Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer
Abstract A sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve. The hedgehog signaling pathway, a critical medi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-02-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02327-w |
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| _version_ | 1823863275275681792 |
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| author | Ge Cong Xingyu Zhu Xin Ru Chen Hao Chen Wei Chong |
| author_facet | Ge Cong Xingyu Zhu Xin Ru Chen Hao Chen Wei Chong |
| author_sort | Ge Cong |
| collection | DOAJ |
| description | Abstract A sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve. The hedgehog signaling pathway, a critical mediator in the normal development of numerous organs and the pathogenesis of cancer, is typically quiescent but is aberrantly activated in several malignancies. Extensive research has delineated that the aberrant activity of the hedgehog signaling pathway, whether autocrine or paracrine, is implicated in the initiation and progression of various neoplasms, including medulloblastoma (MB), basal cell carcinoma (BCC) and so on. Thus, notably Smo inhibitors, the opening of inhibitors of the hedgehog signaling pathway has become a topic of research attention. This review aims to summarize four aberrant activation pathways and the influence of hedgehog signaling pathway associated chemicals on tumor formation and development. Additionally, it will explore the therapeutic potential of targeted interventions in the hedgehog signaling pathway for cancer treatment. |
| format | Article |
| id | doaj-art-66eb8538dbf049308a7495e236906aa5 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-66eb8538dbf049308a7495e236906aa52025-02-09T12:12:29ZengNature Publishing GroupCell Death Discovery2058-77162025-02-0111111210.1038/s41420-025-02327-wMechanisms and therapeutic potential of the hedgehog signaling pathway in cancerGe Cong0Xingyu Zhu1Xin Ru Chen2Hao Chen3Wei Chong4Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityClinical Research Center of Shandong University, Clinical Epidemiology Unit, Qilu Hospital of Shandong UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract A sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve. The hedgehog signaling pathway, a critical mediator in the normal development of numerous organs and the pathogenesis of cancer, is typically quiescent but is aberrantly activated in several malignancies. Extensive research has delineated that the aberrant activity of the hedgehog signaling pathway, whether autocrine or paracrine, is implicated in the initiation and progression of various neoplasms, including medulloblastoma (MB), basal cell carcinoma (BCC) and so on. Thus, notably Smo inhibitors, the opening of inhibitors of the hedgehog signaling pathway has become a topic of research attention. This review aims to summarize four aberrant activation pathways and the influence of hedgehog signaling pathway associated chemicals on tumor formation and development. Additionally, it will explore the therapeutic potential of targeted interventions in the hedgehog signaling pathway for cancer treatment.https://doi.org/10.1038/s41420-025-02327-w |
| spellingShingle | Ge Cong Xingyu Zhu Xin Ru Chen Hao Chen Wei Chong Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer Cell Death Discovery |
| title | Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer |
| title_full | Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer |
| title_fullStr | Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer |
| title_full_unstemmed | Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer |
| title_short | Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer |
| title_sort | mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer |
| url | https://doi.org/10.1038/s41420-025-02327-w |
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