Comprehensive analysis of α2,3-sialyltransferases as prognostic biomarkers and immunotherapy targets in kidney renal clear cell carcinoma

Comprehensive analysis of α2,3-sialyltransferases as prognostic biomarkers and immunotherapy targets in kidney renal clear cell carcinoma

Abstract Kidney renal clear cell carcinoma (KIRC), a therapy-resistant aggressive kidney cancer, exhibits resistance to immune checkpoint inhibitors. Altered sialylation is involved in tumor development, affecting immune microenvironment dynamics. In the study, through systematic bioinformatics anal...

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Bibliographic Details
Main Authors: Yuli Jian, Kangkang Yang, Jinjing Li, Ling Tang, Guang Zeng, Xiaoxin Sun, Xiao Yu, Abdullah Al-danakh, Qiwei Chen, Deyong Yang, Shujing Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Cell International
Subjects:
Kidney renal clear cell carcinoma
ST3Gals
Tumor immune microenvironment
Immunotherapy
Prognostic biomarkers
Online Access:https://doi.org/10.1186/s12935-025-03640-1
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