Reducing M2 macrophage in lung fibrosis by controlling anti-M1 agent

Reducing M2 macrophage in lung fibrosis by controlling anti-M1 agent

Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by excessive scarring and fibrosis due to the abnormal accumulation of extracellular matrix components, primarily collagen. This study aims to design and solve an optimal control problem to regulate M2 macrophage ac...

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Bibliographic Details
Main Authors: Fatemeh Bahram Yazdroudi, Alaeddin Malek
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Anti-M1 agent
Canonical Hamiltonian
Diffusion equation
Dynamical system
Extended Riccati equations
Lung fibrosis
Online Access:https://doi.org/10.1038/s41598-024-76561-0
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