Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes
Objective: In frozen-thawed embryo transfer (FET) cycles, preparing a synchronous endometrium for the embryo is essential. Aim of this study is to provide individualized luteal support in hormonally replaced FET cycles, and to evaluate mid-luteal serum progesterone levels and pregnancy outcomes. S...
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Medical Network
2022-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1122 |
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| author | Gulsen Dogan Durdag Gizem Bektas Esengul Turkyilmaz Halime Goktepe Meltem Sonmezer Yavuz Emre Sukur Batuhan Ozmen Cem Atabekoglu Murat Sonmezer |
| author_facet | Gulsen Dogan Durdag Gizem Bektas Esengul Turkyilmaz Halime Goktepe Meltem Sonmezer Yavuz Emre Sukur Batuhan Ozmen Cem Atabekoglu Murat Sonmezer |
| author_sort | Gulsen Dogan Durdag |
| collection | DOAJ |
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Objective: In frozen-thawed embryo transfer (FET) cycles, preparing a synchronous endometrium for the embryo is essential. Aim of this study is to provide individualized luteal support in hormonally replaced FET cycles, and to evaluate mid-luteal serum progesterone levels and pregnancy outcomes.
Study Design: In this prospective cohort study, 30 patients were included in a university hospital in six month-period. Serum progesterone level on embryo transfer day was monitored, and if it was found to be below the lower limits defined by previous studies (10 ng/mL), additional 100 mg intramuscular micronized progesterone was administered once.Mid-luteal progesterone levels and pregnancy outcomes were recorded.
Results: There was no significant difference between mid-luteal progesterone levels of the patients whose transfer day progesterone was above and below 10 ng/mL (p=0.481). Although clinical pregnancy rate tended to be higher in patients whose mid-luteal progesterone was above 10 ng/mL, it was also not statistically significant.
Conclusion: This is the first study in which vaginal progesterone treatment was supported by intramuscular progesterone according to serum progesterone values for the purpose of individualized progesterone support. Significant difference was not found in pregnancy outcomes. However, further studies are required to optimize management and improve pregnancy rates in hormonally treated FET cycles.
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| format | Article |
| id | doaj-art-7a669eb10ebd4f1491e21a4f09760234 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-7a669eb10ebd4f1491e21a4f097602342025-02-11T21:14:46ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182022-03-0128110.21613/GORM.2020.1122Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy OutcomesGulsen Dogan Durdag0Gizem Bektas1Esengul Turkyilmaz2Halime Goktepe3Meltem Sonmezer4Yavuz Emre Sukur5Batuhan Ozmen6Cem Atabekoglu7Murat Sonmezer8Başkent UniversityAdana Application and Research CenterGürgan ClinicAnkara City HospitalKonya Training and Research HospitalPrivate officeAnkara University Faculty of MedicineAnkara University Faculty of MedicineAnkara University Faculty of MedicineAnkara University Faculty of Medicine Objective: In frozen-thawed embryo transfer (FET) cycles, preparing a synchronous endometrium for the embryo is essential. Aim of this study is to provide individualized luteal support in hormonally replaced FET cycles, and to evaluate mid-luteal serum progesterone levels and pregnancy outcomes. Study Design: In this prospective cohort study, 30 patients were included in a university hospital in six month-period. Serum progesterone level on embryo transfer day was monitored, and if it was found to be below the lower limits defined by previous studies (10 ng/mL), additional 100 mg intramuscular micronized progesterone was administered once.Mid-luteal progesterone levels and pregnancy outcomes were recorded. Results: There was no significant difference between mid-luteal progesterone levels of the patients whose transfer day progesterone was above and below 10 ng/mL (p=0.481). Although clinical pregnancy rate tended to be higher in patients whose mid-luteal progesterone was above 10 ng/mL, it was also not statistically significant. Conclusion: This is the first study in which vaginal progesterone treatment was supported by intramuscular progesterone according to serum progesterone values for the purpose of individualized progesterone support. Significant difference was not found in pregnancy outcomes. However, further studies are required to optimize management and improve pregnancy rates in hormonally treated FET cycles. https://gorm.com.tr/index.php/GORM/article/view/1122Frozen-thawed cyclesIn vitro fertilizationLuteal support Pregnancy rate Medroxyprogesterone acetate |
| spellingShingle | Gulsen Dogan Durdag Gizem Bektas Esengul Turkyilmaz Halime Goktepe Meltem Sonmezer Yavuz Emre Sukur Batuhan Ozmen Cem Atabekoglu Murat Sonmezer Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes Gynecology Obstetrics & Reproductive Medicine Frozen-thawed cycles In vitro fertilization Luteal support Pregnancy rate Medroxyprogesterone acetate |
| title | Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes |
| title_full | Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes |
| title_fullStr | Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes |
| title_full_unstemmed | Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes |
| title_short | Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes |
| title_sort | effect of individualized progesterone supplementation for luteal support in frozen thawed cycles on pregnancy outcomes |
| topic | Frozen-thawed cycles In vitro fertilization Luteal support Pregnancy rate Medroxyprogesterone acetate |
| url | https://gorm.com.tr/index.php/GORM/article/view/1122 |
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