥ 2.5). The TyG index was calculated using the formula: ln [plasma triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. The study enrolled 81 patients in the low AMR group and 87 in the high AMR group, with the TyG index being significantly higher in the high AMR group. Multivariable logistic regression analysis revealed a significant association between the TyG index and high AMR after adjusting for confounding variables (odds ratio: 2.449, 95% confidence interval: 1.421–4.220, and p = 0.001). The area under the curve for the TyG index predicting high AMR was 0.650 (95% confidence interval: 0.57–0.73, p < 0.001), with a cut-off value of 9.57. Our findings indicate that the TyG index is significantly associated with AMR in T2DM patients with STEMI undergoing pPCI, suggesting it may serve as a valuable predictor of high AMR in this population.https://doi.org/10.1038/s41598-025-89269-6ST-segment elevation myocardial infarctionAngiography-based index of coronary microcirculatory resistanceTriglyceride-glucose index |
| spellingShingle | Guoyu Wang Cen Xu Jian Wang Zhimei Teng Xiang Sha Kai Xu Ruzhu Wang Li Zhu Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI Scientific Reports ST-segment elevation myocardial infarction Angiography-based index of coronary microcirculatory resistance Triglyceride-glucose index |
| title | Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI |
| title_full | Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI |
| title_fullStr | Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI |
| title_full_unstemmed | Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI |
| title_short | Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI |
| title_sort | triglyceride glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and stemi undergoing primary pci |
| topic | ST-segment elevation myocardial infarction Angiography-based index of coronary microcirculatory resistance Triglyceride-glucose index |
| url | https://doi.org/10.1038/s41598-025-89269-6 |
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