Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats
Background: Alcohol consumption has a negative effect on male fertility, but Vitamin C may be able to alleviate this effect. Aims: In this study, the protective effect of Vitamin C against alcohol-induced testicular damage in adult male Wistar rats was evaluated. Settings and Design: This study was...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jhrs.jhrs_39_23 |
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| author | Taiwo Emmanuel George Peter Okhemukhokho Okhiai Ifabunmi Oduyemi Osonuga Olusoji Adebusoye Oyesola |
| author_facet | Taiwo Emmanuel George Peter Okhemukhokho Okhiai Ifabunmi Oduyemi Osonuga Olusoji Adebusoye Oyesola |
| author_sort | Taiwo Emmanuel George |
| collection | DOAJ |
| description | Background:
Alcohol consumption has a negative effect on male fertility, but Vitamin C may be able to alleviate this effect.
Aims:
In this study, the protective effect of Vitamin C against alcohol-induced testicular damage in adult male Wistar rats was evaluated.
Settings and Design:
This study was conducted in a University setting. Following a 14-day acclimatisation period, forty adult male Wistar rats were randomly divided into eight groups of five rats. The control group received only food and water, test group B received alcohol only, test group C to E received different doses of Vitamin C, test group F to G received different doses of Vitamin C and alcohol.
Materials and Methods:
After a 21-day treatment period, the testis were harvested and analysed for sperm parameters, antioxidant enzyme activity, level of lipid peroxidation and histopathological changes.
Statistical Analysis Used:
All analyses was performed using SPSS (version 16) and Microsoft Excel (2019) using Student's t-test.
Results:
The results showed that in groups administered with alcohol only, there was a decrease in sperm count. Sperm motility, morphology, viability and antioxidant enzyme activity, but increase in the level of lipid peroxidation. In groups treated with Vitamin C and alcohol, there was improvement in the sperm parameters, antioxidant enzymes activity and a decrease and decrease in lipid peroxidation. Furthermore, in the histology of the testis, regenerative changes were seen.
Conclusion:
The chronic consumption of alcohol can have a deleterious effect on the testis, but commercial-grade Vitamin C can reverse these effects. |
| format | Article |
| id | doaj-art-70516dbeff1940afb45e4ffcfb7c4fef |
| institution | Kabale University |
| issn | 0974-1208 1998-4766 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj-art-70516dbeff1940afb45e4ffcfb7c4fef2025-02-10T07:43:06ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662023-04-011629910510.4103/jhrs.jhrs_39_23Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar RatsTaiwo Emmanuel GeorgePeter Okhemukhokho OkhiaiIfabunmi Oduyemi OsonugaOlusoji Adebusoye OyesolaBackground: Alcohol consumption has a negative effect on male fertility, but Vitamin C may be able to alleviate this effect. Aims: In this study, the protective effect of Vitamin C against alcohol-induced testicular damage in adult male Wistar rats was evaluated. Settings and Design: This study was conducted in a University setting. Following a 14-day acclimatisation period, forty adult male Wistar rats were randomly divided into eight groups of five rats. The control group received only food and water, test group B received alcohol only, test group C to E received different doses of Vitamin C, test group F to G received different doses of Vitamin C and alcohol. Materials and Methods: After a 21-day treatment period, the testis were harvested and analysed for sperm parameters, antioxidant enzyme activity, level of lipid peroxidation and histopathological changes. Statistical Analysis Used: All analyses was performed using SPSS (version 16) and Microsoft Excel (2019) using Student's t-test. Results: The results showed that in groups administered with alcohol only, there was a decrease in sperm count. Sperm motility, morphology, viability and antioxidant enzyme activity, but increase in the level of lipid peroxidation. In groups treated with Vitamin C and alcohol, there was improvement in the sperm parameters, antioxidant enzymes activity and a decrease and decrease in lipid peroxidation. Furthermore, in the histology of the testis, regenerative changes were seen. Conclusion: The chronic consumption of alcohol can have a deleterious effect on the testis, but commercial-grade Vitamin C can reverse these effects.https://journals.lww.com/10.4103/jhrs.jhrs_39_23alcoholantioxidantlipid peroxidationmale fertilityvitamin c |
| spellingShingle | Taiwo Emmanuel George Peter Okhemukhokho Okhiai Ifabunmi Oduyemi Osonuga Olusoji Adebusoye Oyesola Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats Journal of Human Reproductive Sciences alcohol antioxidant lipid peroxidation male fertility vitamin c |
| title | Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats |
| title_full | Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats |
| title_fullStr | Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats |
| title_full_unstemmed | Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats |
| title_short | Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats |
| title_sort | protective effect of commercial grade vitamin c against alcohol induced testicular damage in male wistar rats |
| topic | alcohol antioxidant lipid peroxidation male fertility vitamin c |
| url | https://journals.lww.com/10.4103/jhrs.jhrs_39_23 |
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