Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review
Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers and generally has a poor prognosis. The hierarchical model, which posits that HCC originates from liver cancer stem cells (CSCs), is now widely accepted, as it is for other cancer types. As CSCs typically reside in the G...
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Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
2025-01-01
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| Series: | Journal of Yeungnam Medical Science |
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| Online Access: | http://www.e-jyms.org/upload/pdf/jyms-2024-01088.pdf |
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| author | Jong Ryeol Eun |
| author_facet | Jong Ryeol Eun |
| author_sort | Jong Ryeol Eun |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers and generally has a poor prognosis. The hierarchical model, which posits that HCC originates from liver cancer stem cells (CSCs), is now widely accepted, as it is for other cancer types. As CSCs typically reside in the G0 phase of the cell cycle, they are resistant to conventional chemotherapy. Therefore, to effectively treat HCC, developing therapeutic strategies that target liver CSCs is essential. Clinically, HCCs exhibit a broad spectrum of pathological and clinical characteristics, ranging from well-differentiated to poorly differentiated forms, and from slow-growing tumors to aggressive ones with significant metastatic potential. Some patients with HCC also show features of cholangiocarcinoma. This HCC heterogeneity may arise from the diverse cellular origins of liver CSCs. This review explores the normal physiology of liver regeneration and provides a comprehensive overview of hepatocarcinogenesis, including cancer initiation, isolation of liver CSCs, molecular signaling pathways, and microRNAs. Additionally, the cellular origins of liver CSCs are reviewed, emphasizing hematopoietic and mesenchymal stem cells, along with the well-known hepatocytes and hepatic progenitor cells. |
| format | Article |
| id | doaj-art-73531b297b1d4de4a4677d342f3bd35d |
| institution | Kabale University |
| issn | 2799-8010 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
| record_format | Article |
| series | Journal of Yeungnam Medical Science |
| spelling | doaj-art-73531b297b1d4de4a4677d342f3bd35d2025-02-11T06:26:37ZengYeungnam University College of Medicine, Yeungnam University Institute Medical ScienceJournal of Yeungnam Medical Science2799-80102025-01-014210.12701/jyms.2024.010882865Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative reviewJong Ryeol Eun0 Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Ilsan, KoreaHepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers and generally has a poor prognosis. The hierarchical model, which posits that HCC originates from liver cancer stem cells (CSCs), is now widely accepted, as it is for other cancer types. As CSCs typically reside in the G0 phase of the cell cycle, they are resistant to conventional chemotherapy. Therefore, to effectively treat HCC, developing therapeutic strategies that target liver CSCs is essential. Clinically, HCCs exhibit a broad spectrum of pathological and clinical characteristics, ranging from well-differentiated to poorly differentiated forms, and from slow-growing tumors to aggressive ones with significant metastatic potential. Some patients with HCC also show features of cholangiocarcinoma. This HCC heterogeneity may arise from the diverse cellular origins of liver CSCs. This review explores the normal physiology of liver regeneration and provides a comprehensive overview of hepatocarcinogenesis, including cancer initiation, isolation of liver CSCs, molecular signaling pathways, and microRNAs. Additionally, the cellular origins of liver CSCs are reviewed, emphasizing hematopoietic and mesenchymal stem cells, along with the well-known hepatocytes and hepatic progenitor cells.http://www.e-jyms.org/upload/pdf/jyms-2024-01088.pdfcellular originshepatocarcinogenesishepatocellular carcinomaliver cancer stem cells |
| spellingShingle | Jong Ryeol Eun Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review Journal of Yeungnam Medical Science cellular origins hepatocarcinogenesis hepatocellular carcinoma liver cancer stem cells |
| title | Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review |
| title_full | Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review |
| title_fullStr | Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review |
| title_full_unstemmed | Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review |
| title_short | Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review |
| title_sort | overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells a narrative review |
| topic | cellular origins hepatocarcinogenesis hepatocellular carcinoma liver cancer stem cells |
| url | http://www.e-jyms.org/upload/pdf/jyms-2024-01088.pdf |
| work_keys_str_mv | AT jongryeoleun overviewofhepatocarcinogenesisfocusingoncellularoriginsoflivercancerstemcellsanarrativereview |