Epigenetics of cancer drug resistance
One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells. There are multiple evidences which suggest that malfunction of epigenetic regulation in functioning...
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| Format: | Article |
| Language: | English |
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Academia.edu Journals
2023-07-01
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| Series: | Academia Biology |
| Online Access: | https://www.academia.edu/104666574/Epigenetics_of_cancer_drug_resistance |
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| author | Sayandeep Mukherjee Ronit Dey Subhabrata Guha Nabendu Murmu Gaurav Das |
| author_facet | Sayandeep Mukherjee Ronit Dey Subhabrata Guha Nabendu Murmu Gaurav Das |
| author_sort | Sayandeep Mukherjee |
| collection | DOAJ |
| description |
One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells. There are multiple evidences which suggest that malfunction of epigenetic regulation in functioning of a gene is directly related to the development of cancer. The capability to change or reprogram the landscape of epigenetics in the epigenome of cancer is the most promising and guaranteed targeted therapy that leads to the reversibility of drug resistance and new modalities of treatment in cancer. This review clearly focuses on various epigenetic modifications which leads to antitumor drug resistance and how epigenetic modifiers can reverse drug resistance. |
| format | Article |
| id | doaj-art-6a2a0984b4b94754993d922da2c4593b |
| institution | Kabale University |
| issn | 2837-4010 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Academia.edu Journals |
| record_format | Article |
| series | Academia Biology |
| spelling | doaj-art-6a2a0984b4b94754993d922da2c4593b2025-02-11T23:53:06ZengAcademia.edu JournalsAcademia Biology2837-40102023-07-011310.20935/AcadBiol6079Epigenetics of cancer drug resistanceSayandeep Mukherjee0Ronit Dey1Subhabrata Guha2Nabendu Murmu3Gaurav Das4Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India.Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India.Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India.Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India.Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India. One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells. There are multiple evidences which suggest that malfunction of epigenetic regulation in functioning of a gene is directly related to the development of cancer. The capability to change or reprogram the landscape of epigenetics in the epigenome of cancer is the most promising and guaranteed targeted therapy that leads to the reversibility of drug resistance and new modalities of treatment in cancer. This review clearly focuses on various epigenetic modifications which leads to antitumor drug resistance and how epigenetic modifiers can reverse drug resistance.https://www.academia.edu/104666574/Epigenetics_of_cancer_drug_resistance |
| spellingShingle | Sayandeep Mukherjee Ronit Dey Subhabrata Guha Nabendu Murmu Gaurav Das Epigenetics of cancer drug resistance Academia Biology |
| title | Epigenetics of cancer drug resistance |
| title_full | Epigenetics of cancer drug resistance |
| title_fullStr | Epigenetics of cancer drug resistance |
| title_full_unstemmed | Epigenetics of cancer drug resistance |
| title_short | Epigenetics of cancer drug resistance |
| title_sort | epigenetics of cancer drug resistance |
| url | https://www.academia.edu/104666574/Epigenetics_of_cancer_drug_resistance |
| work_keys_str_mv | AT sayandeepmukherjee epigeneticsofcancerdrugresistance AT ronitdey epigeneticsofcancerdrugresistance AT subhabrataguha epigeneticsofcancerdrugresistance AT nabendumurmu epigeneticsofcancerdrugresistance AT gauravdas epigeneticsofcancerdrugresistance |