Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells
Exposure to airborne particulate matter (PM) is a major risk which increases pulmonary diseases such as asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD). PM is a complex mixture with physiochemical properties that can vary over time and space, presenting a challenge when a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001812 |
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| _version_ | 1823861261171949568 |
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| author | Bingxue Nie Daoqiang Zhang Xin Liu Chengying Lei Zhiruo Li Nan Zhang Shuping Zhang Yiju Wei Jie Zhang |
| author_facet | Bingxue Nie Daoqiang Zhang Xin Liu Chengying Lei Zhiruo Li Nan Zhang Shuping Zhang Yiju Wei Jie Zhang |
| author_sort | Bingxue Nie |
| collection | DOAJ |
| description | Exposure to airborne particulate matter (PM) is a major risk which increases pulmonary diseases such as asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD). PM is a complex mixture with physiochemical properties that can vary over time and space, presenting a challenge when attempting to analyze their health risks. In this study, we compared two kinds of commercial PM with real PM to explore an index which takes account of both the diverse physicochemical properties of PM and accurate prediction of their toxicities. Our results indicated that the oxidative potential (OP) of PM significantly affects their cytotoxicity. In comparison to two kinds of commercial PM such as carbon black and SRM-1648a, real ambient PM2.5 induced more significant oxidative stress and ferroptosis, which was closely associated with its higher OP. Notably, the use of radical scavengers like vitamin C and coumarin decreased the OP of PM2.5 effectively, thereby leading to a decrease in its cytotoxic effects. Furthermore, the reduction of OP reversed redox imbalance and alleviated lung damage in vivo. This study provides additional insights into the structure-activity relationship for PM’s toxicity. It also sheds light on further investigations on the detoxication of PM. |
| format | Article |
| id | doaj-art-71813dfa890f4dafa2d66df58ea2e3c0 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-71813dfa890f4dafa2d66df58ea2e3c02025-02-10T04:33:28ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117845Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cellsBingxue Nie0Daoqiang Zhang1Xin Liu2Chengying Lei3Zhiruo Li4Nan Zhang5Shuping Zhang6Yiju Wei7Jie Zhang8Department of Epidemiology, The First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Shengli Oilfield Central Hospital, Clinical Laboratory department, Dongying, Shandong 257000, ChinaWeihai Central Hospital, Central Laboratory, Weihai, Shandong 264400, ChinaDepartment of Epidemiology, The First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, ChinaDepartment of Epidemiology, The First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, ChinaDepartment of Epidemiology, The First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, ChinaScience and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, ChinaDepartment of Epidemiology, The First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, ChinaScience and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, ChinaDepartment of Epidemiology, The First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Corresponding author.Exposure to airborne particulate matter (PM) is a major risk which increases pulmonary diseases such as asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD). PM is a complex mixture with physiochemical properties that can vary over time and space, presenting a challenge when attempting to analyze their health risks. In this study, we compared two kinds of commercial PM with real PM to explore an index which takes account of both the diverse physicochemical properties of PM and accurate prediction of their toxicities. Our results indicated that the oxidative potential (OP) of PM significantly affects their cytotoxicity. In comparison to two kinds of commercial PM such as carbon black and SRM-1648a, real ambient PM2.5 induced more significant oxidative stress and ferroptosis, which was closely associated with its higher OP. Notably, the use of radical scavengers like vitamin C and coumarin decreased the OP of PM2.5 effectively, thereby leading to a decrease in its cytotoxic effects. Furthermore, the reduction of OP reversed redox imbalance and alleviated lung damage in vivo. This study provides additional insights into the structure-activity relationship for PM’s toxicity. It also sheds light on further investigations on the detoxication of PM.http://www.sciencedirect.com/science/article/pii/S0147651325001812Airborne particulate matterOxidative potentialRedox imbalanceFerroptosisDetoxication |
| spellingShingle | Bingxue Nie Daoqiang Zhang Xin Liu Chengying Lei Zhiruo Li Nan Zhang Shuping Zhang Yiju Wei Jie Zhang Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells Ecotoxicology and Environmental Safety Airborne particulate matter Oxidative potential Redox imbalance Ferroptosis Detoxication |
| title | Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells |
| title_full | Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells |
| title_fullStr | Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells |
| title_full_unstemmed | Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells |
| title_short | Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells |
| title_sort | oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells |
| topic | Airborne particulate matter Oxidative potential Redox imbalance Ferroptosis Detoxication |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001812 |
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