HIV and the gut microbiome: future research hotspots and trends
BackgroundThe use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. Modulating the gut microbiome of patients may improve this situation, yet the specific association mechanisms bet...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1466419/full |
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| author | Zhen Wu Zhan-Peng Xie Xin-Xin Cui Xiang-Bin Sun Fang-Yi Zhao Nuo Wang Yu Li Yu Li Yu Li Haixia Wang Haixia Wang Haixia Wang Li Zhang Li Zhang Li Zhang Jing Shen Fulei Chen Haogang Sun Jia He Jia He Jia He |
| author_facet | Zhen Wu Zhan-Peng Xie Xin-Xin Cui Xiang-Bin Sun Fang-Yi Zhao Nuo Wang Yu Li Yu Li Yu Li Haixia Wang Haixia Wang Haixia Wang Li Zhang Li Zhang Li Zhang Jing Shen Fulei Chen Haogang Sun Jia He Jia He Jia He |
| author_sort | Zhen Wu |
| collection | DOAJ |
| description | BackgroundThe use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. Modulating the gut microbiome of patients may improve this situation, yet the specific association mechanisms between HIV and the gut microbiome remain unclear. This study aims to explore the research hotspots and trends of the HIV and the gut microbiome, providing direction for future research.MethodsWe conducted a search of the Web of Science Core Collection database up to April 30, 2024 to retrieve articles related to the relationship between the HIV and the gut microbiome. The scientific achievements and research frontiers in this field were analyzed using CiteSpace, VOSviewer, and Bibliometrix statistical software.ResultsAs of April 30, 2024, a total of 379 articles met the inclusion criteria. The number of publications in this field peaked in 2023, and the number of articles published after 2020 declined. The country with the highest number of publications was the United States (184 articles), and the institution with the most publications was the University of Colorado (USA) (21 articles). The author with the most publications was Routy Jean-Pierre (Canada) (14 articles). High-frequency keywords, aside from the key terms, included “HIV,” “inflammation,” “immune activation,” “gut microbiota,” and “translocation.” Keyword burst results indicated that short-chain fatty acids, T cells and obesity might become the focus of future research.ConclusionThe research hotspots in this field should prioritize examining the role of the primary gut microbiome metabolite, short-chain fatty acids, in reducing immune system activation and inflammation. Another emerging area of interest could be the investigation into the annual increase in obesity rates within this field. Furthermore, understanding the metabolic mechanisms of short-chain fatty acids in T cells is essential. Additionally, multi-omics analysis holds potential. |
| format | Article |
| id | doaj-art-705cde04ce064c408fa9e350cb7902a0 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-705cde04ce064c408fa9e350cb7902a02025-02-07T17:14:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.14664191466419HIV and the gut microbiome: future research hotspots and trendsZhen Wu0Zhan-Peng Xie1Xin-Xin Cui2Xiang-Bin Sun3Fang-Yi Zhao4Nuo Wang5Yu Li6Yu Li7Yu Li8Haixia Wang9Haixia Wang10Haixia Wang11Li Zhang12Li Zhang13Li Zhang14Jing Shen15Fulei Chen16Haogang Sun17Jia He18Jia He19Jia He20Medical School of Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaDepartment of Preventive Medicine, Medical School of Shihezi University, Shihezi, ChinaKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, The Xinjiang Production and Construction Corps, Ürümqi, ChinaMedical School of Shihezi University, Shihezi, ChinaDepartment of Preventive Medicine, Medical School of Shihezi University, Shihezi, ChinaKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, The Xinjiang Production and Construction Corps, Ürümqi, ChinaMedical School of Shihezi University, Shihezi, ChinaDepartment of Preventive Medicine, Medical School of Shihezi University, Shihezi, ChinaKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, The Xinjiang Production and Construction Corps, Ürümqi, ChinaSchool of Medicine, First Affiliated Hospital, Shihezi University, Shihezi, ChinaSchool of Medicine, First Affiliated Hospital, Shihezi University, Shihezi, ChinaSchool of Medicine, First Affiliated Hospital, Shihezi University, Shihezi, ChinaMedical School of Shihezi University, Shihezi, ChinaDepartment of Preventive Medicine, Medical School of Shihezi University, Shihezi, ChinaKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, The Xinjiang Production and Construction Corps, Ürümqi, ChinaBackgroundThe use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. Modulating the gut microbiome of patients may improve this situation, yet the specific association mechanisms between HIV and the gut microbiome remain unclear. This study aims to explore the research hotspots and trends of the HIV and the gut microbiome, providing direction for future research.MethodsWe conducted a search of the Web of Science Core Collection database up to April 30, 2024 to retrieve articles related to the relationship between the HIV and the gut microbiome. The scientific achievements and research frontiers in this field were analyzed using CiteSpace, VOSviewer, and Bibliometrix statistical software.ResultsAs of April 30, 2024, a total of 379 articles met the inclusion criteria. The number of publications in this field peaked in 2023, and the number of articles published after 2020 declined. The country with the highest number of publications was the United States (184 articles), and the institution with the most publications was the University of Colorado (USA) (21 articles). The author with the most publications was Routy Jean-Pierre (Canada) (14 articles). High-frequency keywords, aside from the key terms, included “HIV,” “inflammation,” “immune activation,” “gut microbiota,” and “translocation.” Keyword burst results indicated that short-chain fatty acids, T cells and obesity might become the focus of future research.ConclusionThe research hotspots in this field should prioritize examining the role of the primary gut microbiome metabolite, short-chain fatty acids, in reducing immune system activation and inflammation. Another emerging area of interest could be the investigation into the annual increase in obesity rates within this field. Furthermore, understanding the metabolic mechanisms of short-chain fatty acids in T cells is essential. Additionally, multi-omics analysis holds potential.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1466419/fullHIV/AIDSgut microbiomebibliometricsshort-chain fatty acidsT cellsobesity |
| spellingShingle | Zhen Wu Zhan-Peng Xie Xin-Xin Cui Xiang-Bin Sun Fang-Yi Zhao Nuo Wang Yu Li Yu Li Yu Li Haixia Wang Haixia Wang Haixia Wang Li Zhang Li Zhang Li Zhang Jing Shen Fulei Chen Haogang Sun Jia He Jia He Jia He HIV and the gut microbiome: future research hotspots and trends Frontiers in Microbiology HIV/AIDS gut microbiome bibliometrics short-chain fatty acids T cells obesity |
| title | HIV and the gut microbiome: future research hotspots and trends |
| title_full | HIV and the gut microbiome: future research hotspots and trends |
| title_fullStr | HIV and the gut microbiome: future research hotspots and trends |
| title_full_unstemmed | HIV and the gut microbiome: future research hotspots and trends |
| title_short | HIV and the gut microbiome: future research hotspots and trends |
| title_sort | hiv and the gut microbiome future research hotspots and trends |
| topic | HIV/AIDS gut microbiome bibliometrics short-chain fatty acids T cells obesity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1466419/full |
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