Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer
Abstract The development of metastasis is a leading cause of cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus of cancer cells. Elevated levels of membrane lipids, including sphingomyelin, cholesterol, and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), i...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-025-02452-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861642940645376 |
|---|---|
| author | Agnieszka Chytła Stephanie Rattay Baki Akgül Martin Sztacho |
| author_facet | Agnieszka Chytła Stephanie Rattay Baki Akgül Martin Sztacho |
| author_sort | Agnieszka Chytła |
| collection | DOAJ |
| description | Abstract The development of metastasis is a leading cause of cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus of cancer cells. Elevated levels of membrane lipids, including sphingomyelin, cholesterol, and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), in the PM, contribute to changes in membrane rigidity, lipid raft formation, and actin polymerisation dynamics, processes that drive cell invasion. This review discusses the relationship between well-studied cytoplasmic phosphoinositides and their lesser-known nuclear counterparts, highlighting their functional role in metastatic progression. Nuclear phosphoinositides, particularly PI(4,5)P2, are essential for regulating transcription factors and chromatin organisation, thereby shaping gene expression patterns. We also explore the role of PI(4,5)P2 and its metabolism in cancer cell invasiveness and metastasis, proposing a model in which the dysregulation of cytosolic and/or nuclear PI(4,5)P2 pool triggers malignant transformation. Understanding the PI(4,5)P2-related mechanisms underlying metastasis may provide insights into potential therapeutic targets, paving the way for more effective therapies and improved patient outcomes. |
| format | Article |
| id | doaj-art-66c8d82944e447bf832d8a742f9c7a9d |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-66c8d82944e447bf832d8a742f9c7a9d2025-02-09T12:52:36ZengBMCLipids in Health and Disease1476-511X2025-02-0124111110.1186/s12944-025-02452-6Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancerAgnieszka Chytła0Stephanie Rattay1Baki Akgül2Martin Sztacho3Laboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles UniversityInstitute of Virology, Medical Faculty, University of Cologne, University Hospital CologneInstitute of Virology, Medical Faculty, University of Cologne, University Hospital CologneLaboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles UniversityAbstract The development of metastasis is a leading cause of cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus of cancer cells. Elevated levels of membrane lipids, including sphingomyelin, cholesterol, and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), in the PM, contribute to changes in membrane rigidity, lipid raft formation, and actin polymerisation dynamics, processes that drive cell invasion. This review discusses the relationship between well-studied cytoplasmic phosphoinositides and their lesser-known nuclear counterparts, highlighting their functional role in metastatic progression. Nuclear phosphoinositides, particularly PI(4,5)P2, are essential for regulating transcription factors and chromatin organisation, thereby shaping gene expression patterns. We also explore the role of PI(4,5)P2 and its metabolism in cancer cell invasiveness and metastasis, proposing a model in which the dysregulation of cytosolic and/or nuclear PI(4,5)P2 pool triggers malignant transformation. Understanding the PI(4,5)P2-related mechanisms underlying metastasis may provide insights into potential therapeutic targets, paving the way for more effective therapies and improved patient outcomes.https://doi.org/10.1186/s12944-025-02452-6Phosphatidylinositol 4,5-bisphosphateNucleusBiocondensatesCancerMetastasisHPV |
| spellingShingle | Agnieszka Chytła Stephanie Rattay Baki Akgül Martin Sztacho Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer Lipids in Health and Disease Phosphatidylinositol 4,5-bisphosphate Nucleus Biocondensates Cancer Metastasis HPV |
| title | Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer |
| title_full | Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer |
| title_fullStr | Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer |
| title_full_unstemmed | Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer |
| title_short | Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer |
| title_sort | plasma membrane and nuclear phosphatidylinositol 4 5 bisphosphate signalling in cancer |
| topic | Phosphatidylinositol 4,5-bisphosphate Nucleus Biocondensates Cancer Metastasis HPV |
| url | https://doi.org/10.1186/s12944-025-02452-6 |
| work_keys_str_mv | AT agnieszkachytła plasmamembraneandnuclearphosphatidylinositol45bisphosphatesignallingincancer AT stephanierattay plasmamembraneandnuclearphosphatidylinositol45bisphosphatesignallingincancer AT bakiakgul plasmamembraneandnuclearphosphatidylinositol45bisphosphatesignallingincancer AT martinsztacho plasmamembraneandnuclearphosphatidylinositol45bisphosphatesignallingincancer |