FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION
Introduction:The Rh blood group system is one of the most polymorphic and immunogenic blood group systems in humans. The expression of its antigens is complex, among that Rh-D antigen is the most important antigen because of its high immunogenicity. Molecular genetic of RHD gene revealed that weak...
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Baqai University Press
2024-09-01
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| Series: | Baqai Journal of Health Sciences |
| Online Access: | https://journals.baqai.edu.pk/index.php/CS/article/view/65 |
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| author | Muhammad Usman et al |
| author_facet | Muhammad Usman et al |
| author_sort | Muhammad Usman et al |
| collection | DOAJ |
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Introduction:The Rh blood group system is one of the most polymorphic and immunogenic blood group
systems in humans. The expression of its antigens is complex, among that Rh-D antigen is the most
important antigen because of its high immunogenicity. Molecular genetic of RHD gene revealed that weak
D antigen is a Rh-D phenotype that possesses less numbers of D antigen epitopes on surface of red cells.
These individuals usually labeled RhD -ve by conventional testing but when transfused to RhD –ve person,
it can elicit antibody production. Variableincidence of weak D worldwide,lack of awareness, proper data
& multi-ethnic population of our country propelled to analyze it.
Material and Methods:A cross-sectional study conducted from August 2012 to August 2014. Around
48,228 healthy blood donors were tested for RhD factor. Commercially available monoclonal anti-D sera
were used to detect Rh-D factor status. Individuals found negative with saline anti-D, were further
investigated for weak D antigen by using indirect Coomb’s technique (IAT).
Results:Among 48,228 healthy blood donors, 44853 (93%) were Rh-D factor positive while 3375 (7%)
were Rh-D factor negative. Among these, 3375 Rh-D factor negative individuals 27 (0.8%) were found
to be weak D positive.
Conclusion: Although frequency of weak D does not came high among our donors but is still significant
enough to advocate testing of weak D in routine for all Rh –ve donors & pregnant women in order to avoid
consequences of anti-D allo-immunization which can lead to serious hemato-pathological problem.
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| format | Article |
| id | doaj-art-730ecaf08c6d4c56a8f5dc7f8cec8532 |
| institution | Kabale University |
| issn | 2312-4423 2312-6884 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Baqai University Press |
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| series | Baqai Journal of Health Sciences |
| spelling | doaj-art-730ecaf08c6d4c56a8f5dc7f8cec85322025-02-11T18:45:48ZengBaqai University PressBaqai Journal of Health Sciences2312-44232312-68842024-09-012301FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATIONMuhammad Usman et al Introduction:The Rh blood group system is one of the most polymorphic and immunogenic blood group systems in humans. The expression of its antigens is complex, among that Rh-D antigen is the most important antigen because of its high immunogenicity. Molecular genetic of RHD gene revealed that weak D antigen is a Rh-D phenotype that possesses less numbers of D antigen epitopes on surface of red cells. These individuals usually labeled RhD -ve by conventional testing but when transfused to RhD –ve person, it can elicit antibody production. Variableincidence of weak D worldwide,lack of awareness, proper data & multi-ethnic population of our country propelled to analyze it. Material and Methods:A cross-sectional study conducted from August 2012 to August 2014. Around 48,228 healthy blood donors were tested for RhD factor. Commercially available monoclonal anti-D sera were used to detect Rh-D factor status. Individuals found negative with saline anti-D, were further investigated for weak D antigen by using indirect Coomb’s technique (IAT). Results:Among 48,228 healthy blood donors, 44853 (93%) were Rh-D factor positive while 3375 (7%) were Rh-D factor negative. Among these, 3375 Rh-D factor negative individuals 27 (0.8%) were found to be weak D positive. Conclusion: Although frequency of weak D does not came high among our donors but is still significant enough to advocate testing of weak D in routine for all Rh –ve donors & pregnant women in order to avoid consequences of anti-D allo-immunization which can lead to serious hemato-pathological problem. https://journals.baqai.edu.pk/index.php/CS/article/view/65 |
| spellingShingle | Muhammad Usman et al FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION Baqai Journal of Health Sciences |
| title | FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION |
| title_full | FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION |
| title_fullStr | FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION |
| title_full_unstemmed | FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION |
| title_short | FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION |
| title_sort | frequency of rh d negative weak d in pakistani population |
| url | https://journals.baqai.edu.pk/index.php/CS/article/view/65 |
| work_keys_str_mv | AT muhammadusmanetal frequencyofrhdnegativeweakdinpakistanipopulation |