The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy
OBJECTIVE: To evaluate the pregnancy outcome of women with nausea and vomiting of pregnancy (NVP) who were treated with either ondansetron or chlorpromazine. STUDY DESIGN: This retrospective study included 185 women who were hospitalized in the first trimester for treatment of NVP and treated with...
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| Format: | Article |
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Medical Network
2014-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/140 |
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| author | Şafak Özdemirci Funda Akpınar Melek Bilge Funda Özdemirci Saynur Yılmaz Deniz Esinler İnci Kahyaoğlu |
| author_facet | Şafak Özdemirci Funda Akpınar Melek Bilge Funda Özdemirci Saynur Yılmaz Deniz Esinler İnci Kahyaoğlu |
| author_sort | Şafak Özdemirci |
| collection | DOAJ |
| description |
OBJECTIVE: To evaluate the pregnancy outcome of women with nausea and vomiting of pregnancy (NVP) who were treated with either ondansetron or chlorpromazine.
STUDY DESIGN: This retrospective study included 185 women who were hospitalized in the first trimester for treatment of NVP and treated with either ondansetron or chlorpromazine between January 2006 and March 2011 at Simav Government Hospital. We evaluated the pregnancy outcome including birth weight, pregnancy induced hypertension, preterm birth and major congenital malformations.
RESULTS: In the ondansetron group 4 (4%) low birth weight newborn, 9 (9%) preterm birth and 1 (1%) congenital anomaly, while in chlorpromazine group 1 (1.2%) low birth weight newborn, 9 (10.6%) preterm birth and 4 (4.7%) congenital anomalies were observed.
CONCLUSION: The malformation risk for both drugs found to be similar to baseline. Although the sample size was small, both drugs found to be safe to use in first trimester for NVP.
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| format | Article |
| id | doaj-art-700338129c444edfb8a3adb1ea0284e2 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-700338129c444edfb8a3adb1ea0284e22025-02-11T21:23:50ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182014-08-0120282The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester PregnancyŞafak Özdemirci0Funda Akpınar1Melek Bilge2Funda Özdemirci3Saynur Yılmaz4Deniz Esinler5İnci Kahyaoğlu6Simav Government Hospital, KütahyaEtlik Zübeyde Hanım Gynecology Education and Research Hospital, AnkaraDr Faruk Sükan Women Health and Child Hospital KonyaBaşkent University, Ankara Başkent Hospital Family Medicine Department, AnkaraEtlik Zübeyde Hanım Gynecology Education and Research Hospital, AnkaraEtlik Zübeyde Hanım Gynecology Education and Research Hospital, AnkaraEtlik Zübeyde Hanım Gynecology Education and Research Hospital, Ankara OBJECTIVE: To evaluate the pregnancy outcome of women with nausea and vomiting of pregnancy (NVP) who were treated with either ondansetron or chlorpromazine. STUDY DESIGN: This retrospective study included 185 women who were hospitalized in the first trimester for treatment of NVP and treated with either ondansetron or chlorpromazine between January 2006 and March 2011 at Simav Government Hospital. We evaluated the pregnancy outcome including birth weight, pregnancy induced hypertension, preterm birth and major congenital malformations. RESULTS: In the ondansetron group 4 (4%) low birth weight newborn, 9 (9%) preterm birth and 1 (1%) congenital anomaly, while in chlorpromazine group 1 (1.2%) low birth weight newborn, 9 (10.6%) preterm birth and 4 (4.7%) congenital anomalies were observed. CONCLUSION: The malformation risk for both drugs found to be similar to baseline. Although the sample size was small, both drugs found to be safe to use in first trimester for NVP. https://gorm.com.tr/index.php/GORM/article/view/140Nausea and vomiting of pregnancy (NVP)OndansetronChlorpromazineFirst trimester pregnancy |
| spellingShingle | Şafak Özdemirci Funda Akpınar Melek Bilge Funda Özdemirci Saynur Yılmaz Deniz Esinler İnci Kahyaoğlu The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy Gynecology Obstetrics & Reproductive Medicine Nausea and vomiting of pregnancy (NVP) Ondansetron Chlorpromazine First trimester pregnancy |
| title | The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy |
| title_full | The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy |
| title_fullStr | The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy |
| title_full_unstemmed | The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy |
| title_short | The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy |
| title_sort | safety of ondansetron and chlorpromazine for hyperemesis gravidarum in first trimester pregnancy |
| topic | Nausea and vomiting of pregnancy (NVP) Ondansetron Chlorpromazine First trimester pregnancy |
| url | https://gorm.com.tr/index.php/GORM/article/view/140 |
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