Inducers of Autophagy and Cell Death: Focus on Copper Metabolism
Copper is an essential trace element in biological systems, playing a key role in various physiological functions, including redox reactions and energy metabolism. However, an imbalance in copper homeostasis can induce oxidative stress, mitochondrial dysfunction, and inhibition of the ubiquitin-prot...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000612 |
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| author | Weikang Ling Shuo Li Yang Zhu Xin Wang Dongmei Jiang Bo Kang |
| author_facet | Weikang Ling Shuo Li Yang Zhu Xin Wang Dongmei Jiang Bo Kang |
| author_sort | Weikang Ling |
| collection | DOAJ |
| description | Copper is an essential trace element in biological systems, playing a key role in various physiological functions, including redox reactions and energy metabolism. However, an imbalance in copper homeostasis can induce oxidative stress, mitochondrial dysfunction, and inhibition of the ubiquitin-proteasome system, ultimately leading to significant cytotoxicity and cell death. According to recent research, copper can bind to lipoylation sites on proteins involved in the tricarboxylic acid cycle, causing aggregation of lipoylated proteins, the loss of Fe-S cluster proteins, proteotoxic stress, and ultimately, cell death. This new type of programmed cell death is called “Cuproptosis”. Furthermore, autophagy may be activated by a disruption in copper homeostasis, while it plays a dual role in regulating copper-induced cell death by acting both as an inhibitor of cell death and as a promoter of cytotoxicity. This review summarizes research progress on copper metabolic patterns, molecular mechanisms of copper-induced cell death, and mechanisms of copper-induced autophagy-cytotoxicity interactions. Meanwhile, the application of copper-induced cell death in cancer therapy is discussed, aiming to provide new insights and guiding future research toward advancing cancer therapy. |
| format | Article |
| id | doaj-art-68cfbb33b80043d2a136b2d6d9bf6d5f |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-68cfbb33b80043d2a136b2d6d9bf6d5f2025-02-12T05:30:06ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117725Inducers of Autophagy and Cell Death: Focus on Copper MetabolismWeikang Ling0Shuo Li1Yang Zhu2Xin Wang3Dongmei Jiang4Bo Kang5State Key Laboratory of Swine and Poultry Breeding Industry, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chendu 611130, PR ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chendu 611130, PR ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chendu 611130, PR ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chendu 611130, PR ChinaCorrespondence to: College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.; State Key Laboratory of Swine and Poultry Breeding Industry, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chendu 611130, PR ChinaCorrespondence to: College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.; State Key Laboratory of Swine and Poultry Breeding Industry, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chendu 611130, PR ChinaCopper is an essential trace element in biological systems, playing a key role in various physiological functions, including redox reactions and energy metabolism. However, an imbalance in copper homeostasis can induce oxidative stress, mitochondrial dysfunction, and inhibition of the ubiquitin-proteasome system, ultimately leading to significant cytotoxicity and cell death. According to recent research, copper can bind to lipoylation sites on proteins involved in the tricarboxylic acid cycle, causing aggregation of lipoylated proteins, the loss of Fe-S cluster proteins, proteotoxic stress, and ultimately, cell death. This new type of programmed cell death is called “Cuproptosis”. Furthermore, autophagy may be activated by a disruption in copper homeostasis, while it plays a dual role in regulating copper-induced cell death by acting both as an inhibitor of cell death and as a promoter of cytotoxicity. This review summarizes research progress on copper metabolic patterns, molecular mechanisms of copper-induced cell death, and mechanisms of copper-induced autophagy-cytotoxicity interactions. Meanwhile, the application of copper-induced cell death in cancer therapy is discussed, aiming to provide new insights and guiding future research toward advancing cancer therapy.http://www.sciencedirect.com/science/article/pii/S0147651325000612Copper homeostasisCopper metabolismCell deathAutophagyCancer treatment |
| spellingShingle | Weikang Ling Shuo Li Yang Zhu Xin Wang Dongmei Jiang Bo Kang Inducers of Autophagy and Cell Death: Focus on Copper Metabolism Ecotoxicology and Environmental Safety Copper homeostasis Copper metabolism Cell death Autophagy Cancer treatment |
| title | Inducers of Autophagy and Cell Death: Focus on Copper Metabolism |
| title_full | Inducers of Autophagy and Cell Death: Focus on Copper Metabolism |
| title_fullStr | Inducers of Autophagy and Cell Death: Focus on Copper Metabolism |
| title_full_unstemmed | Inducers of Autophagy and Cell Death: Focus on Copper Metabolism |
| title_short | Inducers of Autophagy and Cell Death: Focus on Copper Metabolism |
| title_sort | inducers of autophagy and cell death focus on copper metabolism |
| topic | Copper homeostasis Copper metabolism Cell death Autophagy Cancer treatment |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000612 |
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