Targeted detection of endogenous LINE-1 proteins and ORF2p interactions

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions

Abstract Background Both the expression and activities of LINE-1 (L1) retrotransposons are known to occur in numerous cell-types and are implicated in pathobiological contexts such as aging-related inflammation, autoimmunity, and in cancers. L1s encode two proteins that are translated from bicistron...

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Main Authors: Mathias I. Nielsen, Justina C. Wolters, Omar G. Rosas Bringas, Hua Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Mobile DNA
Subjects:
Targeted proteomics
Mass spectrometry
SRM
PRM
LINE-1
Retrotransposon
Online Access:https://doi.org/10.1186/s13100-024-00339-4
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