Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation

Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation

Purpose: Paclitaxel-induced cognitive impairment (PICI) is a frequent and severe adverse reaction of chemotherapy. Increased neuroinflammation related to neutrophil extracellular traps (NETs) may play a key role in PICI. Shaoyao Gancao Decoction (SGD) is a classic Chinese prescription with good neur...

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Bibliographic Details
Main Authors: Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Phytomedicine Plus
Subjects:
Paclitaxel
Cognitive impairment
Shaoyao Gancao Decoction
NETs
PTEN-PI3K-AKT pathway
Mendelian randomization
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031324001234
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