Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs
Summary: SARS-CoV-2, the virus responsible for COVID-19, is a highly contagious virus that can lead to hospitalization and death. COVID-19 is characterized by its involvement in the lungs, particularly the lower lobes. To improve patient outcomes and treatment options, a better understanding of how...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224029547 |
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| author | Jarrod Laro Biyun Xue Jian Zheng Monica Ness Stanley Perlman Laura-Isobel McCall |
| author_facet | Jarrod Laro Biyun Xue Jian Zheng Monica Ness Stanley Perlman Laura-Isobel McCall |
| author_sort | Jarrod Laro |
| collection | DOAJ |
| description | Summary: SARS-CoV-2, the virus responsible for COVID-19, is a highly contagious virus that can lead to hospitalization and death. COVID-19 is characterized by its involvement in the lungs, particularly the lower lobes. To improve patient outcomes and treatment options, a better understanding of how SARS-CoV-2 impacts the body, particularly the lower respiratory system, is required. In this study, we sought to understand the spatial impact of COVID-19 on the lungs of mice infected with mouse-adapted SARS2-N501YMA30. Overall, infection caused a decrease in fatty acids, amino acids, and most eicosanoids. When analyzed by segment, viral loads were highest in central lung tissue, while metabolic disturbance was highest in peripheral tissue. Infected peripheral lung tissue was characterized by lower levels of fatty acids and amino acids when compared to central lung tissue. This study highlights the spatial impacts of SARS-CoV-2 and helps explain why peripheral lung tissue is most damaged by COVID-19. |
| format | Article |
| id | doaj-art-7cd42863d19b4d89ab4ec4f41327ec5e |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-7cd42863d19b4d89ab4ec4f41327ec5e2025-02-07T04:48:01ZengElsevieriScience2589-00422025-02-01282111727Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungsJarrod Laro0Biyun Xue1Jian Zheng2Monica Ness3Stanley Perlman4Laura-Isobel McCall5Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USADepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USADepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USADepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USADepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USADepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA; Corresponding authorSummary: SARS-CoV-2, the virus responsible for COVID-19, is a highly contagious virus that can lead to hospitalization and death. COVID-19 is characterized by its involvement in the lungs, particularly the lower lobes. To improve patient outcomes and treatment options, a better understanding of how SARS-CoV-2 impacts the body, particularly the lower respiratory system, is required. In this study, we sought to understand the spatial impact of COVID-19 on the lungs of mice infected with mouse-adapted SARS2-N501YMA30. Overall, infection caused a decrease in fatty acids, amino acids, and most eicosanoids. When analyzed by segment, viral loads were highest in central lung tissue, while metabolic disturbance was highest in peripheral tissue. Infected peripheral lung tissue was characterized by lower levels of fatty acids and amino acids when compared to central lung tissue. This study highlights the spatial impacts of SARS-CoV-2 and helps explain why peripheral lung tissue is most damaged by COVID-19.http://www.sciencedirect.com/science/article/pii/S2589004224029547ImmunologyHuman metabolism |
| spellingShingle | Jarrod Laro Biyun Xue Jian Zheng Monica Ness Stanley Perlman Laura-Isobel McCall Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs iScience Immunology Human metabolism |
| title | Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs |
| title_full | Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs |
| title_fullStr | Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs |
| title_full_unstemmed | Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs |
| title_short | Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs |
| title_sort | severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs |
| topic | Immunology Human metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224029547 |
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