Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study
BackgroundRecently, weight-adjusted-waist index (WWI), a new index for evaluating obesity, has been developed. This study aimed to examine the association between WWI and T2DM in Chinese urban adults.MethodA total of 5,0978 eligible participants drawn from the prospective REACTION study (Cancer Risk...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1460230/full |
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| author | Qingzheng Wu Bing Li Yuepeng Wang Yuepeng Wang Yue Zhang Qian Wang Binqi Li Binqi Li Wei Jing Jing Yang Yiming Mu |
| author_facet | Qingzheng Wu Bing Li Yuepeng Wang Yuepeng Wang Yue Zhang Qian Wang Binqi Li Binqi Li Wei Jing Jing Yang Yiming Mu |
| author_sort | Qingzheng Wu |
| collection | DOAJ |
| description | BackgroundRecently, weight-adjusted-waist index (WWI), a new index for evaluating obesity, has been developed. This study aimed to examine the association between WWI and T2DM in Chinese urban adults.MethodA total of 5,0978 eligible participants drawn from the prospective REACTION study (Cancer Risk Assessment in Chinese People with Diabetes) were included in this study. Participants were divided into 3 groups based on baseline WWI levels. Pearson correlation analysis and binary logistic regression analysis were conducted to explore the association of WWI with T2DM risk factors and with T2DM risk.ResultsThe prevalence of obesity, central obesity and T2DM was 14.2%, 46.8% and 11.0% respectively, with a median age of 57 years. Logistic analysis showed that the WWI was significantly associated with the risk of T2DM. Compared to the lowest tertile of WWI (T1) serving as the reference group, the second tertile (T2) and the third tertile (T3) were associated with a 0.218-fold [1.218 (1.152, 1.288), P <0.001] and 0.286-fold [1.286 (1.212, 1.364), P <0.001] increase in the odds of developing T2DM respectively. After adjusting for all factors with the exception of the stratified variable, this association held true in age, sex, BMI, hypertension, and hyperlipidemia subgroup and was especially pronounced in those aged <60 years, BMI ≥24 kg/m2, and males, with interactions between WWI and age, sex, and BMI (P for interaction <0.05).ConclusionWWI was positively associated with T2DM in Chinese urban adults, especially in young and middle-aged males with BMI ≥24 kg/m2. |
| format | Article |
| id | doaj-art-7596247bbe5d4e3d92b4bf477444602e |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-7596247bbe5d4e3d92b4bf477444602e2025-02-10T05:16:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14602301460230Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional studyQingzheng Wu0Bing Li1Yuepeng Wang2Yuepeng Wang3Yue Zhang4Qian Wang5Binqi Li6Binqi Li7Wei Jing8Jing Yang9Yiming Mu10Department of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Anesthesiology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaNanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaBackgroundRecently, weight-adjusted-waist index (WWI), a new index for evaluating obesity, has been developed. This study aimed to examine the association between WWI and T2DM in Chinese urban adults.MethodA total of 5,0978 eligible participants drawn from the prospective REACTION study (Cancer Risk Assessment in Chinese People with Diabetes) were included in this study. Participants were divided into 3 groups based on baseline WWI levels. Pearson correlation analysis and binary logistic regression analysis were conducted to explore the association of WWI with T2DM risk factors and with T2DM risk.ResultsThe prevalence of obesity, central obesity and T2DM was 14.2%, 46.8% and 11.0% respectively, with a median age of 57 years. Logistic analysis showed that the WWI was significantly associated with the risk of T2DM. Compared to the lowest tertile of WWI (T1) serving as the reference group, the second tertile (T2) and the third tertile (T3) were associated with a 0.218-fold [1.218 (1.152, 1.288), P <0.001] and 0.286-fold [1.286 (1.212, 1.364), P <0.001] increase in the odds of developing T2DM respectively. After adjusting for all factors with the exception of the stratified variable, this association held true in age, sex, BMI, hypertension, and hyperlipidemia subgroup and was especially pronounced in those aged <60 years, BMI ≥24 kg/m2, and males, with interactions between WWI and age, sex, and BMI (P for interaction <0.05).ConclusionWWI was positively associated with T2DM in Chinese urban adults, especially in young and middle-aged males with BMI ≥24 kg/m2.https://www.frontiersin.org/articles/10.3389/fendo.2025.1460230/fullobesitycentral adipositytype 2 diabetes mellitusweight-adjusted-waist indexreactionChinese urban adults |
| spellingShingle | Qingzheng Wu Bing Li Yuepeng Wang Yuepeng Wang Yue Zhang Qian Wang Binqi Li Binqi Li Wei Jing Jing Yang Yiming Mu Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study Frontiers in Endocrinology obesity central adiposity type 2 diabetes mellitus weight-adjusted-waist index reaction Chinese urban adults |
| title | Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study |
| title_full | Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study |
| title_fullStr | Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study |
| title_full_unstemmed | Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study |
| title_short | Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study |
| title_sort | association of weight adjusted waist index with type 2 diabetes mellitus in chinese urban adults a cross sectional study |
| topic | obesity central adiposity type 2 diabetes mellitus weight-adjusted-waist index reaction Chinese urban adults |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1460230/full |
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