Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores
BackgroundVarious mechanical and biological requirements on bone scaffolds were proposed due to the clinical demands of human bone implants, which remains a challenge when designing appropriate bone scaffolds.MethodsIn this study, novel bone scaffolds were developed by introducing graded multi-funct...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1503582/full |
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| author | Rongwu Lai Rongwu Lai Jian Jiang Jian Jiang Yi Huo Hao Wang Sergei Bosiakov Yongtao Lyu Yongtao Lyu Lei Li |
| author_facet | Rongwu Lai Rongwu Lai Jian Jiang Jian Jiang Yi Huo Hao Wang Sergei Bosiakov Yongtao Lyu Yongtao Lyu Lei Li |
| author_sort | Rongwu Lai |
| collection | DOAJ |
| description | BackgroundVarious mechanical and biological requirements on bone scaffolds were proposed due to the clinical demands of human bone implants, which remains a challenge when designing appropriate bone scaffolds.MethodsIn this study, novel bone scaffolds were developed by introducing graded multi-functional pores onto Triply Periodic Minimal Surface (TPMS) structures through topology optimization of unit cell. The performance of these scaffolds was evaluated using finite element (FE) analysis and computational fluid dynamics (CFD) method.ResultsThe results from FE analysis indicated that the novel scaffold exhibited a lower elastic modulus, potentially mitigating the issue of stress shielding. Additionally, the results from CFD demonstrated that the mass transport capacity of the novel scaffold was significantly improved compared to conventional TPMS scaffolds.ConclusionIn summary, the novel TPMS scaffolds with graded multi-functional pores presented in this paper exhibited enhanced mechanical properties and mass transport capacity, making them ideal candidates for bone repair. A new design framework was provided for the development of high-performance bone scaffolds. |
| format | Article |
| id | doaj-art-7a57b714b7a14b45bbe25e26eaa7800b |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-7a57b714b7a14b45bbe25e26eaa7800b2025-02-12T07:25:36ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.15035821503582Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional poresRongwu Lai0Rongwu Lai1Jian Jiang2Jian Jiang3Yi Huo4Hao Wang5Sergei Bosiakov6Yongtao Lyu7Yongtao Lyu8Lei Li9Department of Spinal Surgery, Central Hospital of Dalian University of Technology, Dalian, ChinaSchool of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian, ChinaDepartment of Spinal Surgery, Central Hospital of Dalian University of Technology, Dalian, ChinaDepartment of Orthopaedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaSchool of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian, ChinaSchool of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian, ChinaFaculty of Mechanics and Mathematics, Belarusian State University, Minsk, BelarusSchool of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian, ChinaDUT-BSU Joint Institute, Dalian University of Technology, Dalian, ChinaDepartment of Orthopaedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaBackgroundVarious mechanical and biological requirements on bone scaffolds were proposed due to the clinical demands of human bone implants, which remains a challenge when designing appropriate bone scaffolds.MethodsIn this study, novel bone scaffolds were developed by introducing graded multi-functional pores onto Triply Periodic Minimal Surface (TPMS) structures through topology optimization of unit cell. The performance of these scaffolds was evaluated using finite element (FE) analysis and computational fluid dynamics (CFD) method.ResultsThe results from FE analysis indicated that the novel scaffold exhibited a lower elastic modulus, potentially mitigating the issue of stress shielding. Additionally, the results from CFD demonstrated that the mass transport capacity of the novel scaffold was significantly improved compared to conventional TPMS scaffolds.ConclusionIn summary, the novel TPMS scaffolds with graded multi-functional pores presented in this paper exhibited enhanced mechanical properties and mass transport capacity, making them ideal candidates for bone repair. A new design framework was provided for the development of high-performance bone scaffolds.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1503582/fullbone scaffoldtriply periodic minimal surfacemulti-functional poremechanical behaviormass transport capacity |
| spellingShingle | Rongwu Lai Rongwu Lai Jian Jiang Jian Jiang Yi Huo Hao Wang Sergei Bosiakov Yongtao Lyu Yongtao Lyu Lei Li Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores Frontiers in Bioengineering and Biotechnology bone scaffold triply periodic minimal surface multi-functional pore mechanical behavior mass transport capacity |
| title | Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores |
| title_full | Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores |
| title_fullStr | Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores |
| title_full_unstemmed | Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores |
| title_short | Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores |
| title_sort | design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi functional pores |
| topic | bone scaffold triply periodic minimal surface multi-functional pore mechanical behavior mass transport capacity |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1503582/full |
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