Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case
Acute megakaryoblastic leukemia (AML-M7) is rarely seen in adult patients and patients usually present with cytopenias. Here we discuss diagnostic challenges and pathologic features in a patient with AML-M7 who presented with thrombocytosis and diarrhea. A 63-year-old male patient presented with per...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_233_22 |
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| author | Nevin Alayvaz Aslan Gülsün Gülten |
| author_facet | Nevin Alayvaz Aslan Gülsün Gülten |
| author_sort | Nevin Alayvaz Aslan |
| collection | DOAJ |
| description | Acute megakaryoblastic leukemia (AML-M7) is rarely seen in adult patients and patients usually present with cytopenias. Here we discuss diagnostic challenges and pathologic features in a patient with AML-M7 who presented with thrombocytosis and diarrhea. A 63-year-old male patient presented with persistent diarrhea lasting for 2 months, fatigue, and thrombocytosis. The diagnostic workup included a stool analysis, endoscopy colonoscopy, and imaging studies; however, these studies did not reveal any possible etiology. The hematologic evaluation included peripheral blood smear, bone marrow aspiration and biopsy, flow cytometry, and cytogenetic analysis. Eventually, according to pathologic and flow cytometric findings, a diagnosis of AML-M7 was made. Diagnosis of AML-M7 may be challenging, especially in adult patients with atypical presentation. Patients with megakaryoblastic leukemia respond poorly to standard induction regimens and they should be advised to participate in a clinical trial. |
| format | Article |
| id | doaj-art-64eb8c383b7140249d4935021c88b777 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-64eb8c383b7140249d4935021c88b7772025-02-07T14:00:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167242542710.4103/ijpm.ijpm_233_22Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual caseNevin Alayvaz AslanGülsün GültenAcute megakaryoblastic leukemia (AML-M7) is rarely seen in adult patients and patients usually present with cytopenias. Here we discuss diagnostic challenges and pathologic features in a patient with AML-M7 who presented with thrombocytosis and diarrhea. A 63-year-old male patient presented with persistent diarrhea lasting for 2 months, fatigue, and thrombocytosis. The diagnostic workup included a stool analysis, endoscopy colonoscopy, and imaging studies; however, these studies did not reveal any possible etiology. The hematologic evaluation included peripheral blood smear, bone marrow aspiration and biopsy, flow cytometry, and cytogenetic analysis. Eventually, according to pathologic and flow cytometric findings, a diagnosis of AML-M7 was made. Diagnosis of AML-M7 may be challenging, especially in adult patients with atypical presentation. Patients with megakaryoblastic leukemia respond poorly to standard induction regimens and they should be advised to participate in a clinical trial.https://journals.lww.com/10.4103/ijpm.ijpm_233_22diarrhealeukemiamegakaryoblastthrombocytosis |
| spellingShingle | Nevin Alayvaz Aslan Gülsün Gülten Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case Indian Journal of Pathology and Microbiology diarrhea leukemia megakaryoblast thrombocytosis |
| title | Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case |
| title_full | Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case |
| title_fullStr | Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case |
| title_full_unstemmed | Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case |
| title_short | Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case |
| title_sort | adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis a very unusual case |
| topic | diarrhea leukemia megakaryoblast thrombocytosis |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_233_22 |
| work_keys_str_mv | AT nevinalayvazaslan adultacutemegakaryoblasticleukemiawithpersistentdiarrheaandextremethrombocytosisaveryunusualcase AT gulsungulten adultacutemegakaryoblasticleukemiawithpersistentdiarrheaandextremethrombocytosisaveryunusualcase |