Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study
BackgroundMajor surgery is associated with significant morbidity and a reduced quality of life, particularly among older adults and individuals with frailty and impaired functional capacity. Multimodal prehabilitation can enhance functional recovery after surgery and reduce p...
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JMIR Publications
2025-02-01
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| Series: | JMIR mHealth and uHealth |
| Online Access: | https://mhealth.jmir.org/2025/1/e55298 |
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| author | Sara Fatima Faqar Uz Zaman Svenja Sliwinski Lisa Mohr-Wetzel Julia Dreilich Natalie Filmann Charlotte Detemble Dora Zmuc Felix Chun Wojciech Derwich Waldemar Schreiner Wolf Bechstein Johannes Fleckenstein Andreas A Schnitzbauer |
| author_facet | Sara Fatima Faqar Uz Zaman Svenja Sliwinski Lisa Mohr-Wetzel Julia Dreilich Natalie Filmann Charlotte Detemble Dora Zmuc Felix Chun Wojciech Derwich Waldemar Schreiner Wolf Bechstein Johannes Fleckenstein Andreas A Schnitzbauer |
| author_sort | Sara Fatima Faqar Uz Zaman |
| collection | DOAJ |
| description |
BackgroundMajor surgery is associated with significant morbidity and a reduced quality of life, particularly among older adults and individuals with frailty and impaired functional capacity. Multimodal prehabilitation can enhance functional recovery after surgery and reduce postoperative complications. Digital prehabilitation has the potential to be a resource-sparing and patient-empowering tool that improves patients’ preoperative status; however, little remains known regarding their safety and accuracy as medical devices.
ObjectiveThis study aims to test the accuracy and validity of a new software in comparison to the gold-standard electrocardiogram (ECG)-based heart rate measurement.
MethodsThe PROTEGO MAXIMA trial was a prospective interventional pilot trial assessing the validity, accuracy, and safety of an app-based exercise program. The Prehab App calculates a personalized, risk-stratified aerobic interval training plan based on individual risk factors and utilizes wearables to monitor heart rate. Healthy students and patients undergoing major surgery were enrolled. A structured risk assessment was conducted, followed by a 6-minute walking test and a 37-minute supervised interval session. During the exercise, patients wore app-linked wearables for heart rate and distance measurements, which were compared with standard ECG and treadmill measurements. Safety, accuracy, and usability assessments included testing alarm signals, while the occurrence of adverse events served as the primary and secondary outcome measures.
ResultsA total of 75 participants were included. The mean heart rate differences between wearables and standard ECG were ≤5 bpm (beats per minute) with a mean absolute percentage error of ≤5%. Regression analysis revealed a significant impact of the BMI (odds ratio 0.90, 95% CI 0.82-0.98, P=.02) and Timed Up and Go Test score (odds ratio 0.12, 95% CI 0.03-0.55, P=.006) on the accuracy of heart rate measurement; 29 (39%) patients experienced adverse events: pain (5/12, 42%), ECG electrode–related skin irritations (2/42, 17%), dizziness (2/42, 17%), shortness of breath (2/42, 17%), and fatigue (1/42, 8%). No cardiovascular or serious adverse events were reported, and no serious device deficiency was detected. There were no indications of clinically meaningful overexertion based on laboratory values measured before and after the 6-minute walking test and exercise. The differences in means and ranges were as follows: lactate (mmol/l), mean 0.04 (range –3 to 6; P=.47); creatinine kinase (U/l), mean 12 (range –7 to 43; P<.001); and sodium (mmol/l), mean –2 (range –11 to 12; P<.001).
ConclusionsThe interventional trial demonstrated the high safety of the exercise program and the accuracy of heart rate measurements using commercial wearables in patients before major surgery, paving the way for potential remote implementation in the future.
Trial RegistrationGerman Clinical Trials Register DRKS00026985; https://drks.de/search/en/trial/DRKS00026985 and European Database on Medical Devices (EUDAMED) CIV-21-07-0307311.
International Registered Report Identifier (IRRID)RR2-10.1136/bmjopen-2022-069394 |
| format | Article |
| id | doaj-art-6fff4a3b39d846b6a3c634d1a5a3cc93 |
| institution | Kabale University |
| issn | 2291-5222 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR mHealth and uHealth |
| spelling | doaj-art-6fff4a3b39d846b6a3c634d1a5a3cc932025-02-10T21:00:38ZengJMIR PublicationsJMIR mHealth and uHealth2291-52222025-02-0113e5529810.2196/55298Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot StudySara Fatima Faqar Uz Zamanhttps://orcid.org/0000-0002-9017-1641Svenja Sliwinskihttps://orcid.org/0000-0002-0132-618XLisa Mohr-Wetzelhttps://orcid.org/0000-0003-0916-6448Julia Dreilichhttps://orcid.org/0009-0000-9964-8314Natalie Filmannhttps://orcid.org/0000-0003-0424-2317Charlotte Detemblehttps://orcid.org/0009-0008-5523-9808Dora Zmuchttps://orcid.org/0009-0002-4584-2132Felix Chunhttps://orcid.org/0000-0001-8486-9536Wojciech Derwichhttps://orcid.org/0000-0002-4845-4728Waldemar Schreinerhttps://orcid.org/0000-0002-5866-7161Wolf Bechsteinhttps://orcid.org/0000-0002-3267-8145Johannes Fleckensteinhttps://orcid.org/0000-0003-3442-0380Andreas A Schnitzbauerhttps://orcid.org/0000-0003-1527-1877 BackgroundMajor surgery is associated with significant morbidity and a reduced quality of life, particularly among older adults and individuals with frailty and impaired functional capacity. Multimodal prehabilitation can enhance functional recovery after surgery and reduce postoperative complications. Digital prehabilitation has the potential to be a resource-sparing and patient-empowering tool that improves patients’ preoperative status; however, little remains known regarding their safety and accuracy as medical devices. ObjectiveThis study aims to test the accuracy and validity of a new software in comparison to the gold-standard electrocardiogram (ECG)-based heart rate measurement. MethodsThe PROTEGO MAXIMA trial was a prospective interventional pilot trial assessing the validity, accuracy, and safety of an app-based exercise program. The Prehab App calculates a personalized, risk-stratified aerobic interval training plan based on individual risk factors and utilizes wearables to monitor heart rate. Healthy students and patients undergoing major surgery were enrolled. A structured risk assessment was conducted, followed by a 6-minute walking test and a 37-minute supervised interval session. During the exercise, patients wore app-linked wearables for heart rate and distance measurements, which were compared with standard ECG and treadmill measurements. Safety, accuracy, and usability assessments included testing alarm signals, while the occurrence of adverse events served as the primary and secondary outcome measures. ResultsA total of 75 participants were included. The mean heart rate differences between wearables and standard ECG were ≤5 bpm (beats per minute) with a mean absolute percentage error of ≤5%. Regression analysis revealed a significant impact of the BMI (odds ratio 0.90, 95% CI 0.82-0.98, P=.02) and Timed Up and Go Test score (odds ratio 0.12, 95% CI 0.03-0.55, P=.006) on the accuracy of heart rate measurement; 29 (39%) patients experienced adverse events: pain (5/12, 42%), ECG electrode–related skin irritations (2/42, 17%), dizziness (2/42, 17%), shortness of breath (2/42, 17%), and fatigue (1/42, 8%). No cardiovascular or serious adverse events were reported, and no serious device deficiency was detected. There were no indications of clinically meaningful overexertion based on laboratory values measured before and after the 6-minute walking test and exercise. The differences in means and ranges were as follows: lactate (mmol/l), mean 0.04 (range –3 to 6; P=.47); creatinine kinase (U/l), mean 12 (range –7 to 43; P<.001); and sodium (mmol/l), mean –2 (range –11 to 12; P<.001). ConclusionsThe interventional trial demonstrated the high safety of the exercise program and the accuracy of heart rate measurements using commercial wearables in patients before major surgery, paving the way for potential remote implementation in the future. Trial RegistrationGerman Clinical Trials Register DRKS00026985; https://drks.de/search/en/trial/DRKS00026985 and European Database on Medical Devices (EUDAMED) CIV-21-07-0307311. International Registered Report Identifier (IRRID)RR2-10.1136/bmjopen-2022-069394https://mhealth.jmir.org/2025/1/e55298 |
| spellingShingle | Sara Fatima Faqar Uz Zaman Svenja Sliwinski Lisa Mohr-Wetzel Julia Dreilich Natalie Filmann Charlotte Detemble Dora Zmuc Felix Chun Wojciech Derwich Waldemar Schreiner Wolf Bechstein Johannes Fleckenstein Andreas A Schnitzbauer Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study JMIR mHealth and uHealth |
| title | Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study |
| title_full | Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study |
| title_fullStr | Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study |
| title_full_unstemmed | Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study |
| title_short | Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Interventional Pilot Study |
| title_sort | validity accuracy and safety assessment of an aerobic interval training using an app based prehabilitation program protego maxima trial before major surgery prospective interventional pilot study |
| url | https://mhealth.jmir.org/2025/1/e55298 |
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