ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa
Background. ABO-incompatible kidney transplantation gives patients with chronic kidney disease requiring dialysis and without a blood group-compatible donor an alternative option for a kidney transplant. Objectives. To describe our first experiences and outcomes with 3 patients using Glycosor...
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| Language: | English |
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South African Medical Association
2024-04-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/1326 |
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| author | Z A Barday |
| author_facet | Z A Barday |
| author_sort | Z A Barday |
| collection | DOAJ |
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Background. ABO-incompatible kidney transplantation gives patients with chronic kidney disease requiring dialysis and without a blood group-compatible donor an alternative option for a kidney transplant.
Objectives. To describe our first experiences and outcomes with 3 patients using Glycosorb ABO immunoadsorption (IA) columns in performing ABO-incompatible living-donor kidney transplants. This is the first time this technique has been used in Africa.
Methods. As per the protocol, patients needed between 1 and 4 sessions of IA and received rituximab ~ one month before transplantation.
Results. All the patients achieved the target isohaemagglutinin antibody titre of 1:4 pretransplant. Only 1 patient with the highest initial screening titre (1:256) needed IA post-transplant. None of the patients experienced clinical rejection, and all had good graft kidney function at discharge and at the time of writing.
Conclusion. Glycosorb ABO IA is an effective technique in enabling ABO-incompatible living-donor kidney transplants to be performed successfully in a South African setting.
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| format | Article |
| id | doaj-art-72fb8f7153f5403fb1af43928dd71bb3 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-72fb8f7153f5403fb1af43928dd71bb32025-02-10T12:26:14ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352024-04-011143b10.7196/SAMJ.2024.v114i3b.1326ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South AfricaZ A Barday0Division of Nephrology and Hypertension, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa Background. ABO-incompatible kidney transplantation gives patients with chronic kidney disease requiring dialysis and without a blood group-compatible donor an alternative option for a kidney transplant. Objectives. To describe our first experiences and outcomes with 3 patients using Glycosorb ABO immunoadsorption (IA) columns in performing ABO-incompatible living-donor kidney transplants. This is the first time this technique has been used in Africa. Methods. As per the protocol, patients needed between 1 and 4 sessions of IA and received rituximab ~ one month before transplantation. Results. All the patients achieved the target isohaemagglutinin antibody titre of 1:4 pretransplant. Only 1 patient with the highest initial screening titre (1:256) needed IA post-transplant. None of the patients experienced clinical rejection, and all had good graft kidney function at discharge and at the time of writing. Conclusion. Glycosorb ABO IA is an effective technique in enabling ABO-incompatible living-donor kidney transplants to be performed successfully in a South African setting. https://samajournals.co.za/index.php/samj/article/view/1326ABO-incompatible |
| spellingShingle | Z A Barday ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa South African Medical Journal ABO-incompatible |
| title | ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa |
| title_full | ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa |
| title_fullStr | ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa |
| title_full_unstemmed | ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa |
| title_short | ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa |
| title_sort | abo incompatible kidney transplantation using immunoadsorption columns first experiences in south africa |
| topic | ABO-incompatible |
| url | https://samajournals.co.za/index.php/samj/article/view/1326 |
| work_keys_str_mv | AT zabarday aboincompatiblekidneytransplantationusingimmunoadsorptioncolumnsfirstexperiencesinsouthafrica |