A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
A bidirectional nucleus-mitochondria communication is essential for homeostasis and stress. By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. However, role of mitochondrial-derived lncRNAs (mtlncRNAs)...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1011580 |
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| author | Jia Li Ruoling Bai Yulian Zhou Xu Song Ling Li |
| author_facet | Jia Li Ruoling Bai Yulian Zhou Xu Song Ling Li |
| author_sort | Jia Li |
| collection | DOAJ |
| description | A bidirectional nucleus-mitochondria communication is essential for homeostasis and stress. By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. However, role of mitochondrial-derived lncRNAs (mtlncRNAs) in the mitochondria-to-nucleus retrograde regulation remains elusive. Here, we identify functional implication of the mtlncRNAs MDL1AS, lncND5 and lncCyt b in retrograde regulation. Mediated by HuR and PNPT1 proteins, the mtlncRNAs undergo a mitochondria-to-nucleus traveling and then regulate a network of nuclear genes. Moreover, as an example of the functional consequence, we showed that the nuclear-translocated lncCyt b cooperates with the splicing factor hnRNPA2B1 to influence several aspects of cell metabolism including glycolysis, possibly through their regulatory effect on the post-transcriptional processing of related nuclear genes. This study advances our knowledge in mitochondrial biology and provides new insights into the role of mtlncRNAs in mitochondria-nucleus communications. |
| format | Article |
| id | doaj-art-762f77410cc341a58e308063b4c55fa1 |
| institution | Kabale University |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-762f77410cc341a58e308063b4c55fa12025-02-12T05:30:47ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042025-01-01211e101158010.1371/journal.pgen.1011580A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.Jia LiRuoling BaiYulian ZhouXu SongLing LiA bidirectional nucleus-mitochondria communication is essential for homeostasis and stress. By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. However, role of mitochondrial-derived lncRNAs (mtlncRNAs) in the mitochondria-to-nucleus retrograde regulation remains elusive. Here, we identify functional implication of the mtlncRNAs MDL1AS, lncND5 and lncCyt b in retrograde regulation. Mediated by HuR and PNPT1 proteins, the mtlncRNAs undergo a mitochondria-to-nucleus traveling and then regulate a network of nuclear genes. Moreover, as an example of the functional consequence, we showed that the nuclear-translocated lncCyt b cooperates with the splicing factor hnRNPA2B1 to influence several aspects of cell metabolism including glycolysis, possibly through their regulatory effect on the post-transcriptional processing of related nuclear genes. This study advances our knowledge in mitochondrial biology and provides new insights into the role of mtlncRNAs in mitochondria-nucleus communications.https://doi.org/10.1371/journal.pgen.1011580 |
| spellingShingle | Jia Li Ruoling Bai Yulian Zhou Xu Song Ling Li A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. PLoS Genetics |
| title | A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. |
| title_full | A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. |
| title_fullStr | A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. |
| title_full_unstemmed | A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. |
| title_short | A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. |
| title_sort | mitochondria to nucleus regulation mediated by the nuclear translocated mitochondrial lncrnas |
| url | https://doi.org/10.1371/journal.pgen.1011580 |
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