Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma
Abstract Purpose Induction chemotherapy (IC) for patients with locally advanced stage Head and Neck Squamous Cell Carcinomas (HNSCC) before radio-chemotherapy (RCT) or surgery remains a potential treatment option. This study analyzed how the response to IC correlates with survival outcomes. Methods...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-024-06044-2 |
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| author | Francesca Huwyler Roland Giger Ruben Bill Daniel Rauch Simon Haefliger |
| author_facet | Francesca Huwyler Roland Giger Ruben Bill Daniel Rauch Simon Haefliger |
| author_sort | Francesca Huwyler |
| collection | DOAJ |
| description | Abstract Purpose Induction chemotherapy (IC) for patients with locally advanced stage Head and Neck Squamous Cell Carcinomas (HNSCC) before radio-chemotherapy (RCT) or surgery remains a potential treatment option. This study analyzed how the response to IC correlates with survival outcomes. Methods We conducted a retrospective single-center study at a tertiary cancer center. Tumors were categorized by anatomical site and response to IC (non-responders vs. responders). Data were analyzed using Kaplan-Meier survival curves and Cox regression analysis. Results A total of 48 patients received IC. Of these, 33 patients were radiologically evaluable for response. The majority of evaluable patients received either TPF (Docetaxel, Cisplatin, 5-Fluorouracil) (58%) or TP (Docetaxel, Cisplatin) (24%) as their IC regimen. Tumor reduction of 30% or more was observed in 23 patients (69.7%), the tumor control rate was 97%. The 2-year event-free survival (EFS) in the IC evaluable population was 53.1%, overall survival (OS) was 63.6%, and recurrence-free survival (RFS) was 62.5%. Patients with laryngeal or hypopharyngeal tumors that did not respond to IC had a significantly poorer prognosis. This effect was not statistically significant in tumors of the oral cavity or oropharynx, where it was only observed as a trend. Conclusion IC is highly effective in treating locally advanced stage HNSCC. The response to IC is prognostic for survival, particularly in cancers of the larynx and hypopharynx. |
| format | Article |
| id | doaj-art-6f4c12cbef3449b7babd837d3073c43f |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-6f4c12cbef3449b7babd837d3073c43f2025-02-09T12:10:11ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352024-12-0115111810.1007/s00432-024-06044-2Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinomaFrancesca Huwyler0Roland Giger1Ruben Bill2Daniel Rauch3Simon Haefliger4Department of Medical Oncology, Inselspital, Bern University Hospital, University of BernDepartment of Otorhinolaryngology, Head and Neck Surgery, Bern University Hospital, Inselspital, University of BernDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of BernDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of BernDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of BernAbstract Purpose Induction chemotherapy (IC) for patients with locally advanced stage Head and Neck Squamous Cell Carcinomas (HNSCC) before radio-chemotherapy (RCT) or surgery remains a potential treatment option. This study analyzed how the response to IC correlates with survival outcomes. Methods We conducted a retrospective single-center study at a tertiary cancer center. Tumors were categorized by anatomical site and response to IC (non-responders vs. responders). Data were analyzed using Kaplan-Meier survival curves and Cox regression analysis. Results A total of 48 patients received IC. Of these, 33 patients were radiologically evaluable for response. The majority of evaluable patients received either TPF (Docetaxel, Cisplatin, 5-Fluorouracil) (58%) or TP (Docetaxel, Cisplatin) (24%) as their IC regimen. Tumor reduction of 30% or more was observed in 23 patients (69.7%), the tumor control rate was 97%. The 2-year event-free survival (EFS) in the IC evaluable population was 53.1%, overall survival (OS) was 63.6%, and recurrence-free survival (RFS) was 62.5%. Patients with laryngeal or hypopharyngeal tumors that did not respond to IC had a significantly poorer prognosis. This effect was not statistically significant in tumors of the oral cavity or oropharynx, where it was only observed as a trend. Conclusion IC is highly effective in treating locally advanced stage HNSCC. The response to IC is prognostic for survival, particularly in cancers of the larynx and hypopharynx.https://doi.org/10.1007/s00432-024-06044-2Induction chemotherapyHead and neck squamous cell carcinomaChemotherapy responseSurvival Prediction |
| spellingShingle | Francesca Huwyler Roland Giger Ruben Bill Daniel Rauch Simon Haefliger Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma Journal of Cancer Research and Clinical Oncology Induction chemotherapy Head and neck squamous cell carcinoma Chemotherapy response Survival Prediction |
| title | Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma |
| title_full | Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma |
| title_fullStr | Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma |
| title_full_unstemmed | Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma |
| title_short | Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma |
| title_sort | response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma |
| topic | Induction chemotherapy Head and neck squamous cell carcinoma Chemotherapy response Survival Prediction |
| url | https://doi.org/10.1007/s00432-024-06044-2 |
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