Pleiotropic effects of rabeprazole at acid-related diseases
Aim of investigation. To study association interleukin-1 (IL-1) gene (rs16944), interleukin-6 (IL-6) gene (rs1800795), interleukin-10 (IL-10) gene (rs1800896) polymorphisms with development of acute pancreatitis (AP) in the Russian population. Material and methods. Whole blood samples were received...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2018-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/154 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860285465690112 |
|---|---|
| author | A. V. Zaborovsky I. V. Mayev D. N. Andreyev L. A. Tararina |
| author_facet | A. V. Zaborovsky I. V. Mayev D. N. Andreyev L. A. Tararina |
| author_sort | A. V. Zaborovsky |
| collection | DOAJ |
| description | Aim of investigation. To study association interleukin-1 (IL-1) gene (rs16944), interleukin-6 (IL-6) gene (rs1800795), interleukin-10 (IL-10) gene (rs1800896) polymorphisms with development of acute pancreatitis (AP) in the Russian population. Material and methods. Whole blood samples were received from 297 AP patients and 238 healthy controls. Genotyping of IL-1 gene (rs16944) polymorphisms, IL-6 gene (rs1800795), IL-10 gene (rs1800896) was carried out by polymerase chain reaction with allele discrimination by TaqMan-probes. Results. The genetic polymorphism combination 511СТ×174GC of IL-1 and IL-6 genes was associated to high risk of AP development (OR=2.25, 95%-CI 1.45-3.49; p=0.0018). According to stratification analysis smoking patients with 511CT genotype had higher AP risk, then the patients with other genotypes (OR=2.22, 95%-CI 1.3-3.79; p=0.003). Paired combination of genotypes to disease risk analysis demonstrated that at 511СT×174GС genotype combination the AP risk is highest at alcohol abuse history for over 10 years (OR=2.88, 95%-CI 1.59-5.23; p=0.0004). Conclusion. Interleukin genetic polymorphism investigation may be useful at assessment of cytokine status in AP patients to predict the outcomes and to develop the personalized approach to treatment and prophylaxis. |
| format | Article |
| id | doaj-art-648fe8317123487d8523f323ee561683 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-648fe8317123487d8523f323ee5616832025-02-10T16:14:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01273182610.22416/1382-4376-2017-27-3-18-26154Pleiotropic effects of rabeprazole at acid-related diseasesA. V. Zaborovsky0I. V. Mayev1D. N. Andreyev2L. A. Tararina3State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry»State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry»State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry»State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry»Aim of investigation. To study association interleukin-1 (IL-1) gene (rs16944), interleukin-6 (IL-6) gene (rs1800795), interleukin-10 (IL-10) gene (rs1800896) polymorphisms with development of acute pancreatitis (AP) in the Russian population. Material and methods. Whole blood samples were received from 297 AP patients and 238 healthy controls. Genotyping of IL-1 gene (rs16944) polymorphisms, IL-6 gene (rs1800795), IL-10 gene (rs1800896) was carried out by polymerase chain reaction with allele discrimination by TaqMan-probes. Results. The genetic polymorphism combination 511СТ×174GC of IL-1 and IL-6 genes was associated to high risk of AP development (OR=2.25, 95%-CI 1.45-3.49; p=0.0018). According to stratification analysis smoking patients with 511CT genotype had higher AP risk, then the patients with other genotypes (OR=2.22, 95%-CI 1.3-3.79; p=0.003). Paired combination of genotypes to disease risk analysis demonstrated that at 511СT×174GС genotype combination the AP risk is highest at alcohol abuse history for over 10 years (OR=2.88, 95%-CI 1.59-5.23; p=0.0004). Conclusion. Interleukin genetic polymorphism investigation may be useful at assessment of cytokine status in AP patients to predict the outcomes and to develop the personalized approach to treatment and prophylaxis.https://www.gastro-j.ru/jour/article/view/154кислотозависимые заболеванияингибиторы протонной помпырабепразолгастроэзофагеальная рефлюксная болезньhelicobacter pyloriэрадикация |
| spellingShingle | A. V. Zaborovsky I. V. Mayev D. N. Andreyev L. A. Tararina Pleiotropic effects of rabeprazole at acid-related diseases Российский журнал гастроэнтерологии, гепатологии, колопроктологии кислотозависимые заболевания ингибиторы протонной помпы рабепразол гастроэзофагеальная рефлюксная болезнь helicobacter pylori эрадикация |
| title | Pleiotropic effects of rabeprazole at acid-related diseases |
| title_full | Pleiotropic effects of rabeprazole at acid-related diseases |
| title_fullStr | Pleiotropic effects of rabeprazole at acid-related diseases |
| title_full_unstemmed | Pleiotropic effects of rabeprazole at acid-related diseases |
| title_short | Pleiotropic effects of rabeprazole at acid-related diseases |
| title_sort | pleiotropic effects of rabeprazole at acid related diseases |
| topic | кислотозависимые заболевания ингибиторы протонной помпы рабепразол гастроэзофагеальная рефлюксная болезнь helicobacter pylori эрадикация |
| url | https://www.gastro-j.ru/jour/article/view/154 |
| work_keys_str_mv | AT avzaborovsky pleiotropiceffectsofrabeprazoleatacidrelateddiseases AT ivmayev pleiotropiceffectsofrabeprazoleatacidrelateddiseases AT dnandreyev pleiotropiceffectsofrabeprazoleatacidrelateddiseases AT latararina pleiotropiceffectsofrabeprazoleatacidrelateddiseases |