Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model
Background: It is unknown whether ligation of supra-aortic vessels during thoraco-abdominal normothermic regional perfusion (TA-NRP) can prevent postmortem brain function, ensuring the permanence of death. Our objective was to determine if ligation of the supra-aortic vessels during TA-NRP prevents...
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Elsevier
2025-05-01
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| Series: | JHLT Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950133425000163 |
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| author | Matthieu Glorion, MD MSc Joel Neves Briard, MD MSc Louise Roquebert Sabina Pizzi Ahmed Menaouar, PhD Mélanie Borie, MSc Manon Robert, MSc Dang Khoa Nguyen, MD PhD Michaël Chassé, MD PhD Basil Nasir, MD Pasquale Ferraro, MD Shant Der Sarkissian, PhD, MBA Pierre-Emmanuel Noly, MD PhD Nicolas Noiseux, MD PhD |
| author_facet | Matthieu Glorion, MD MSc Joel Neves Briard, MD MSc Louise Roquebert Sabina Pizzi Ahmed Menaouar, PhD Mélanie Borie, MSc Manon Robert, MSc Dang Khoa Nguyen, MD PhD Michaël Chassé, MD PhD Basil Nasir, MD Pasquale Ferraro, MD Shant Der Sarkissian, PhD, MBA Pierre-Emmanuel Noly, MD PhD Nicolas Noiseux, MD PhD |
| author_sort | Matthieu Glorion, MD MSc |
| collection | DOAJ |
| description | Background: It is unknown whether ligation of supra-aortic vessels during thoraco-abdominal normothermic regional perfusion (TA-NRP) can prevent postmortem brain function, ensuring the permanence of death. Our objective was to determine if ligation of the supra-aortic vessels during TA-NRP prevents resumption of intracranial blood flow, brain electrical activity and clinical brain function in a porcine model of organ donation after circulatory arrest. Methods: Neuromonitoring was performed in 9 porcine experiments, in which supra-aortic vessels were ligated. Results: During TA-NRP and organ procurement, no motor reaction to pain, spontaneous ventilation, eye movement or change in pupillary function were observed. Angiography demonstrated absence of supra-aortic blood flow in 4 (44%) experiments and delayed, discrete and transient supra-aortic extracranial opacification in 5 (56%) experiments. No intracranial blood flow was observed. All electroencephalograms demonstrated absent brain electrical activity. Conclusion: In this porcine model, occlusion of the supra-aortic vessels during TA-NRP did not restore post-mortem cerebral blood flow or electrical activity and is in adequation with the permanence of death. |
| format | Article |
| id | doaj-art-798f5b17c3d94533b61f0d944ee5d33c |
| institution | Kabale University |
| issn | 2950-1334 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHLT Open |
| spelling | doaj-art-798f5b17c3d94533b61f0d944ee5d33c2025-02-12T05:33:17ZengElsevierJHLT Open2950-13342025-05-018100221Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine modelMatthieu Glorion, MD MSc0Joel Neves Briard, MD MSc1Louise Roquebert2Sabina Pizzi3Ahmed Menaouar, PhD4Mélanie Borie, MSc5Manon Robert, MSc6Dang Khoa Nguyen, MD PhD7Michaël Chassé, MD PhD8Basil Nasir, MD9Pasquale Ferraro, MD10Shant Der Sarkissian, PhD, MBA11Pierre-Emmanuel Noly, MD PhD12Nicolas Noiseux, MD PhD13Centre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Division of Thoracic Surgery, Department of Surgery, Université de Montréal, Montréal, Québec, Canada; Service de Chirurgie Thoracique, Hôpital Foch, Suresnes, FranceCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Department of Neuroscience, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Department of Neuroscience, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Division of Thoracic Surgery, Department of Surgery, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Division of Thoracic Surgery, Department of Surgery, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Department of Surgery, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Division of Cardiac Surgery, Department of Surgery, Université de Montréal, Montréal, Québec, CanadaCentre de Recherche du Centre Hospitalier de l′Université de Montréal (CRCHUM), Montréal, Québec, Canada; Division of Cardiac Surgery, Department of Surgery, Université de Montréal, Montréal, Québec, Canada; Corresponding author: Nicolas Noiseux, MD, PhD, Centre de Recherche du Centre hospitalier de l′Université de Montréal, 900 rue Saint-Denis, Montréal, Québec H2X 0A9.Background: It is unknown whether ligation of supra-aortic vessels during thoraco-abdominal normothermic regional perfusion (TA-NRP) can prevent postmortem brain function, ensuring the permanence of death. Our objective was to determine if ligation of the supra-aortic vessels during TA-NRP prevents resumption of intracranial blood flow, brain electrical activity and clinical brain function in a porcine model of organ donation after circulatory arrest. Methods: Neuromonitoring was performed in 9 porcine experiments, in which supra-aortic vessels were ligated. Results: During TA-NRP and organ procurement, no motor reaction to pain, spontaneous ventilation, eye movement or change in pupillary function were observed. Angiography demonstrated absence of supra-aortic blood flow in 4 (44%) experiments and delayed, discrete and transient supra-aortic extracranial opacification in 5 (56%) experiments. No intracranial blood flow was observed. All electroencephalograms demonstrated absent brain electrical activity. Conclusion: In this porcine model, occlusion of the supra-aortic vessels during TA-NRP did not restore post-mortem cerebral blood flow or electrical activity and is in adequation with the permanence of death.http://www.sciencedirect.com/science/article/pii/S2950133425000163organ donationcardiocirculatory deathanimal modelelectroencephalographyangiographythoraco-abdominal normothermic regional perfusion (TA-NRP) |
| spellingShingle | Matthieu Glorion, MD MSc Joel Neves Briard, MD MSc Louise Roquebert Sabina Pizzi Ahmed Menaouar, PhD Mélanie Borie, MSc Manon Robert, MSc Dang Khoa Nguyen, MD PhD Michaël Chassé, MD PhD Basil Nasir, MD Pasquale Ferraro, MD Shant Der Sarkissian, PhD, MBA Pierre-Emmanuel Noly, MD PhD Nicolas Noiseux, MD PhD Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model JHLT Open organ donation cardiocirculatory death animal model electroencephalography angiography thoraco-abdominal normothermic regional perfusion (TA-NRP) |
| title | Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model |
| title_full | Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model |
| title_fullStr | Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model |
| title_full_unstemmed | Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model |
| title_short | Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model |
| title_sort | thoraco abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra aortic blood flow in a porcine model |
| topic | organ donation cardiocirculatory death animal model electroencephalography angiography thoraco-abdominal normothermic regional perfusion (TA-NRP) |
| url | http://www.sciencedirect.com/science/article/pii/S2950133425000163 |
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