Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats

Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats

Summary Female sex and Apolipoprotein (APOE) ε4 genotype are top risk factors for late-onset Alzheimer’s disease. This research investigates how these two risk factors might interact to influence biomarkers of brain health at middle age using a rat model. Compared to healthy controls, male rats with...

Full description

Saved in:

Bibliographic Details
Main Authors:	Bonnie H. Lee, Melike Cevizci, Stephanie E. Lieblich, Liisa A. M. Galea
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	Biology of Sex Differences
Subjects:	Sex differences Alzheimer’s disease Hippocampus Microglia Male Female
Online Access:	https://doi.org/10.1186/s13293-025-00694-8
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s disease
by: Anett Futácsi, et al.
Published: (2025-02-01)

Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia
by: Haolin Zheng, et al.
Published: (2025-02-01)

SEX PREFERENCE IN MATERNAL HEALTH IN LOKOJA KOGI STATE
by: Silas Joshua, et al.
Published: (2023-08-01)

Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis
by: Shasha Huang, et al.
Published: (2025-01-01)

Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease
by: Zhou H, et al.
Published: (2025-02-01)

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
by: Shaowei Wang, et al.
Published: (2025-02-01)

Sex Work in Public Administration: Creating a Welcoming Environment
by: Seth J. Meyer
Published: (2025-01-01)

Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats.
by: Nabirumbi, Ritah, et al.
Published: (2024)

Effect of 17α-methyl testosterone on sex reversal and growth performance of Nile tilapia,Oreochromis niloticus
by: Belete Berhanu, et al.
Published: (2023-12-01)

Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction
by: Jingrun Lin, et al.
Published: (2025-02-01)

Functional segregation of rostral and caudal hippocampus in associative memory
by: Alicia Nunez Vorobiova, et al.
Published: (2025-02-01)

Analysis of Amelogenin and Sex-determining Region on Y Chromosome Genes Obtained from Pulpal Tissue for Sex Estimation by using Multiplex Polymerase Chain Reaction
by: Mohammed Taha Ahmed Baban, et al.
Published: (2023-12-01)

The influence of sex on sleep characteristics in the adult and older adult population: findings from the EPISONO sleep study
by: Mayra dos Santos Silva, et al.
Published: (2025-02-01)

Socioeconomic factors and sex effects of postpartum maternal depression on offspring internalizing symptoms: a systematic review and meta-analysis
by: Yang Geng, et al.
Published: (2025-02-01)

Analysis of the Impact of Media on Premarital Sex in Central Division Kabale Municipality.
by: Kamusiime, Phabith
Published: (2024)

Editorial: 15 years of Frontiers in Cellular Neuroscience: the dual role of microglia in (neuro)inflammation
by: Antonio J. Herrera, et al.
Published: (2025-02-01)

Sex and hand differences in haptic processing: implications for mental rotation ability
by: Daniela E. Aguilar Ramirez, et al.
Published: (2025-02-01)

Enrollment and Retention of Female Sex Workers in HIV Care in Health Facilities in Mbarara City.
by: Arinaitwe, Bridget, et al.
Published: (2024)

Impact of fetal sex on neonatal outcomes in women with gestational diabetes mellitus: a systematic review and meta-analysis
by: Mahsa Maghalian, et al.
Published: (2025-02-01)

Role of Social Factors in Promoting Premarital Sex in Central Division Kabale Municipality.
by: Nansubuga, Maryliz
Published: (2024)

Danggui-Shaoyao-San Can Ameliorate Alzheimer’s Disease by Inhibiting Hippocampal Neuron Apoptosis: Findings from Serum Pharmacology
by: Zhang KX, et al.
Published: (2025-02-01)

Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2
by: Siyao Li, et al.
Published: (2025-01-01)

Lactoferrin alleviates the adverse effects of early-life inflammation on depression in adults by regulating the activation of microglia
by: Wenli Wang, et al.
Published: (2025-02-01)

Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2
by: Xia Yin, et al.
Published: (2025-02-01)

The Effects of Premarital Sex on Students Academic Performance in Secondary Schools of Northern Division Kabale Municipality.
by: Tumwekwase, Sarah
Published: (2024)

Men’s internet sex addiction predicts sexual objectification of women even after taking pornography consumption frequency into account
by: Pavla Novakova, et al.
Published: (2025-02-01)

The Impact of Sex Education Towards Moral Development Among Pupils in Kebisoni Sub-County Rukungiri District.
by: Kamagara, Annet
Published: (2024)

Machine learning reveals sex differences in distinguishing between conduct-disordered and neurotypical youth based on emotion processing dysfunction
by: Gregor Kohls, et al.
Published: (2025-02-01)

RELATIONSHIP OF ACL INJURY WITH POSTERIOR TIBIAL SLOPE, INTERCONDYLAR NOTCH WIDTH RATIO, AGE, AND SEX
by: Boby Harul Priono, et al.
Published: (2019-12-01)

Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2
by: Huinan Zhang, et al.
Published: (2025-03-01)

Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section
by: Mathieu Di Miceli, et al.
Published: (2024-11-01)

Fighting Alzheimer’s with Movement: The Role of Physical Activity in Disease Management
by: Agnieszka Kosińska, et al.
Published: (2025-02-01)

A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction
by: Gwyneth Kong, et al.
Published: (2025-02-01)

The Science of Memory Loss: Insights into Alzheimer’s Disease
by: Agnieszka Starzyk, et al.
Published: (2025-02-01)

Exposure to Lead (Pb) influences the outcomes of male-male competition during precopulatory intrasexual selection
by: Rosemary Patrick, et al.
Published: (2024-10-01)

Activating PKC-ε induces HIV expression with improved tolerability.
by: Alivelu M Irrinki, et al.
Published: (2025-02-01)

The Translation of Ὑποκριτης in the Gospels as Osatotsε in Dangme Bible Translations
by: Ebenezer Quaye, et al.
Published: (2024-12-01)

<i>Lady urologist</i> and male patients with prostate cancer
by: Rodolfo Montironi, et al.
Published: (2025-02-01)

The history of sexuality /
by: Foucault, Michel, 1926-1984
Published: (1978)

EXISTIRÁ UMA VIDA APÓS O DESENVOLVIMENTO?
by: Serge Latouche
Published: (2014-03-01)