Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India.
Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was initially thought to affect only the upper respiratory tract, can affect almost all systems....
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Indonesian Society for Biochemistry and Molecular Biology
2024-08-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/172 |
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| author | Chetna Singla Dhananjay Tiwari Himali Jha Mohammad Mustufa Khan Sadaf Parveen Roshan Alam |
| author_facet | Chetna Singla Dhananjay Tiwari Himali Jha Mohammad Mustufa Khan Sadaf Parveen Roshan Alam |
| author_sort | Chetna Singla |
| collection | DOAJ |
| description |
Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was initially thought to affect only the upper respiratory tract, can affect almost all systems. COVID-19 survivors who are critically ill featured hyper inflammation and the associated biomarkers may be useful for risk stratification.
Objective: We aimed to estimate the levels of several biomarkers, including serum C-reactive protein (CRP), D-dimer, and serum ferritin in Covid-19 survivors to reduce the further disease complication and its-associated mortality.
Method: This case-control study was conducted on COVID-19 survivors and a control group without a history of Covid-19. The D-dimer and Ferritin were determined by using Mini Vidas Immuno assay analyser and CRP was estimated Dimension RXL Siemens autoanalyzer by Particle Enhanced Turbidimetric Immunoassay.
Results: The results indicated that CRP levels were higher in COVID-19 survivors compared to controls (p<0.0001). The mean of D-dimer was found to be elevated in COVID-19 survivors as compared to controls (p<0.0001). Similarly, the ferritin level was also found to be raised in COVID-19 survivors as compared to controls (p<0.0001).
Conclusion: Results revealed that COVID-19 survivors had considerably higher mean levels of CRP, D-dimer, and ferritin than controls.
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| format | Article |
| id | doaj-art-72d61d9fff2947b6957d057c595229bf |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-72d61d9fff2947b6957d057c595229bf2025-02-08T03:04:47ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222024-08-016210.32889/actabioina.172Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India.Chetna Singla0Dhananjay Tiwari1Himali Jha2Mohammad Mustufa Khan3Sadaf Parveen4Roshan Alam5Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Prasad Institute of Medical Sciences, IndiaDepartment of Medicine, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was initially thought to affect only the upper respiratory tract, can affect almost all systems. COVID-19 survivors who are critically ill featured hyper inflammation and the associated biomarkers may be useful for risk stratification. Objective: We aimed to estimate the levels of several biomarkers, including serum C-reactive protein (CRP), D-dimer, and serum ferritin in Covid-19 survivors to reduce the further disease complication and its-associated mortality. Method: This case-control study was conducted on COVID-19 survivors and a control group without a history of Covid-19. The D-dimer and Ferritin were determined by using Mini Vidas Immuno assay analyser and CRP was estimated Dimension RXL Siemens autoanalyzer by Particle Enhanced Turbidimetric Immunoassay. Results: The results indicated that CRP levels were higher in COVID-19 survivors compared to controls (p<0.0001). The mean of D-dimer was found to be elevated in COVID-19 survivors as compared to controls (p<0.0001). Similarly, the ferritin level was also found to be raised in COVID-19 survivors as compared to controls (p<0.0001). Conclusion: Results revealed that COVID-19 survivors had considerably higher mean levels of CRP, D-dimer, and ferritin than controls. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/172C-reactive proteinD-dimersevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)serum ferritin |
| spellingShingle | Chetna Singla Dhananjay Tiwari Himali Jha Mohammad Mustufa Khan Sadaf Parveen Roshan Alam Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. Acta Biochimica Indonesiana C-reactive protein D-dimer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serum ferritin |
| title | Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. |
| title_full | Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. |
| title_fullStr | Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. |
| title_full_unstemmed | Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. |
| title_short | Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. |
| title_sort | estimation of d dimer c reactive protein and ferritin in covid 19 survivors in a north indian hospital lucknow india |
| topic | C-reactive protein D-dimer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serum ferritin |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/172 |
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