Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), which is highly expressed in the central nervous system, is known to be involved in the regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. This knowledge indicates a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1454735/full |
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| author | Mi-bo Tang Yi-xuan Liu Zheng-wei Hu Hai-yang Luo Shuo Zhang Chang-he Shi Yu-ming Xu Yu-ming Xu Yu-ming Xu |
| author_facet | Mi-bo Tang Yi-xuan Liu Zheng-wei Hu Hai-yang Luo Shuo Zhang Chang-he Shi Yu-ming Xu Yu-ming Xu Yu-ming Xu |
| author_sort | Mi-bo Tang |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), which is highly expressed in the central nervous system, is known to be involved in the regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. This knowledge indicates a potential role of PGC-1α in a wide range of functions associated with neurological diseases. There is emerging evidence indicating a protective role of PGC-1α in the pathogenesis of several neurological diseases. As such, a deeper and broader understanding of PGC-1α and its role in neurological diseases is urgently needed. The present review provides a relatively complete overview of the current knowledge on PGC-1α, including its functions in different types of neurons, basic structural characteristics, and its interacting transcription factors. Furthermore, we present the role of PGC-1α in the pathogenesis of various neurological diseases, such as intracerebral hemorrhage, ischemic stroke, Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, and other PolyQ diseases. Importantly, we discuss some compounds or drug-targeting strategies that have been studied to ameliorate the pathology of these neurological diseases and introduce the possible mechanistic pathways. Based on the available studies, we propose that targeting PGC-1α could serve as a promising novel therapeutic strategy for one or more neurological diseases. |
| format | Article |
| id | doaj-art-776a4311f2e848a08aa62d1934b364a2 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-776a4311f2e848a08aa62d1934b364a22025-02-12T07:26:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011610.3389/fnagi.2024.14547351454735Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potentialMi-bo Tang0Yi-xuan Liu1Zheng-wei Hu2Hai-yang Luo3Shuo Zhang4Chang-he Shi5Yu-ming Xu6Yu-ming Xu7Yu-ming Xu8Department of Geriatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaNHC Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Zhengzhou, Henan, ChinaHenan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, Henan, ChinaPeroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), which is highly expressed in the central nervous system, is known to be involved in the regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. This knowledge indicates a potential role of PGC-1α in a wide range of functions associated with neurological diseases. There is emerging evidence indicating a protective role of PGC-1α in the pathogenesis of several neurological diseases. As such, a deeper and broader understanding of PGC-1α and its role in neurological diseases is urgently needed. The present review provides a relatively complete overview of the current knowledge on PGC-1α, including its functions in different types of neurons, basic structural characteristics, and its interacting transcription factors. Furthermore, we present the role of PGC-1α in the pathogenesis of various neurological diseases, such as intracerebral hemorrhage, ischemic stroke, Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, and other PolyQ diseases. Importantly, we discuss some compounds or drug-targeting strategies that have been studied to ameliorate the pathology of these neurological diseases and introduce the possible mechanistic pathways. Based on the available studies, we propose that targeting PGC-1α could serve as a promising novel therapeutic strategy for one or more neurological diseases.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1454735/fullPGC-1αmitochondrianeuroinflammationoxidative stressneurological diseases |
| spellingShingle | Mi-bo Tang Yi-xuan Liu Zheng-wei Hu Hai-yang Luo Shuo Zhang Chang-he Shi Yu-ming Xu Yu-ming Xu Yu-ming Xu Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential Frontiers in Aging Neuroscience PGC-1α mitochondria neuroinflammation oxidative stress neurological diseases |
| title | Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential |
| title_full | Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential |
| title_fullStr | Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential |
| title_full_unstemmed | Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential |
| title_short | Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential |
| title_sort | study insights in the role of pgc 1α in neurological diseases mechanisms and therapeutic potential |
| topic | PGC-1α mitochondria neuroinflammation oxidative stress neurological diseases |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1454735/full |
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