Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy
Background: Disturbances in sleep have a wide-ranging effect on a child’s life profoundly impacting the standard of living. The aim of this study was to investigate levels of Salivary Tumor Necrosis Factor-Alpha (TNF-α) and Malondialdehyde (MDA) in a group of children with class II malocclusion and...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-10-01
|
| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijdr.ijdr_88_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825202069976383488 |
|---|---|
| author | Trupti Balasaheb Bhosale Vabitha Shetty |
| author_facet | Trupti Balasaheb Bhosale Vabitha Shetty |
| author_sort | Trupti Balasaheb Bhosale |
| collection | DOAJ |
| description | Background:
Disturbances in sleep have a wide-ranging effect on a child’s life profoundly impacting the standard of living. The aim of this study was to investigate levels of Salivary Tumor Necrosis Factor-Alpha (TNF-α) and Malondialdehyde (MDA) in a group of children with class II malocclusion and sleep problems before and after twin block appliance therapy.
Materials and Methods:
Eleven children aged 8–12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study. All children were subjected to a recording of their sleep history and a clinical and radiographic examination. Pre-treatment levels of salivary TNF-α and MDA were recorded. A twin block appliance was custom made and delivered to every child. After a minimum follow-up period of 9 months, all children were recalled for a re-evaluation of salivary biomarker levels.
Results:
Levels of salivary biomarkers TNF-α and MDA significantly decreased in children following myofunctional therapy using a twin block appliance.
Conclusion:
The measurement of TNF-α and MDA could be used as an alternative and noninvasive method to evaluate prognosis of twin block therapy for children with sleep-disordered breathing (SDB). |
| format | Article |
| id | doaj-art-7445c20cb6f04af2bf8faef8645e799f |
| institution | Kabale University |
| issn | 0970-9290 1998-3603 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj-art-7445c20cb6f04af2bf8faef8645e799f2025-02-07T15:30:50ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032023-10-0134439139510.4103/ijdr.ijdr_88_23Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block TherapyTrupti Balasaheb BhosaleVabitha ShettyBackground: Disturbances in sleep have a wide-ranging effect on a child’s life profoundly impacting the standard of living. The aim of this study was to investigate levels of Salivary Tumor Necrosis Factor-Alpha (TNF-α) and Malondialdehyde (MDA) in a group of children with class II malocclusion and sleep problems before and after twin block appliance therapy. Materials and Methods: Eleven children aged 8–12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study. All children were subjected to a recording of their sleep history and a clinical and radiographic examination. Pre-treatment levels of salivary TNF-α and MDA were recorded. A twin block appliance was custom made and delivered to every child. After a minimum follow-up period of 9 months, all children were recalled for a re-evaluation of salivary biomarker levels. Results: Levels of salivary biomarkers TNF-α and MDA significantly decreased in children following myofunctional therapy using a twin block appliance. Conclusion: The measurement of TNF-α and MDA could be used as an alternative and noninvasive method to evaluate prognosis of twin block therapy for children with sleep-disordered breathing (SDB).https://journals.lww.com/10.4103/ijdr.ijdr_88_23malondialdehydeobstructive sleep apneasalivary biomarkerstumor necrosis factor-alphatwin block appliance |
| spellingShingle | Trupti Balasaheb Bhosale Vabitha Shetty Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy Indian Journal of Dental Research malondialdehyde obstructive sleep apnea salivary biomarkers tumor necrosis factor-alpha twin block appliance |
| title | Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy |
| title_full | Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy |
| title_fullStr | Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy |
| title_full_unstemmed | Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy |
| title_short | Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy |
| title_sort | salivary biomarker levels in children with sleep problems before and after twin block therapy |
| topic | malondialdehyde obstructive sleep apnea salivary biomarkers tumor necrosis factor-alpha twin block appliance |
| url | https://journals.lww.com/10.4103/ijdr.ijdr_88_23 |
| work_keys_str_mv | AT truptibalasahebbhosale salivarybiomarkerlevelsinchildrenwithsleepproblemsbeforeandaftertwinblocktherapy AT vabithashetty salivarybiomarkerlevelsinchildrenwithsleepproblemsbeforeandaftertwinblocktherapy |