Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds
Abstract Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong...
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| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03175-7 |
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| author | Rui Lei Wenjun Wang Guan Li Qian Yu Haowei Fang Jinghong Xu Kunxi Zhang Yinghai Ye |
| author_facet | Rui Lei Wenjun Wang Guan Li Qian Yu Haowei Fang Jinghong Xu Kunxi Zhang Yinghai Ye |
| author_sort | Rui Lei |
| collection | DOAJ |
| description | Abstract Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for emergency treatment of trauma in maritime activities. The bioadhesives are fabricated from the aggregation of LA, MXene and Ag+ through their supramolecular interactions, which can be rapidly formed in mild environments, showing strong interface adhesion without adhesive failure caused by depolymerization, while exhibiting mechanical self-reinforcing. To further improve the adhesive strength, the formation of MXene/Ag+/LA interactions was integrated into poly(2-hydroxyethyl methacrylate) (pHEMA) electrospinning to manufacture electrospun film with the adhesion strength as high as 2 MPa. The bioadhesives are sensitive to alkaline environments and can lead to deprotonation of LA. The released H+ can instantly adjust the pH of weakly alkaline seawater-immersed wounds to normal pH, while deprotonated LA is released into wounds to exert anti-inflammatory functions. Together with antibacterial property, bioadhesives applied to seawater-immersed wounds provide stable barrier protection and correct adverse microenvironment, promoting wound healing. |
| format | Article |
| id | doaj-art-6508971dc23e4231a3e001c7e7b3796e |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-6508971dc23e4231a3e001c7e7b3796e2025-02-09T12:52:57ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123111810.1186/s12951-025-03175-7Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed woundsRui Lei0Wenjun Wang1Guan Li2Qian Yu3Haowei Fang4Jinghong Xu5Kunxi Zhang6Yinghai Ye7Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Medical Aesthetic, The Dingli Clinical College of Wenzhou Medical University, Wenzhou Central Hospital)Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Medical Aesthetic, The Dingli Clinical College of Wenzhou Medical University, Wenzhou Central Hospital)Abstract Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for emergency treatment of trauma in maritime activities. The bioadhesives are fabricated from the aggregation of LA, MXene and Ag+ through their supramolecular interactions, which can be rapidly formed in mild environments, showing strong interface adhesion without adhesive failure caused by depolymerization, while exhibiting mechanical self-reinforcing. To further improve the adhesive strength, the formation of MXene/Ag+/LA interactions was integrated into poly(2-hydroxyethyl methacrylate) (pHEMA) electrospinning to manufacture electrospun film with the adhesion strength as high as 2 MPa. The bioadhesives are sensitive to alkaline environments and can lead to deprotonation of LA. The released H+ can instantly adjust the pH of weakly alkaline seawater-immersed wounds to normal pH, while deprotonated LA is released into wounds to exert anti-inflammatory functions. Together with antibacterial property, bioadhesives applied to seawater-immersed wounds provide stable barrier protection and correct adverse microenvironment, promoting wound healing.https://doi.org/10.1186/s12951-025-03175-7MXeneLipoic acidSupramolecular interactionBioadhesiveSeawater-immersed wound |
| spellingShingle | Rui Lei Wenjun Wang Guan Li Qian Yu Haowei Fang Jinghong Xu Kunxi Zhang Yinghai Ye Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds Journal of Nanobiotechnology MXene Lipoic acid Supramolecular interaction Bioadhesive Seawater-immersed wound |
| title | Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds |
| title_full | Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds |
| title_fullStr | Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds |
| title_full_unstemmed | Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds |
| title_short | Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds |
| title_sort | supramolecular interactions driven aggregation to prepare lipoic acid bioadhesives for seawater immersed wounds |
| topic | MXene Lipoic acid Supramolecular interaction Bioadhesive Seawater-immersed wound |
| url | https://doi.org/10.1186/s12951-025-03175-7 |
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