The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial
Background: The efficacy of different uterotonic agents is yet to be determined. Methods: This was a randomized clinical trial on 240 pregnant mothers with a history of cesarean section in three groups: A: sublingual misoprostol and oxytocin, B: intrauterine misoprostol and oxytocin, and C: a higher...
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Elsevier
2025-03-01
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| Series: | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590161325000055 |
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| author | Mahdieh Masoumzadeh Vahideh Rahmani Manizheh Sayyah-Melli Anis Sani |
| author_facet | Mahdieh Masoumzadeh Vahideh Rahmani Manizheh Sayyah-Melli Anis Sani |
| author_sort | Mahdieh Masoumzadeh |
| collection | DOAJ |
| description | Background: The efficacy of different uterotonic agents is yet to be determined. Methods: This was a randomized clinical trial on 240 pregnant mothers with a history of cesarean section in three groups: A: sublingual misoprostol and oxytocin, B: intrauterine misoprostol and oxytocin, and C: a higher dose of oxytocin alone. The intrapartum blood loss and the estimated blood loss within 24 h after surgery were compared between the groups. Results: The baseline characteristics showed no significant differences among the groups. The volume of blood loss during surgery and within 24 h postpartum did not differ significantly among the groups (A: 230.72 ± 97.30, B: 245.60 ± 88.50, C: 229.02 ± 109.78, p = 0.115, and A: 2023.84 ± 480.08, B: 2045.26 ± 598.99, C: 2025.61 ± 538.93, p = 0.819, respectively). Conclusion: Intrauterine misoprostol plus oxytocin, sublingual misoprostol plus oxytocin and a higher dose of oxytocin did not show any significant difference in the amount of blood loss during surgery and within 24 h post-operation. |
| format | Article |
| id | doaj-art-72a04a14920d407d9e06fa2ab33fd906 |
| institution | Kabale University |
| issn | 2590-1613 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
| spelling | doaj-art-72a04a14920d407d9e06fa2ab33fd9062025-02-07T04:48:15ZengElsevierEuropean Journal of Obstetrics & Gynecology and Reproductive Biology: X2590-16132025-03-0125100369The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trialMahdieh Masoumzadeh0Vahideh Rahmani1Manizheh Sayyah-Melli2Anis Sani3Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, IranWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence to: Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, P.O. Box: 5138663134, Tabriz, Iran.Fellowship of Gynecologic Oncology. Women's Reproductive Health Research Centre, Tabriz University of Medical Sciences, Tabriz, IranTabriz University of Medical Sciences, Tabriz, IranBackground: The efficacy of different uterotonic agents is yet to be determined. Methods: This was a randomized clinical trial on 240 pregnant mothers with a history of cesarean section in three groups: A: sublingual misoprostol and oxytocin, B: intrauterine misoprostol and oxytocin, and C: a higher dose of oxytocin alone. The intrapartum blood loss and the estimated blood loss within 24 h after surgery were compared between the groups. Results: The baseline characteristics showed no significant differences among the groups. The volume of blood loss during surgery and within 24 h postpartum did not differ significantly among the groups (A: 230.72 ± 97.30, B: 245.60 ± 88.50, C: 229.02 ± 109.78, p = 0.115, and A: 2023.84 ± 480.08, B: 2045.26 ± 598.99, C: 2025.61 ± 538.93, p = 0.819, respectively). Conclusion: Intrauterine misoprostol plus oxytocin, sublingual misoprostol plus oxytocin and a higher dose of oxytocin did not show any significant difference in the amount of blood loss during surgery and within 24 h post-operation.http://www.sciencedirect.com/science/article/pii/S2590161325000055MisoprostolOxytocinPostpartum hemorrhageCesarean Section |
| spellingShingle | Mahdieh Masoumzadeh Vahideh Rahmani Manizheh Sayyah-Melli Anis Sani The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial European Journal of Obstetrics & Gynecology and Reproductive Biology: X Misoprostol Oxytocin Postpartum hemorrhage Cesarean Section |
| title | The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial |
| title_full | The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial |
| title_fullStr | The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial |
| title_full_unstemmed | The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial |
| title_short | The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial |
| title_sort | effect of oxytocin sublingual and intrauterine misoprostol on blood loss in cesarean delivery a randomized clinical trial |
| topic | Misoprostol Oxytocin Postpartum hemorrhage Cesarean Section |
| url | http://www.sciencedirect.com/science/article/pii/S2590161325000055 |
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