The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function
Abstract Background Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. While long-term outcomes such as patient and allograft survival are...
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2025-02-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-03989-5 |
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| author | Christian Kuhn Bernd Jänigen Laura Matuschik Max J. Rieger Daniel Sidler Stefan Zschiedrich |
| author_facet | Christian Kuhn Bernd Jänigen Laura Matuschik Max J. Rieger Daniel Sidler Stefan Zschiedrich |
| author_sort | Christian Kuhn |
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| description | Abstract Background Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. While long-term outcomes such as patient and allograft survival are well studied, the impact of lymphocele formation on mid-term allograft function remains unclear. Methods This multicentric study included 711 recipients of living donor kidney transplants to investigate the impact of lymphocele formation on mid-term graft function. Outcomes assessed included estimated glomerular filtration rate (eGFR) at 12 months, eGFR slope, and both patient and allograft survival. Results Lymphoceles were detected in 17.4% of the recipients, with a median volume of 129 ml, and 71.8% of these patients required intervention. Patients without lymphocele formation had a significantly higher median eGFR at 12 months (52.1 ml/min/1.73 m²) compared to those with lymphoceles (48.7 ml/min/1.73 m²). Additionally, patients with lymphocele formation demonstrated a steeper median eGFR slope (-2.3 ml/min/1.73 m²/year) than those without (-0.3 ml/min/1.73 m²/year). No significant difference was observed in the composite outcome of allograft survival and patient death between the two groups. Conclusion Lymphocele formation after living donor kidney transplantation is associated with a steeper decline in graft function. They may reflect a disturbed microvasculature and warrant closer control of cardiovascular risk factors and allograft monitoring of affected patients. Clinical trial details Not applicable, the study is not a clinical trial. |
| format | Article |
| id | doaj-art-6e74ef218fd1471488d80984d1ed726b |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Nephrology |
| spelling | doaj-art-6e74ef218fd1471488d80984d1ed726b2025-02-09T12:16:55ZengBMCBMC Nephrology1471-23692025-02-012611810.1186/s12882-025-03989-5The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft functionChristian Kuhn0Bernd Jänigen1Laura Matuschik2Max J. Rieger3Daniel Sidler4Stefan Zschiedrich5Division of Nephrology and Transplantation Medicine, Kantonsspital St. GallenDepartment of General and Digestive Surgery, Medical Centre, University of FreiburgDepartment of General and Digestive Surgery, Medical Centre, University of FreiburgDepartment of Medical Oncology and Hematology, University Hospital of ZurichDepartment of Nephrology and Hypertension, Inselspital, Bern University HospitalDepartment of Internal Medicine, Bürgerspital SolothurnAbstract Background Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. While long-term outcomes such as patient and allograft survival are well studied, the impact of lymphocele formation on mid-term allograft function remains unclear. Methods This multicentric study included 711 recipients of living donor kidney transplants to investigate the impact of lymphocele formation on mid-term graft function. Outcomes assessed included estimated glomerular filtration rate (eGFR) at 12 months, eGFR slope, and both patient and allograft survival. Results Lymphoceles were detected in 17.4% of the recipients, with a median volume of 129 ml, and 71.8% of these patients required intervention. Patients without lymphocele formation had a significantly higher median eGFR at 12 months (52.1 ml/min/1.73 m²) compared to those with lymphoceles (48.7 ml/min/1.73 m²). Additionally, patients with lymphocele formation demonstrated a steeper median eGFR slope (-2.3 ml/min/1.73 m²/year) than those without (-0.3 ml/min/1.73 m²/year). No significant difference was observed in the composite outcome of allograft survival and patient death between the two groups. Conclusion Lymphocele formation after living donor kidney transplantation is associated with a steeper decline in graft function. They may reflect a disturbed microvasculature and warrant closer control of cardiovascular risk factors and allograft monitoring of affected patients. Clinical trial details Not applicable, the study is not a clinical trial.https://doi.org/10.1186/s12882-025-03989-5Kidney transplantationLymphoceleAllograft functioneGFR slope |
| spellingShingle | Christian Kuhn Bernd Jänigen Laura Matuschik Max J. Rieger Daniel Sidler Stefan Zschiedrich The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function BMC Nephrology Kidney transplantation Lymphocele Allograft function eGFR slope |
| title | The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function |
| title_full | The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function |
| title_fullStr | The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function |
| title_full_unstemmed | The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function |
| title_short | The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function |
| title_sort | effects of lymphocele formation after living donor kidney transplantation on mid term allograft function |
| topic | Kidney transplantation Lymphocele Allograft function eGFR slope |
| url | https://doi.org/10.1186/s12882-025-03989-5 |
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