Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam
Background: Multidrug resistant (MDR) Gram negative organisms are becoming increasingly common. Carbapenem resistant Enterobacterales (CRE) pose a major threat and necessitate the development of new antibiotics. MDR and carbapenem resistant infections, which are common in intensive care units and ho...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1272_24 |
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| author | Sunali Mithilesh Kumar Jha Mukesh Kumar Maneesh Kumar Nishant Ranjan |
| author_facet | Sunali Mithilesh Kumar Jha Mukesh Kumar Maneesh Kumar Nishant Ranjan |
| author_sort | Sunali |
| collection | DOAJ |
| description | Background:
Multidrug resistant (MDR) Gram negative organisms are becoming increasingly common. Carbapenem resistant Enterobacterales (CRE) pose a major threat and necessitate the development of new antibiotics. MDR and carbapenem resistant infections, which are common in intensive care units and hospitals, lead to increased morbidity, mortality, prolonged hospital stays, and higher healthcare costs. New antimicrobials such as ceftazidime avibactam offer potential alternatives to conventional treatments such as tigecycline and colistin, which have significant side effects and limitations.
Aim:
This study focuses on the antibiotic susceptibility of ceftazidime/ avibactam to Gram negative bacilli found in a large number of clinical samples collected from a tertiary care facility in Netaji Subhas Medical University and Hospital, Bihta, India.
Methodology:
The study included 81 Gram negative bacteria isolated from patient samples. Based on the Clinical Laboratory Standards Institute guidelines mentioned in the Kirby Bauer disc diffusion method.
Result and Conclusion:
the results showed that ceftazidime avibactam inhibited 89.9% of the Enterobacteriaceae isolates, which was higher than the 80.3% of amikacin and the 85.1% of meropenem. Ceftazidime avibactam was effective against CRE isolates in 69.9% of cases and against MDR isolates in urine in 94% of cases, which was higher than the 40% of ceftriaxone and 94% of nitrofurantoin. The results show that ceftazidime avibactam can cure MDR and CRE infections, especially urinary tract infections, better than conventional antibiotics, which is a great help in the fight against increasing antibiotic resistance. |
| format | Article |
| id | doaj-art-6aa432bf1c834f63bd2c2574b192b300 |
| institution | Kabale University |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-6aa432bf1c834f63bd2c2574b192b3002025-02-11T13:53:51ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352025-01-0114131131610.4103/jfmpc.jfmpc_1272_24Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactamSunaliMithilesh Kumar JhaMukesh KumarManeesh KumarNishant RanjanBackground: Multidrug resistant (MDR) Gram negative organisms are becoming increasingly common. Carbapenem resistant Enterobacterales (CRE) pose a major threat and necessitate the development of new antibiotics. MDR and carbapenem resistant infections, which are common in intensive care units and hospitals, lead to increased morbidity, mortality, prolonged hospital stays, and higher healthcare costs. New antimicrobials such as ceftazidime avibactam offer potential alternatives to conventional treatments such as tigecycline and colistin, which have significant side effects and limitations. Aim: This study focuses on the antibiotic susceptibility of ceftazidime/ avibactam to Gram negative bacilli found in a large number of clinical samples collected from a tertiary care facility in Netaji Subhas Medical University and Hospital, Bihta, India. Methodology: The study included 81 Gram negative bacteria isolated from patient samples. Based on the Clinical Laboratory Standards Institute guidelines mentioned in the Kirby Bauer disc diffusion method. Result and Conclusion: the results showed that ceftazidime avibactam inhibited 89.9% of the Enterobacteriaceae isolates, which was higher than the 80.3% of amikacin and the 85.1% of meropenem. Ceftazidime avibactam was effective against CRE isolates in 69.9% of cases and against MDR isolates in urine in 94% of cases, which was higher than the 40% of ceftriaxone and 94% of nitrofurantoin. The results show that ceftazidime avibactam can cure MDR and CRE infections, especially urinary tract infections, better than conventional antibiotics, which is a great help in the fight against increasing antibiotic resistance.https://journals.lww.com/10.4103/jfmpc.jfmpc_1272_24carbapenem-resistantceftazidime-avibactamenterobacteralesgram-negative bacillikirby-bauer disc diffusionmultidrug-resistant |
| spellingShingle | Sunali Mithilesh Kumar Jha Mukesh Kumar Maneesh Kumar Nishant Ranjan Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam Journal of Family Medicine and Primary Care carbapenem-resistant ceftazidime-avibactam enterobacterales gram-negative bacilli kirby-bauer disc diffusion multidrug-resistant |
| title | Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam |
| title_full | Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam |
| title_fullStr | Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam |
| title_full_unstemmed | Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam |
| title_short | Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam |
| title_sort | investigating gram negative bacilli isolates sensitivity to ceftazidime avibactam |
| topic | carbapenem-resistant ceftazidime-avibactam enterobacterales gram-negative bacilli kirby-bauer disc diffusion multidrug-resistant |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_1272_24 |
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