Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment
The underlying neuropathological mechanisms in Binswanger’s disease (BD) with mild cognitive impairment (BD-MCI) remain unclear. The multiparameter functional magnetic resonance imaging (fMRI) including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuation...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1522591/full |
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| author | Haiyi Zhang Lu Zhang Juan Lu Jiajun Yue Zhengzhen Yuan Jidan Hu Qi Yao Yuting Fu Guiquan Chen Jiliang Fang Jie Zhao |
| author_facet | Haiyi Zhang Lu Zhang Juan Lu Jiajun Yue Zhengzhen Yuan Jidan Hu Qi Yao Yuting Fu Guiquan Chen Jiliang Fang Jie Zhao |
| author_sort | Haiyi Zhang |
| collection | DOAJ |
| description | The underlying neuropathological mechanisms in Binswanger’s disease (BD) with mild cognitive impairment (BD-MCI) remain unclear. The multiparameter functional magnetic resonance imaging (fMRI) including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), independent component analysis (ICA), and edge-link analysis was utilized to explore the abnormal brain networks of BD-MCI patients. Compared with the BD without MCI group, this study revealed that the ALFF values in the BD-MCI group were significantly increased in the Temporal_Inf_R, Frontal_Mid_Orb_L, and Hippocampus_L, while decreased in the SupraMarginal_R and Precuneus_R. The fALFF value in the BD-MCI group exhibited a reduction in the Frontal_Med_Orb_L. Additionally, ReHo values in the BD-MCI group increased in the Hippocampus_R but decreased in several areas including Precentral_L, Putamen_L, Postcentral_R, Supp_Motor_Area_R, and SupraMarginal_L. The results of ICA revealed that patients diagnosed with BD-MCI exhibited abnormal connectivity patterns across 12 groups of independent components and 5 distinct groups of brain networks. In one group, the internal connectivity within the brain network exhibited abnormalities. The correlation analysis between ALFF and ReHo values and clinical scales revealed a significant negative correlation between the bilateral hippocampus and Mini-Mental State Examination (MMSE) scores. Conversely, ReHo values for Postcentral_R and SupraMarginal_L were significantly positively correlated with MMSE scores. In summary, the results of our study suggest that patients diagnosed with BD-MCI display atypical activity across several brain regions. The observed changes in these areas encompass a range of functional networks. The reduced coordination among these functional networks may play a role in the deterioration of cognitive functions and decision-making capabilities, potentially serving as a critical mechanism contributing to the early manifestation of cognitive impairments. |
| format | Article |
| id | doaj-art-6ff0260902604b9eafb90a5a428907ff |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-6ff0260902604b9eafb90a5a428907ff2025-02-10T06:48:33ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.15225911522591Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairmentHaiyi Zhang0Lu Zhang1Juan Lu2Jiajun Yue3Zhengzhen Yuan4Jidan Hu5Qi Yao6Yuting Fu7Guiquan Chen8Jiliang Fang9Jie Zhao10Department of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Acupuncture and Rehabilitation, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Physical Education, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Radiology, The Second People’s Hospital of Neijiang, Southwest Medical University, Neijiang, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Acupuncture and Rehabilitation, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaThe underlying neuropathological mechanisms in Binswanger’s disease (BD) with mild cognitive impairment (BD-MCI) remain unclear. The multiparameter functional magnetic resonance imaging (fMRI) including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), independent component analysis (ICA), and edge-link analysis was utilized to explore the abnormal brain networks of BD-MCI patients. Compared with the BD without MCI group, this study revealed that the ALFF values in the BD-MCI group were significantly increased in the Temporal_Inf_R, Frontal_Mid_Orb_L, and Hippocampus_L, while decreased in the SupraMarginal_R and Precuneus_R. The fALFF value in the BD-MCI group exhibited a reduction in the Frontal_Med_Orb_L. Additionally, ReHo values in the BD-MCI group increased in the Hippocampus_R but decreased in several areas including Precentral_L, Putamen_L, Postcentral_R, Supp_Motor_Area_R, and SupraMarginal_L. The results of ICA revealed that patients diagnosed with BD-MCI exhibited abnormal connectivity patterns across 12 groups of independent components and 5 distinct groups of brain networks. In one group, the internal connectivity within the brain network exhibited abnormalities. The correlation analysis between ALFF and ReHo values and clinical scales revealed a significant negative correlation between the bilateral hippocampus and Mini-Mental State Examination (MMSE) scores. Conversely, ReHo values for Postcentral_R and SupraMarginal_L were significantly positively correlated with MMSE scores. In summary, the results of our study suggest that patients diagnosed with BD-MCI display atypical activity across several brain regions. The observed changes in these areas encompass a range of functional networks. The reduced coordination among these functional networks may play a role in the deterioration of cognitive functions and decision-making capabilities, potentially serving as a critical mechanism contributing to the early manifestation of cognitive impairments.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1522591/fullBinswanger’s diseasemild cognitive impairmentmultiparameterfunctional magnetic resonance imagingneuropsychological changes |
| spellingShingle | Haiyi Zhang Lu Zhang Juan Lu Jiajun Yue Zhengzhen Yuan Jidan Hu Qi Yao Yuting Fu Guiquan Chen Jiliang Fang Jie Zhao Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment Frontiers in Aging Neuroscience Binswanger’s disease mild cognitive impairment multiparameter functional magnetic resonance imaging neuropsychological changes |
| title | Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment |
| title_full | Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment |
| title_fullStr | Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment |
| title_full_unstemmed | Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment |
| title_short | Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment |
| title_sort | multiparameter resting state functional magnetic resonance imaging as an indicator of neuropsychological changes in binswanger s disease with mild cognitive impairment |
| topic | Binswanger’s disease mild cognitive impairment multiparameter functional magnetic resonance imaging neuropsychological changes |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1522591/full |
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