Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women

Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women

Abstract Background Mammographic breast density (MBD), a strong predictor of breast cancer, is highly influenced by body mass index (BMI) in childhood and early adulthood, but the mechanisms underlying these associations are not fully understood. Our goal is to identify biomarkers that mediate the a...

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Bibliographic Details
Main Authors: Kayla R. Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T. Toriola
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Breast Cancer Research
Subjects:
Early-life
Age 10
Age 18
Body mass index
Lipidomics
Mammographic breast density
Online Access:https://doi.org/10.1186/s13058-025-01970-6
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