Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction
Background and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices, have been explored as alternative therapies...
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001672 |
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| author | Etukudo Okon Jimmy Grace Edet Bassey Abijah Ekwere Udoh Idorenyin Umoh Adeyemi Fatai Odetayo Udoh Nsikan Malachy |
| author_facet | Etukudo Okon Jimmy Grace Edet Bassey Abijah Ekwere Udoh Idorenyin Umoh Adeyemi Fatai Odetayo Udoh Nsikan Malachy |
| author_sort | Etukudo Okon Jimmy |
| collection | DOAJ |
| description | Background and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices, have been explored as alternative therapies for ED, and this study focuses on Uvara chemea and Cylicodiscus gabunensis, two plants with reported medicinal properties, as potential alternatives to sildenafil, a standard pharmaceutical for ED. Experimental procedure: Forty male Wistar rats were randomly divided into five groups: control (treated with distilled water), low, medium, and high doses (treated with 61.23, 122.47, and 183.71 mg/kg each of Uvara chemea and Cylicodiscus gabunensis respectively), and a positive control group (treated with sildenafil citrate). The rats were treated for 21 days, and their erectile responses were estimated Results: Significant improvements in erectile responses were observed in rats treated with Uvara chemea and Cylicodiscus gabunensis extracts compared to the control group. When compared to sildenafil citrate, the extracts showed comparable effects in most parameters, with a significant disparity noted in intromission frequency at low and high dosages. Strikingly, there was no significant difference between the extracts treated animals and their counterparts treated with sildenafil citrate. Conclusion: Uvara chemea and Cylicodiscus gabunensis extracts demonstrated potential in ameliorating erectile dysfunction in rats, suggesting their viability as alternative or complementary therapeutic options to sildenafil citrate. Further investigations are necessary to elucidate the underlying mechanisms of action, determine optimal dosages, and evaluate the long-term safety profiles of these herbal extracts for potential human applications. |
| format | Article |
| id | doaj-art-6dbdacea7aee424fa5b662a5e6c3b310 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-6dbdacea7aee424fa5b662a5e6c3b3102025-02-10T04:35:09ZengElsevierPhytomedicine Plus2667-03132025-02-0151100693Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunctionEtukudo Okon Jimmy0Grace Edet Bassey1Abijah Ekwere2Udoh Idorenyin Umoh3Adeyemi Fatai Odetayo4Udoh Nsikan Malachy5Department of Medical Physiology, Faculty of Basic Medical Sciences, University of Uyo, Nigeria; Corresponding author at: Department of Medical Physiology, Faculty of Basic Medical Sciences, University of Uyo, Nigeria.Department of Medical Physiology, Faculty of Basic Medical Sciences, University of Uyo, NigeriaDepartment of Medical Physiology, Faculty of Basic Medical Sciences, University of Uyo, NigeriaDepartment of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila-Orangun, NigeriaDepartment of Pharmacognosy, Faculty of Pharmacy, University of Uyo, NigeriaBackground and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices, have been explored as alternative therapies for ED, and this study focuses on Uvara chemea and Cylicodiscus gabunensis, two plants with reported medicinal properties, as potential alternatives to sildenafil, a standard pharmaceutical for ED. Experimental procedure: Forty male Wistar rats were randomly divided into five groups: control (treated with distilled water), low, medium, and high doses (treated with 61.23, 122.47, and 183.71 mg/kg each of Uvara chemea and Cylicodiscus gabunensis respectively), and a positive control group (treated with sildenafil citrate). The rats were treated for 21 days, and their erectile responses were estimated Results: Significant improvements in erectile responses were observed in rats treated with Uvara chemea and Cylicodiscus gabunensis extracts compared to the control group. When compared to sildenafil citrate, the extracts showed comparable effects in most parameters, with a significant disparity noted in intromission frequency at low and high dosages. Strikingly, there was no significant difference between the extracts treated animals and their counterparts treated with sildenafil citrate. Conclusion: Uvara chemea and Cylicodiscus gabunensis extracts demonstrated potential in ameliorating erectile dysfunction in rats, suggesting their viability as alternative or complementary therapeutic options to sildenafil citrate. Further investigations are necessary to elucidate the underlying mechanisms of action, determine optimal dosages, and evaluate the long-term safety profiles of these herbal extracts for potential human applications.http://www.sciencedirect.com/science/article/pii/S2667031324001672IntromissionUvaria chemeaCylicodiscus gabunensisMountPenile erectionSexual behavior |
| spellingShingle | Etukudo Okon Jimmy Grace Edet Bassey Abijah Ekwere Udoh Idorenyin Umoh Adeyemi Fatai Odetayo Udoh Nsikan Malachy Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction Phytomedicine Plus Intromission Uvaria chemea Cylicodiscus gabunensis Mount Penile erection Sexual behavior |
| title | Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction |
| title_full | Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction |
| title_fullStr | Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction |
| title_full_unstemmed | Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction |
| title_short | Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction |
| title_sort | finger roots uvaria chemea and african greenheart cylicodiscus gabunensis alternative potent therapy to sildenafil in erectile dysfunction |
| topic | Intromission Uvaria chemea Cylicodiscus gabunensis Mount Penile erection Sexual behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001672 |
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