More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens
Abstract Background Invasive infections by Nocardia farcinica, Aspergillus species (spp.) and Candida dubliniensis are rare infectious complications in patients diagnosed with multiple myeloma. Case presentation. In this case report, we describe a patient who received three lines of therapy, with pr...
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BMC
2025-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-024-10387-z |
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| author | Lotte Vrijders Erwin Ho Danielle Van der Beek Inge Vrelust Heleen Nailis |
| author_facet | Lotte Vrijders Erwin Ho Danielle Van der Beek Inge Vrelust Heleen Nailis |
| author_sort | Lotte Vrijders |
| collection | DOAJ |
| description | Abstract Background Invasive infections by Nocardia farcinica, Aspergillus species (spp.) and Candida dubliniensis are rare infectious complications in patients diagnosed with multiple myeloma. Case presentation. In this case report, we describe a patient who received three lines of therapy, with proteasome inhibitors, corticosteroids, cyclophosphamide and lenalidomide, and who was concurrently infected with these three opportunistic pathogens. A blood stream infection with C. dubliniensis was treated with 4 weeks of anidulafungin. Aspergillus spp. was treated for 12 weeks with voriconazole. N. farcinica treatment was continued indefinitely with co-trimoxazole and moxifloxacin after regression at discharge of brain abscesses and the pulmonary aspergilloma. Conclusion The diagnostic challenges and management in this particularly vulnerable patient are highlighted. |
| format | Article |
| id | doaj-art-7c4a7e0f2f4d4ce0b885733261dab03b |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-7c4a7e0f2f4d4ce0b885733261dab03b2025-02-09T12:14:53ZengBMCBMC Infectious Diseases1471-23342025-02-012511610.1186/s12879-024-10387-zMore than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimensLotte Vrijders0Erwin Ho1Danielle Van der Beek2Inge Vrelust3Heleen Nailis4Department of Haematology, AZ Turnhout HospitalDepartment of Medical Microbiology, AZ Turnhout HospitalDepartment of Medical Microbiology, AZ Turnhout HospitalDepartment of Haematology, AZ Turnhout HospitalDepartment of Medical Microbiology, AZ Turnhout HospitalAbstract Background Invasive infections by Nocardia farcinica, Aspergillus species (spp.) and Candida dubliniensis are rare infectious complications in patients diagnosed with multiple myeloma. Case presentation. In this case report, we describe a patient who received three lines of therapy, with proteasome inhibitors, corticosteroids, cyclophosphamide and lenalidomide, and who was concurrently infected with these three opportunistic pathogens. A blood stream infection with C. dubliniensis was treated with 4 weeks of anidulafungin. Aspergillus spp. was treated for 12 weeks with voriconazole. N. farcinica treatment was continued indefinitely with co-trimoxazole and moxifloxacin after regression at discharge of brain abscesses and the pulmonary aspergilloma. Conclusion The diagnostic challenges and management in this particularly vulnerable patient are highlighted.https://doi.org/10.1186/s12879-024-10387-zMultiple myelomaN. farcinicaBrain abscessCandida dubliniensisInvasive aspergillosis |
| spellingShingle | Lotte Vrijders Erwin Ho Danielle Van der Beek Inge Vrelust Heleen Nailis More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens BMC Infectious Diseases Multiple myeloma N. farcinica Brain abscess Candida dubliniensis Invasive aspergillosis |
| title | More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens |
| title_full | More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens |
| title_fullStr | More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens |
| title_full_unstemmed | More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens |
| title_short | More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens |
| title_sort | more than meets the eye nocardia farcinica candida dubliniensis and aspergillus spp co infection in a patient with multiple myeloma treated with multiple treatment regimens |
| topic | Multiple myeloma N. farcinica Brain abscess Candida dubliniensis Invasive aspergillosis |
| url | https://doi.org/10.1186/s12879-024-10387-z |
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