PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury
Poly (lactic-co-glycolic acid) (PLGA) is an important biomaterial for tissue defect repair, but its application in replacing missing brain tissue needs improvement. Mesenchymal stem cells (MSCs) have been used to treat various neurological diseases, but they face challenges when filling large tissue...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000280 |
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| author | Na Xu Zihuan Sun Weikang Guan Yiming Liu Yun Gao Chaoxian Yang |
| author_facet | Na Xu Zihuan Sun Weikang Guan Yiming Liu Yun Gao Chaoxian Yang |
| author_sort | Na Xu |
| collection | DOAJ |
| description | Poly (lactic-co-glycolic acid) (PLGA) is an important biomaterial for tissue defect repair, but its application in replacing missing brain tissue needs improvement. Mesenchymal stem cells (MSCs) have been used to treat various neurological diseases, but they face challenges when filling large tissue defects. The purpose of this study was to investigate the effects of PLGA combined with MSCs transplantation on brain structure and neural function in rats with traumatic brain injury (TBI), and explore its possible mechanism. The results showed that both PLGA transplantation and PLGA+MSCs transplantation could improve the brain structure and promote nerve function recovery in rats with TBI, with PLGA+MSCs transplantation being superior to PLGA transplantation. Furthermore, compared to PLGA transplantation alone, PLGA+MSCs transplantation further reduced brain injury and cell apoptosis, promoted neuron survival, and improved synaptic plasticity. Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI. |
| format | Article |
| id | doaj-art-79c6242e820a4d978314450d62a75e27 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-79c6242e820a4d978314450d62a75e272025-02-07T04:46:45ZengElsevierBrain Research Bulletin1873-27472025-02-01221111216PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injuryNa Xu0Zihuan Sun1Weikang Guan2Yiming Liu3Yun Gao4Chaoxian Yang5Department of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaDepartment of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaDazhou Central Hospital, Dazhou 635000, ChinaDepartment of Pediatrics, Southwest Medical University, Luzhou, ChinaDepartment of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China; Correspondence to: Department of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.Department of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China; Correspondence to: Department of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.Poly (lactic-co-glycolic acid) (PLGA) is an important biomaterial for tissue defect repair, but its application in replacing missing brain tissue needs improvement. Mesenchymal stem cells (MSCs) have been used to treat various neurological diseases, but they face challenges when filling large tissue defects. The purpose of this study was to investigate the effects of PLGA combined with MSCs transplantation on brain structure and neural function in rats with traumatic brain injury (TBI), and explore its possible mechanism. The results showed that both PLGA transplantation and PLGA+MSCs transplantation could improve the brain structure and promote nerve function recovery in rats with TBI, with PLGA+MSCs transplantation being superior to PLGA transplantation. Furthermore, compared to PLGA transplantation alone, PLGA+MSCs transplantation further reduced brain injury and cell apoptosis, promoted neuron survival, and improved synaptic plasticity. Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI.http://www.sciencedirect.com/science/article/pii/S0361923025000280Traumatic brain injuryPoly (lactic-co-glycolic acid)Mesenchymal stem cells |
| spellingShingle | Na Xu Zihuan Sun Weikang Guan Yiming Liu Yun Gao Chaoxian Yang PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury Brain Research Bulletin Traumatic brain injury Poly (lactic-co-glycolic acid) Mesenchymal stem cells |
| title | PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury |
| title_full | PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury |
| title_fullStr | PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury |
| title_full_unstemmed | PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury |
| title_short | PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury |
| title_sort | plga scaffold combined with mscs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury |
| topic | Traumatic brain injury Poly (lactic-co-glycolic acid) Mesenchymal stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000280 |
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