Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study
Michał Kania,1,2 Michał Terlecki,2,3 Krzysztof Batko,2 Marek Rajzer,2,3 Maciej T Malecki,1,2 Marcin Krzanowski2,4 1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland; 2University Hospital, Krakow, Poland; 3Department of Cardiology, Interve...
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Dove Medical Press
2025-02-01
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| author | Kania M Terlecki M Batko K Rajzer M Malecki MT Krzanowski M |
| author_facet | Kania M Terlecki M Batko K Rajzer M Malecki MT Krzanowski M |
| author_sort | Kania M |
| collection | DOAJ |
| description | Michał Kania,1,2 Michał Terlecki,2,3 Krzysztof Batko,2 Marek Rajzer,2,3 Maciej T Malecki,1,2 Marcin Krzanowski2,4 1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland; 2University Hospital, Krakow, Poland; 3Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Krakow, Poland; 4Department of Nephrology and Transplantology, Jagiellonian University Medical College, Krakow, PolandCorrespondence: Marcin Krzanowski, Jagiellonian University Medical College, Department of Nephrology, 2 Jakubowskiego Str, 30-688, Krakow, Poland, Email [email protected] and Hypothesis: Chronic kidney disease (CKD) is a major prognostic factor in COVID-19. Little is known about the significance of newly detected renal impairment (RI) for COVID-19 patient outcomes. This study assessed the effect of prior CKD and RI at admission on in-hospital mortality in COVID-19 patients.Methods: A total of 5191 consecutive patients with COVID-19 admitted between March 6, 2020 and May 31, 2021, to the University Hospital in Krakow were analyzed. The main outcome was in-hospital death from any cause compared between the three study groups – patients with a prior history of CKD (group A), no history of CKD and eGFR on admission < 60 mL/min/1,73 m2 (group B), and no history of CKD and eGFR on admission > 60 mL/min/1,73 m2 (group C).Results: Of 5191 patients, 2348 (45.2%) were women and 2409 (46.4%) were older than 65 years (mean age of 61.98± 16.66 years). There were 483 (9.3%) patients in group A, 1009 (22.2%) in group B and 3699 (68.5%) in group C. Groups A and B were older and had higher cardiometabolic burden compared to group C. Multivariable logistic regression showed that older age, higher CRP, WBC, D-dimer levels, HF, and being in groups A or B were associated with higher in-hospital mortality. Group B had the highest risk (OR 3.003, CI 2.298– 3.926) compared to group A (OR 2.020, CI 1.636– 2.494) and group C (reference).Conclusion: COVID-19 patients with prior CKD and newly detected RI have higher odds of in-hospital death compared to those with normal kidney function. Special attention is needed for newly detected RI cases in COVID-19 patients.Keywords: kidney disease, mortality, risk factors, COVID-19, chronic kidney disease, acute kidney injury, SARS-Cov-2 |
| format | Article |
| id | doaj-art-75214e76b6104b0c9bc86c35e52b1ed1 |
| institution | Kabale University |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
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| series | International Journal of General Medicine |
| spelling | doaj-art-75214e76b6104b0c9bc86c35e52b1ed12025-02-06T16:40:24ZengDove Medical PressInternational Journal of General Medicine1178-70742025-02-01Volume 1859360299924Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort StudyKania MTerlecki MBatko KRajzer MMalecki MTKrzanowski MMichał Kania,1,2 Michał Terlecki,2,3 Krzysztof Batko,2 Marek Rajzer,2,3 Maciej T Malecki,1,2 Marcin Krzanowski2,4 1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland; 2University Hospital, Krakow, Poland; 3Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Krakow, Poland; 4Department of Nephrology and Transplantology, Jagiellonian University Medical College, Krakow, PolandCorrespondence: Marcin Krzanowski, Jagiellonian University Medical College, Department of Nephrology, 2 Jakubowskiego Str, 30-688, Krakow, Poland, Email [email protected] and Hypothesis: Chronic kidney disease (CKD) is a major prognostic factor in COVID-19. Little is known about the significance of newly detected renal impairment (RI) for COVID-19 patient outcomes. This study assessed the effect of prior CKD and RI at admission on in-hospital mortality in COVID-19 patients.Methods: A total of 5191 consecutive patients with COVID-19 admitted between March 6, 2020 and May 31, 2021, to the University Hospital in Krakow were analyzed. The main outcome was in-hospital death from any cause compared between the three study groups – patients with a prior history of CKD (group A), no history of CKD and eGFR on admission < 60 mL/min/1,73 m2 (group B), and no history of CKD and eGFR on admission > 60 mL/min/1,73 m2 (group C).Results: Of 5191 patients, 2348 (45.2%) were women and 2409 (46.4%) were older than 65 years (mean age of 61.98± 16.66 years). There were 483 (9.3%) patients in group A, 1009 (22.2%) in group B and 3699 (68.5%) in group C. Groups A and B were older and had higher cardiometabolic burden compared to group C. Multivariable logistic regression showed that older age, higher CRP, WBC, D-dimer levels, HF, and being in groups A or B were associated with higher in-hospital mortality. Group B had the highest risk (OR 3.003, CI 2.298– 3.926) compared to group A (OR 2.020, CI 1.636– 2.494) and group C (reference).Conclusion: COVID-19 patients with prior CKD and newly detected RI have higher odds of in-hospital death compared to those with normal kidney function. Special attention is needed for newly detected RI cases in COVID-19 patients.Keywords: kidney disease, mortality, risk factors, COVID-19, chronic kidney disease, acute kidney injury, SARS-Cov-2https://www.dovepress.com/impact-of-prior-chronic-kidney-disease-and-newly-detected-egfr-impairm-peer-reviewed-fulltext-article-IJGMkidney diseasemortalityrisk factorscovid-19chronic kidney diseaseacute kidney injurysars-cov-2 |
| spellingShingle | Kania M Terlecki M Batko K Rajzer M Malecki MT Krzanowski M Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study International Journal of General Medicine kidney disease mortality risk factors covid-19 chronic kidney disease acute kidney injury sars-cov-2 |
| title | Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study |
| title_full | Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study |
| title_fullStr | Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study |
| title_full_unstemmed | Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study |
| title_short | Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients – A Single-Center Cohort Study |
| title_sort | impact of prior chronic kidney disease and newly detected egfr impairment at admission on outcomes and prognosis of hospitalized covid 19 patients ndash a single center cohort study |
| topic | kidney disease mortality risk factors covid-19 chronic kidney disease acute kidney injury sars-cov-2 |
| url | https://www.dovepress.com/impact-of-prior-chronic-kidney-disease-and-newly-detected-egfr-impairm-peer-reviewed-fulltext-article-IJGM |
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