Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review
Background: Ascophyllum nodosum, a brown alga, is a potential natural remedy with a diverse application for disease prevention and therapeutic support. It contains a variety of biologically active phyto-compounds that show a vast array of pharmacological properties, including anti-inflammatory, anti...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001921 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861107909984256 |
|---|---|
| author | Brijesh Singh Chauhan Yash Pal Singh |
| author_facet | Brijesh Singh Chauhan Yash Pal Singh |
| author_sort | Brijesh Singh Chauhan |
| collection | DOAJ |
| description | Background: Ascophyllum nodosum, a brown alga, is a potential natural remedy with a diverse application for disease prevention and therapeutic support. It contains a variety of biologically active phyto-compounds that show a vast array of pharmacological properties, including anti-inflammatory, anti-cardiovascular, anti-oxidant, anti-cancer, anti-diabetic, anti-periodontal, anti-microbial, anti-goiter, neuroprotective, and immunomodulatory effect, etc. Purpose: This comprehensive review divulges the existing knowledge from research literature on Ascophyllum nodosum extract (ANE) and offers suggestions for future research on its potential against human diseases. Methods: To ensure a comprehensive search, we reviewed peer-reviewed articles on Ascophyllum nodosum extract (ANE) and its active constituents using several online databases, including Google Scholar, PubMed, ResearchGate, and Web of Science. We used targeted keywords, such as “Ascophyllum nodosum extract,” “pharmacological properties,” “therapeutic applications,” and “bioactive compounds,” to ensure a focused collection of high-quality studies relevant to ANE's health benefits. Additionally, the search included only English-language articles published within the last decade, with an emphasis on research from the past five years to ensure currency and relevance. Older but foundational studies were also retained to provide historical context and background. This structured approach allowed us to gather a range of high-quality articles directly supporting ANE's potential in various therapeutic contexts. Results: We conducted a comprehensive review of the research progress on ANE, focusing on its pharmacological effects on various diseases using animal models, mechanisms of action, and composition, are as not explored in preceding reviews. Additionally, we examined the bioactive ingredients in ANE, highlighting their potential to address significant challenges in mitigating human diseases. Conclusions: In this comprehensive review, we present an overview of A. nodosum, highlighting its potential as a therapeutic agent for managing human diseases. The study of ANE in animal models shows promising prospects for ameliorating several human diseases. |
| format | Article |
| id | doaj-art-7322c64dd78a46ac9fe153b209786705 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-7322c64dd78a46ac9fe153b2097867052025-02-10T04:35:17ZengElsevierPhytomedicine Plus2667-03132025-02-0151100718Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive reviewBrijesh Singh Chauhan0Yash Pal Singh1Department of Cellular and Molecular Physiology, 500 University Drive Crescent Building C4605, Penn State College of Medicine, Hershey PA 17033, United States; Corresponding author at: Department of Cellular and Molecular Physiology, 500 University Drive Crescent Building C4605, Penn State College of Medicine, Hershey PA 17033, United States.Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, 23298, United StatesBackground: Ascophyllum nodosum, a brown alga, is a potential natural remedy with a diverse application for disease prevention and therapeutic support. It contains a variety of biologically active phyto-compounds that show a vast array of pharmacological properties, including anti-inflammatory, anti-cardiovascular, anti-oxidant, anti-cancer, anti-diabetic, anti-periodontal, anti-microbial, anti-goiter, neuroprotective, and immunomodulatory effect, etc. Purpose: This comprehensive review divulges the existing knowledge from research literature on Ascophyllum nodosum extract (ANE) and offers suggestions for future research on its potential against human diseases. Methods: To ensure a comprehensive search, we reviewed peer-reviewed articles on Ascophyllum nodosum extract (ANE) and its active constituents using several online databases, including Google Scholar, PubMed, ResearchGate, and Web of Science. We used targeted keywords, such as “Ascophyllum nodosum extract,” “pharmacological properties,” “therapeutic applications,” and “bioactive compounds,” to ensure a focused collection of high-quality studies relevant to ANE's health benefits. Additionally, the search included only English-language articles published within the last decade, with an emphasis on research from the past five years to ensure currency and relevance. Older but foundational studies were also retained to provide historical context and background. This structured approach allowed us to gather a range of high-quality articles directly supporting ANE's potential in various therapeutic contexts. Results: We conducted a comprehensive review of the research progress on ANE, focusing on its pharmacological effects on various diseases using animal models, mechanisms of action, and composition, are as not explored in preceding reviews. Additionally, we examined the bioactive ingredients in ANE, highlighting their potential to address significant challenges in mitigating human diseases. Conclusions: In this comprehensive review, we present an overview of A. nodosum, highlighting its potential as a therapeutic agent for managing human diseases. The study of ANE in animal models shows promising prospects for ameliorating several human diseases.http://www.sciencedirect.com/science/article/pii/S2667031324001921Ascophyllum nodosum extractPhytochemistryPharmacological effectsHuman diseases |
| spellingShingle | Brijesh Singh Chauhan Yash Pal Singh Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review Phytomedicine Plus Ascophyllum nodosum extract Phytochemistry Pharmacological effects Human diseases |
| title | Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review |
| title_full | Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review |
| title_fullStr | Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review |
| title_full_unstemmed | Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review |
| title_short | Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review |
| title_sort | phytochemistry and pharmacological advances of ascophyllum nodosum in the management of human diseases a comprehensive review |
| topic | Ascophyllum nodosum extract Phytochemistry Pharmacological effects Human diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001921 |
| work_keys_str_mv | AT brijeshsinghchauhan phytochemistryandpharmacologicaladvancesofascophyllumnodosuminthemanagementofhumandiseasesacomprehensivereview AT yashpalsingh phytochemistryandpharmacologicaladvancesofascophyllumnodosuminthemanagementofhumandiseasesacomprehensivereview |