Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease
Background. Non-alcoholic fatty liver disease (NAFLD) is the leading chronic hepatic condition worldwide and new approaches to management and treatment are limited.Summary. L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of...
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Gastro LLC
2019-03-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/322 |
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| author | Roger F. Butterworth Ali Canbay |
| author_facet | Roger F. Butterworth Ali Canbay |
| author_sort | Roger F. Butterworth |
| collection | DOAJ |
| description | Background. Non-alcoholic fatty liver disease (NAFLD) is the leading chronic hepatic condition worldwide and new approaches to management and treatment are limited.Summary. L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. A preliminary report described improvements of hepatic microcirculation in patients with nonalcoholic steatohepatitis (NASH) following treatment with LOLA. Mechanisms responsible for the beneficial effects of LOLA in NAFLD/NASH involve, in addition to its established ammonia-lowering effect, metabolic transformations of the LOLA-constituent amino acids L-ornithine and L-aspartate into L-glutamine, L-arginine, and glutathione. These metabolites have well-established actions implicated in the prevention of lipid peroxidation, improvement of hepatic microcirculation in addition to anti-inflammatory, and anti-oxidant properties.Key messages. (1) LOLA is effective for the treatment of key indices in NAFLD/NASH. (2) Mechanisms other than LOLA’s ammonia-lowering action have been postulated. (3) Further assessments in the clinical setting are now required. |
| format | Article |
| id | doaj-art-6cfd287a2ec943f1975a67eae32f2822 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-6cfd287a2ec943f1975a67eae32f28222025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732019-03-01291243010.22416/1382-4376-2019-29-1-24-30282Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver DiseaseRoger F. Butterworth0Ali Canbay1University of Montreal (St-Luc Hospital), Montreal, QCUniversity of Magdeburg (University Hospital), MagdeburgBackground. Non-alcoholic fatty liver disease (NAFLD) is the leading chronic hepatic condition worldwide and new approaches to management and treatment are limited.Summary. L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. A preliminary report described improvements of hepatic microcirculation in patients with nonalcoholic steatohepatitis (NASH) following treatment with LOLA. Mechanisms responsible for the beneficial effects of LOLA in NAFLD/NASH involve, in addition to its established ammonia-lowering effect, metabolic transformations of the LOLA-constituent amino acids L-ornithine and L-aspartate into L-glutamine, L-arginine, and glutathione. These metabolites have well-established actions implicated in the prevention of lipid peroxidation, improvement of hepatic microcirculation in addition to anti-inflammatory, and anti-oxidant properties.Key messages. (1) LOLA is effective for the treatment of key indices in NAFLD/NASH. (2) Mechanisms other than LOLA’s ammonia-lowering action have been postulated. (3) Further assessments in the clinical setting are now required.https://www.gastro-j.ru/jour/article/view/322l-ornithine l-aspartatenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitishepatoprotectionantioxidanthepatic microcirculationglutamine |
| spellingShingle | Roger F. Butterworth Ali Canbay Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии l-ornithine l-aspartate non-alcoholic fatty liver disease non-alcoholic steatohepatitis hepatoprotection antioxidant hepatic microcirculation glutamine |
| title | Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease |
| title_full | Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease |
| title_fullStr | Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease |
| title_short | Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease |
| title_sort | hepatoprotection by l ornithine l aspartate in non alcoholic fatty liver disease |
| topic | l-ornithine l-aspartate non-alcoholic fatty liver disease non-alcoholic steatohepatitis hepatoprotection antioxidant hepatic microcirculation glutamine |
| url | https://www.gastro-j.ru/jour/article/view/322 |
| work_keys_str_mv | AT rogerfbutterworth hepatoprotectionbylornithinelaspartateinnonalcoholicfattyliverdisease AT alicanbay hepatoprotectionbylornithinelaspartateinnonalcoholicfattyliverdisease |