Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels
OBJECTIVE: The purpose of this study is to investigate the influence of MTHFR gene polymorphisms which may effect the interaction in between homocysteine, folic acid and vitamin B12 metabolisms. STUDY DESIGN: The subject of this study is consisted of 165 patients who were obtained from “Hacettepe U...
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Medical Network
2013-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/171 |
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| author | Tuba Günebak Şahin Berkan Sayal Erdal Coşgun Tanju Besler Sinan Beksaç |
| author_facet | Tuba Günebak Şahin Berkan Sayal Erdal Coşgun Tanju Besler Sinan Beksaç |
| author_sort | Tuba Günebak Şahin |
| collection | DOAJ |
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OBJECTIVE: The purpose of this study is to investigate the influence of MTHFR gene polymorphisms which may effect the interaction in between homocysteine, folic acid and vitamin B12 metabolisms.
STUDY DESIGN: The subject of this study is consisted of 165 patients who were obtained from “Hacettepe University Maternal Fetal Medicine Data Base”. These were married women of childbearing age with MTHFR gene polymorphisms who experienced bad obstetrical history. Plasma total homocysteine, serum folic acid and vitamin B12 levels of the subjects were analysed and the interrelation between these nutritional factors was examined.
RESULTS: Both folic acid and vitamin B12 are significantly important and effective factors in homocysteine metabolism in MTHFR mutant subjects.
CONCLUSION: Folic acid is a much more important mass measure for controlling elevation of plasma homocysteine concentration.
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| format | Article |
| id | doaj-art-7bb0b379063345cca118ac7675d140c4 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2013-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-7bb0b379063345cca118ac7675d140c42025-02-11T21:20:11ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182013-04-01191110Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood LevelsTuba Günebak Şahin0Berkan Sayal1Erdal Coşgun2Tanju Besler3Sinan Beksaç4Hacettepe University Faculty of Health Sciences, Department of Nutrition and Dietetics, AnkaraHacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, AnkaraHacettepe University Faculty of Medicine, Department of Bioistatistics, AnkaraHacettepe University Faculty of Health Sciences, Department of Nutrition and Dietetics, AnkaraHacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara OBJECTIVE: The purpose of this study is to investigate the influence of MTHFR gene polymorphisms which may effect the interaction in between homocysteine, folic acid and vitamin B12 metabolisms. STUDY DESIGN: The subject of this study is consisted of 165 patients who were obtained from “Hacettepe University Maternal Fetal Medicine Data Base”. These were married women of childbearing age with MTHFR gene polymorphisms who experienced bad obstetrical history. Plasma total homocysteine, serum folic acid and vitamin B12 levels of the subjects were analysed and the interrelation between these nutritional factors was examined. RESULTS: Both folic acid and vitamin B12 are significantly important and effective factors in homocysteine metabolism in MTHFR mutant subjects. CONCLUSION: Folic acid is a much more important mass measure for controlling elevation of plasma homocysteine concentration. https://gorm.com.tr/index.php/GORM/article/view/171Methylenetetrahydrofolate reductaseHomocysteineFolic acidVitamin B12 |
| spellingShingle | Tuba Günebak Şahin Berkan Sayal Erdal Coşgun Tanju Besler Sinan Beksaç Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels Gynecology Obstetrics & Reproductive Medicine Methylenetetrahydrofolate reductase Homocysteine Folic acid Vitamin B12 |
| title | Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels |
| title_full | Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels |
| title_fullStr | Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels |
| title_full_unstemmed | Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels |
| title_short | Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels |
| title_sort | methylenetetrahydrofolate reductase enzyme mutations and relationship of homocysteine vitamin b12 and folate blood levels |
| topic | Methylenetetrahydrofolate reductase Homocysteine Folic acid Vitamin B12 |
| url | https://gorm.com.tr/index.php/GORM/article/view/171 |
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