Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series
Objective: New Delhi metallo-β-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) is a globally growing threat. We sought to describe the microbiology, management and outcomes of patients with this infection at our facility. Methods: This is a descriptive case series of patients w...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524004582 |
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| author | Anita Shallal Michael P. Veve Rachel M. Kenney George Alangaden Geehan Suleyman |
| author_facet | Anita Shallal Michael P. Veve Rachel M. Kenney George Alangaden Geehan Suleyman |
| author_sort | Anita Shallal |
| collection | DOAJ |
| description | Objective: New Delhi metallo-β-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) is a globally growing threat. We sought to describe the microbiology, management and outcomes of patients with this infection at our facility. Methods: This is a descriptive case series of patients with NDM-producing Escherichia coli isolated from culture in Detroit between July 2021 and February 2023. Demographics, risk factors, clinical characteristics, management and outcomes were described. Results: Nine patients were included in the study. Most patients were female with a median age of 67 years. Hepatobiliary disease accounted for 90% of underlying conditions. Nearly all patients had prior antibiotic exposure and the most common specimen source was intra-abdominal fluid. Three patients were not treated due to colonisation; among those treated, the majority received trimethoprim-sulfamethoxazole. The median treatment duration and length of stay were 7 and 15.5 days, respectively. Six (67%) patients survived. Conclusions: This report describes a large case series of NDM-producing E. coli infection. Patients with significant comorbidities remain at high risk for CRE infection. Antibiotic options for the treatment of NDM organisms are very limited; new and effective therapies are urgently needed. |
| format | Article |
| id | doaj-art-7942dccb88ff4bb1948afe968cc338be |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-7942dccb88ff4bb1948afe968cc338be2025-02-08T05:00:27ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-01-01404246Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case seriesAnita Shallal0Michael P. Veve1Rachel M. Kenney2George Alangaden3Geehan Suleyman4Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI, USADepartment of Pharmacy, Henry Ford Hospital, Detroit, MI, USA; Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USADepartment of Pharmacy, Henry Ford Hospital, Detroit, MI, USADivision of Infectious Diseases, Henry Ford Hospital, Detroit, MI, USADivision of Infectious Diseases, Henry Ford Hospital, Detroit, MI, USAObjective: New Delhi metallo-β-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) is a globally growing threat. We sought to describe the microbiology, management and outcomes of patients with this infection at our facility. Methods: This is a descriptive case series of patients with NDM-producing Escherichia coli isolated from culture in Detroit between July 2021 and February 2023. Demographics, risk factors, clinical characteristics, management and outcomes were described. Results: Nine patients were included in the study. Most patients were female with a median age of 67 years. Hepatobiliary disease accounted for 90% of underlying conditions. Nearly all patients had prior antibiotic exposure and the most common specimen source was intra-abdominal fluid. Three patients were not treated due to colonisation; among those treated, the majority received trimethoprim-sulfamethoxazole. The median treatment duration and length of stay were 7 and 15.5 days, respectively. Six (67%) patients survived. Conclusions: This report describes a large case series of NDM-producing E. coli infection. Patients with significant comorbidities remain at high risk for CRE infection. Antibiotic options for the treatment of NDM organisms are very limited; new and effective therapies are urgently needed.http://www.sciencedirect.com/science/article/pii/S2213716524004582Multi-drug resistant organismsCarbapenemase productionMetallo-β-lactamasesNDMCase seriesOral therapy |
| spellingShingle | Anita Shallal Michael P. Veve Rachel M. Kenney George Alangaden Geehan Suleyman Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series Journal of Global Antimicrobial Resistance Multi-drug resistant organisms Carbapenemase production Metallo-β-lactamases NDM Case series Oral therapy |
| title | Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series |
| title_full | Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series |
| title_fullStr | Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series |
| title_full_unstemmed | Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series |
| title_short | Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series |
| title_sort | characterisation management and outcomes of new delhi metallo β lactamase producing escherichia coli a case series |
| topic | Multi-drug resistant organisms Carbapenemase production Metallo-β-lactamases NDM Case series Oral therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524004582 |
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